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Ultra high performance liquid chromatography (UHPLC) combined with true MSn and comprehensive drug libraries

Toxtyper 2.0: a complete solution for Clinical Research and Forensic Toxicology

The high demand in clinical research and forensic toxicology for comprehensive, specific, and transferable techniques has led to new developments in the field of Liquid Chromatography-tandem Mass Spectrometry (LC-MS). LC-MSn, combined with library searching, is one of the most promising screening solutions for modern toxicology research.

Libraries of Drugs

The Toxtyper 2.0 holds a high quality spectral library of more than 980 compounds of toxicology research interest with ˜ 3,000 spectra of MS, MS² and MS³ experiments and a smaller targeted library for Drugs of Abuse screening research. The library search module, as part of Brukers' new Toxtyper 2.0 software package, allows for unambiguous and fast (11-minute duty cycle) drug identification. In addition, the Toxtyper supports the Maurer/Wissenbach/Weber LC-MSn library* containing > 4500 drugs, metabolites, and artifacts.

Tailor-made sub-libraries for increased sensitivity

The Toxtyper provides the option to generate targeted libraries for specific needs.

Concentration of substances in whole blood
Example of selected drug detection in whole blood at a concentration of 0,5 ng/ml.

Sample preparation for a wide range of analytes

Different well-established sample preparation methods, such as liquid-liquid extraction (LLE), solid-phase extraction (SPE) or simple protein precipitation, can be used within the Toxtyper workflow and are well-suited for the extraction of a wide range of analytes such as hypnotics, neuroleptics, antidepressants, and many others.

Full Transferability by SmartFrag™

The Toxtyper 2.0 solution is setting new standards in LC-MS/MS toxicology research and transferability from lab-to-lab. Bruker's patented SmartFrag technology virtually removes variation and tuning from the MS/MS process. Furthermore, results and libraries are easily transferable from lab-to-lab and from experiment-to-experiment.

Amitriptyline MS2 results of 7 Toxtyper systems