D8 VENTURE, TXS, KAPPA, single crystal X-ray diffraction

D8 VENTURE METALJET

GPCR Crystallography Moves In-House: Structure of the Human Orexin-1 StaR® to 2.77 Å - Application Note

D8 VENTURE METALJET

Here we present the first reported structure of a GPCR solved from diffraction data collected on a home-lab X-ray system. The structure of the human Orexin-1 StaR® (Stabilized Receptor) was solved at 2.77 Å resolution in a monoclinic space group using data collected on the D8 VENTURE METALJET in just over 2½ hours.

The unique combination of the Bruker METALJET and PHOTON II technologies, in concert with the Heptares StaR® technology, synergize to enable collection of diffraction data from GPCR crystals at a resolution high enough for Structure-Based Drug Design (SBDD).