Sungkyunkwan University Campus

Bruker Events

Bruker BioSpin would like to invite you to the 2019 Bruker APAC preclinical MRI user meeting. This one-day user meeting is held in conjunction with the Brain 2019 Satellite Meeting (https://www.cnirbrain2019.com/ ) and features keynote talks by top preclinical MRI scientists from around the globe, including Prof Seong-Gi Kim, Prof Afonso Silva and Dr. Luisa Ciobanu(see biographies and topics below). Attendees who wish to share their research and learn from the experts are warmly welcome to present their work to a large audience. Do not miss out on this exciting opportunity to expand your research network and advance your scientific knowledge.

When

July 11, 2019

Register

Click the link to register

Where

Seminar Room 86120, N Center, Sungkyunkwan University, Suwon, Korea

 

Directions:

https://cnir.ibs.re.kr/html/cnir_en/center/center_0103.html

 

 

 

Program

TimeTopicSpeaker
9:00Registration
9:30Opening Address and Products Update

Benjamin Chueh

Senior Sales Manager, Bruker BioSpin

10:00Chemical Exchange-sensitive MRI: Saturation Transfer and Spin Locking

Seong-Gi Kim

Director, IBS Center for Neuroscience Imaging Research

10:45Quantitative Imaging of Cerebral Micro-vasculatures In Rodents

HyungJoonCho,

PI, BISE, Ulsan National Institute of Science and Technology (UNIST)

11:15Break
11:30What’s New in Paravision

Way Cherng Chen

PCI Application Scientist, Bruker BioSpin

12:00Comprehensive MR Enhancement by Wideband MRI

Jyh-Horng Chen

Professor, Department of Electrical Engineering, National Taiwan University

12:30Lunch
1:30Center for Neuroscience Imaging Research Laboratory Tour
2:30Preclinical Functional MRI at Ultra-High Magnetic FieldsLuisa CiobanuHead, NeuroPhysicsTeam, NeuroSpinCEA-Saclay
3:15 Bioimaging in Drug Screening: In Vivo MRI for Brain Diseases

Taekwan Lee,

PI, Daegu GyeongbukMedical Innovation Foundation (DGMIF)

3:45Break
4:15Preclinical Neuroimaging of Brain Anatomy, Function and Disease

Afonso C. Silva,

Professor of Neurobiology, University of Pittsburg

5:00Awake Mouse fMRI During Association Learning

Tatsuhiro Hisatsune,

Professor, Graduate School of Frontier Sciences, University of Tokyo

5:30Programming in ParavisionYasvirTesiram, Senior Sales Manager, Bruker BioSpin
6:00Closing address

Kurt Schenker

Regional Sales Manager APAC, Bruker BioSpin

 

 

 

Keynote speakers

Dr. Luisa Ciobanu

Dr Luisa Ciobanu

Biography:

Dr. Luisa Ciobanu received her doctorate in Physics from The Ohio State University and has held research appointments at the University of Illinois at Urbana-Champaign and Pfizer, Inc. In 2007, she joined the staff of NeuroSpin at CEA-Saclay, where she now heads the NeuroPhysics team.

Topic:

Preclinical functional MRI at ultra-high magnetic fields

Despite the fact that BOLD-fMRI is routinely used to map brain activity and connectivity in preclinical and clinical settings, its exact relation with the underlying microscopic changes, either vascular or neuronal, is still not fully elucidated. The development of high magnetic fields promise substantial improvements in the contrast to noise ratio and the spatial resolution with which functional MRI maps are acquired possibly allowing the comparison with other, microscopic, techniques.

In the first part of the talk, Dr. Ciobanu will review the advantages, but also the challenges, imposed by imaging at ultra-high magnetic fields. Following this, Dr. Ciobanu will present recent results demonstrating that BOLD fMRI faithfully reports microvascular hyperemia, and that the detection of the smallest neuronal activation is limited only by its sensitivity.

