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Absolute Structure Determination of Light Atom Compounds

D8 QUEST & D8 VENTURE – Pushing the limits – SC-XRD Application Note

Absolute Structure Determination of Light Atom Compounds

The absolute configuration is a crucial detail in the description of chiral compounds. Although the structural differences between such molecules and their mirror images may not be apparent to the inexperienced observer, the chirality can have very pronounced effects on the chemistry of the compounds.

Single crystal X-ray diffraction (SC-XRD, SCD) is the standard method for determining the absolute configuration of molecules since only a few experimentally challenging or indirect alternatives exist. The determination of the absolute configuration by X-ray diffraction makes use of small intensity differences between symmetry-equivalent reflections (Bijvoet pairs) caused by anomalous dispersion. The challenge is to measure these differences with the required accuracy. The D8 QUEST and D8 VENTURE are perfectly suited to provide this accuracy. The APEX3 software has all necessary tools for the data collection, processing and evaluation.