maXis II LC-QTOF

maXis II™ / maXis II™ ETD

Unparalleled Versatility from Small Molecules up to Megadalton Complexes

Get your HR-QTOF with the latest HDC cell and 50 GBit/sec digitizer technology with a dedicated applications package for an amazing price. Click here to download the Flyer!

maXis II is THE market leading high-resolution LC-QTOF. This heralds a new era in QTOF technology with unprecedented performance across wide ranging applications to resolve the most demanding analytical challenges.

A full range of specified performance parameters is delivered simultaneously.

Bruker's Ultra-High Resolution QTOF (UHR) technology has reached new standards in accurate-mass LC-MSMS. In addition, the system offers Electron-Transfer Dissociation (ETD) capabilities for sequence analysis of intact proteins including monoclonal antibody subunits.

 

 

 

Furthermore, native state samples, including antibody drug conjugates, can be measured at these enhanced performance levels (Native Mass Spectrometry).

Let the maXis II achieve your goals in:


Please contact us for more information!

Technological Innovations

  • Record-breaking full sensitivity resolution (FSR) of > 80,000
  • Robust ETD capabilities with novel nCI source and Gas Enrichment Apparatus (optional)
  • Native Mass Spectrometry (optional) with enhanced desolvation of super molecular complexes
  • High Definition 5 orders of magnitude dynamic range achieved at UHPLC speeds due to 50 GBit/sec sampling technology-definitive trace analysis from complex, high-background matrices
  • Instant Expertise™ Intelligent self-optimizing MS/MS routines for expert-caliber results first time
  • One shot plug & play acquisition with triple-quadrupole sensitivity ensuring qualitative and quantitative results in one LC run with fastest time-to-success
  • DC gradient collision cell for high sensitivity, fast MS/MS

Applictions maxis II

Antibody Characterization - Intact and Subunit Analysis

Enhanced resolution and mass precision - for highly precise and accurate determinations of the monoisotopic masses of both the Light and Heavy Chains of mAb's on an LC timescale for automated confirmation of product identity and detection of impurities. Superb raw data quality allows for fast and easy detection of modifications (including deamidation) in biotherapeutic characterization without the need for time and cost intensive digestion and peptide mapping of the entire antibody.

 

 

 

 

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Complex Protein Mixture

The maXis II delivers superb dynamic range (5 orders of magnitude) at UPLC speeds enabling analysis of protein mixtures in complex, high-background matrices. For example > 1000 proteoforms resolved in a 35 min run from an undiluted serum sample.

 

  • • Sub-ppm mass accuracy & isotopic accuracy
  • • Isotopic resolution even for proteins > 40Kda
  • • MS/MS available for proteoform ID

 

Further information: Proteomics

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Native Mass Spectrometry (optional)

The High Mass Option combines adjustable Funnel 1 pressure with in-source CID on the maXis II to permit efficient desolvation and ionization of the native sprayed analyte without sacrificing other performance vectors. Thereby enabling easier application of native MS or high mass workflows for the structural investigation of larger proteins and/or protein complexes (including antibody drug conjugates).

 

Further Information: Intact Protein Characterization

Bruker App-Note: LCMS-94

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Robust LC-ETD capabilities

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with novel nCI source and Gas Enrichment Apparatus. Top-down MW measurement plus LC-ETD sequence data to detect and localize post-translational modifications (PTMs) in mAb's faster.

 

Further information: Top-Down Protein Characterization and Intact Protein Characterization

Bruker App-Note: ET-36

Bruker Daltonics services are performed by factory trained and certified engineers. DIN EN ISO 9001:2000 requirements are fulfilled.

 

Available services include:

  • Help desk service for a faster access to our support team, to your service order follow up and for general information
  • Planned maintenance, according to our requirement
  • Telephone support from highly-skilled troubleshooting professionals, to isolate and resolve hard- and software problems
  • Web-based remote instrument service for service diagnosis and applications support
  • Customer on-site repair and maintenance service
  • Spare parts availability typically over night or within a few working days worldwide
  • Compliance services for installation qualification, operational qualification / performance verification
  • Site planning and relocation
  • Advise to improve labs efficiency (consumable, method development & how to run the complete solution)

For Research Use Only. Not for Use in Clinical Diagnostic Procedures.