Beside improved BOLD acquisitions, high magnetic fields allow the development of other alternative ways for studying neuronal activation. In the last part of her presentation, Dr. Ciobanu will describe a novel metabolic imaging approach, based on Chemical Exchange Saturation Transfer (CEST), for assessing the changes induced by neuronal stimulation in rat brains at 17.2T. Specifically, Dr. Ciobanu will present images acquired under glucose-sensitizing conditions showing a significant negative contrast that highlights the same brain regions as those activated in conventional BOLD maps.

 

 

Prof Afonso C. Silva

Prof Afonso C Silva

Biography:

Prof Afonso C. Silva received his Bachelor's Degree in Electrical Engineering from Universidade Federal de Pernambuco in Recife, Brazil, and his Ph.D. in Bioengineering from Carnegie Mellon University, where he worked on non-invasive MRI measurements of cerebral blood flow using the arterial spin labeling technique. He then went on to do post-doctoral training in the Center for Magnetic Resonance Research at the University of Minnesota, where he studied the temporal and spatial characteristics of functional brain hemodynamics under the supervision of Prof. Seong-Gi Kim. He joined NINDS as a Staff Scientist in 1999, and became an investigator in 2004. He moved to University of Pittsburg as Endowed Chair Full Professor of Neurobiology in 2018.

Topic:

Preclinical Neuroimaging of Brain Anatomy, Function and Disease

The common marmoset (Callithrix jacchus) is a small New World monkey that has gained significant recent interest in neuroscience research, due in great part for its compatibility with gene editing techniques, but also due to its tremendous versatility as an experimental animal model. As primates, marmosets retain the typical anatomical and functional organization of the human brain, offering new opportunities to systemically and comprehensively map the circuits and connectome of the primate brain. Neuroimaging modalities, including anatomical (MRI) and functional magnetic resonance imaging (fMRI), complemented by two-photon laser scanning microscopy and electrophysiology, have been at the forefront of unraveling the anatomical and functional organization of the marmoset brain, both in health and in experimental disease models. High-resolution anatomical MRI of the marmoset brain can be obtained with remarkable cytoarchitectonic detail and has a crucial role in elucidating the pathophysiological mechanisms of neurological disorders, such as multiple sclerosis and stroke. Functional MRI of the marmoset brain has been used to study various sensory systems, including somatosensory, auditory and visual pathways, while resting-state fMRI studies have unraveled functional brain networks that bear excellent correspondence to those previously described in humans. Two-photon laser scanning microscopy of the marmoset brain has enabled the simultaneous recording of neuronal activity from thousands of neurons with single cell spatial resolution. In this article, we aim to review the main results obtained by our group and our colleagues in applying neuroimaging techniques to study the marmoset brain in health and disease.

Prof Seong-Gi Kim

Prof. Seong Gi Kim

Biography:

Prof Seong-Gi Kim, Ph.D., is the Director of Neuroscience Imaging Research Center in the Institute of Basic Science (IBS), and professor of Biomedical Engineering in Sungkyunkwan Unviersity. He did his graduate works on in vivo NMR spectroscopy (1984-88) at Washington University, and postdoc training on structural biology at the University of Washington. In 1991, he moved to the Center for Magnetic Resonance Research in the University of Minnesota and was involved into the first human fMRI studies in 1992. He became full Professor before moving to the University of Pittsburgh in 2002. He was appointed inaugural Paul C. Lauterbur Chair in Imaging Research in 2009. Recently, he returned to Korea as the founding director of the Neuroscience Imaging Research Center. His major research focus is to develop magnetic resonance imaging techniques for measuring brain physiology and function, to determine relationships between neural activity and hemodynamic responses, and to apply imaging tools for answering neuroscience questions.

Topic:

Chemical Exchange-sensitive MRI: Saturation Transfer and Spin Locking

Many biomolecules have amide, amine, or hydroxyl protons that can exchange with water protons.  When the exchange rate is slower than the chemical shift difference between labile protons and water, its MR sensitivity can be dramatically enhanced by a chemical exchange-sensitive saturation transfer (CEST) or spin lock (CESL), which has been increasing used in many preclinical studies such as tumor, stroke, and muscle.  In this talk, Prof Kim will discuss principles, practical issues, recent technical developments, and in vivo applications.