Integrated Solution for Confident Chemical and Material Specificity, Quantity and Classification Screening. Now available with tools for Biologics analysis including PROFILE1 and HSQC Analysis and with Complete Reduction to Amplitude Frequency Table (CRAFT) for quantitative assessment from time-domain data

New Applications

Well-proven for the qNMR and quality control of small molecule APIs and raw materials, AssureNMR can now efficiently and accurately evaluate complex mixtures such as biologics, biofluids, and cell culture media. The Higher Order Structure (HOS) of Biologics are evaluated using a rapid similarity test, PROFILE1, or in more detail using HSQC analysis. Targeted fingerprinting enables identification and quantification of key metabolites of cell culture media to indicate when material is out of specification required for optimal production. I identification of components is enhanced by access to large, public databases. CRAFT aids in quantification by evaluating time domain data gaining freedom from traditional errors in processing.

Marco Guerrini from Ronzoni Institute, an expert in the analysis of the biologic heparin, said: “AssureNMR increases the analysis speed and is customizable. It allows the skilled NMR user to automate their workflow and make their sophisticated method of NMR acquisition and analysis accessible to any NMR lab, even one without an expert in the field of glycosaminoglycans.”

Anthony Ribeiro, Ph.D., of Duke University Medical Center said: “These features represent major enhancements to the AssureNMR software package for the detailed analysis of biofluid systems.” 

1 L. Poppe et al., Anal. Chem. 2013, 85, 9623−9629; L. Poppe st al., Anal.Chem. 2015, 87, 5539-5524.

A Track Record of Reliability

AssureNMR can be used to provide a detailed summary of sample composition and classification of a wide variety of samples, all in complete automation.

Featuring full integration for instrument control, AssureNMR uses Assure-System Suitability Test to verify and optimize the instrument performance. With capacity for use within GMP environments, AssureNMR provides a traceable record of sample analysis and results, ideal for R&D and production environments that need documentation of performance qualification tests.

Choose Your Solution

With new capabilities and product levels, you can choose the one that best fits your screening needs:

  • Launch: offers spectral database building tools with component identity search. Includes AssureSST and CMC-Assist
  • Ascent: enables of all of the above plus automated multi-component identity search, quantification and reporting. Fully customizable. Includes residual solvent SBASE 
  • Summit: enables of all of the above plus statistical analysis package, detection of outliers, an additional desktop software license and AMIX

Downloads

AssureNMR may be downloaded here

  • Mixture and Pure Material Analysis
  • Component Analysis

    • Component identification
    • Absolute and relative quantification
    • Equation builder tool

  • Spectral Database (SBASE)

    • SBASE generation tools
    • SBASE matching tools

  • Material Identity
  • Chemometric Analysis

    • Quantile Plot
    • SIMCA Outlier Detection
    • Multi-class classification
    • PLS Regression

  • Instrument Integration

    • Workflow management
    • Data quality check
    • System suitability tests for instrument optimization and verification

  • Automation

    • Data Acquisition
    • Quantitative and Qualitative Analysis
    • Report Generation

  • Fully Customizable
  • GxP Compatible

NMR System Requirements

  • TopSpin 3.5 for Windows 7
  • AVANCE II or newer console
  • NMR probe equipped with ATM and PT-100 or BTO-2000
  • BVT
  • BCU05
SampleXpress

Biologics

AssureNMR: Evaluating Cell Culture Media

AssureNMR™: CRAFT, Biologics, HMDB

Industrial Applications & Solutions

  • Aloe Vera quality control
  • Heparin sodium screening
  • Pharmaceutical material validation
  • Identify components within chemical aterials
  • Characterization of polymers and base oils
  • Identity and quality assurance of botanicals
  • Metabolic profiling analysis
  • Material characterization

For use when:

  • Similar analysis is needed on serveral samples
  • SOPs are utilized
  • Searching for specific materials
  • Quantification of components is needed
  • Calculations based on spectral integrations is needed
  • Quality control is required

ProfileNMR

Assure Aloe

Assure SBASE Development

Match Urine

Assure Heparin

SIMCA Outlier Detection

HSQC Analysis

PLS Quantification

LabScape

Service & Life Cycle Support for Magnetic Resonance and Preclinical Imaging

Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.

LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory

Download LabScape Brochure