MRI and PET combined...for the best of both worlds

The breakthrough in PET detector technology, together with the proven translational field strength MRI combined in one compact and easy to use instrument. Featuring PET Full Field of View Accuracy which provides homogeneous, constant PET resolution over the whole field of view and a newly developed 3T cryogen-free magnet . With a touch screen controlled motorized animal transport system, the PET/MR 3T simplifies your workflow and supports a broad spectrum of application fields, such as oncology, functional and anatomical neuroimaging, orthopaedics, cardiac imaging and stroke models.

Key Benefits

  • „„Unprecedented PET resolution up to 0.7mm, with Full Field Accuracy (FFA)*
  • Total body PET imaging with a leading PET sensitivity of 12%
  • „„Consistent quantification with attenuation correction based on high quality MRI data
  • Unique boost of MRI sensitivity and resolution with the MRI CryoProbe™ for mice and rats
  • Proven MRI performance with fully featured ParaVision® preclinical user interface, intrinsically supporting multimodal workflows
  • Accurate animal positioning with the motorized animal handling system including touchscreen operation enables automatic co-registration of images

* Homogeneous resolution better than 1.2 mm in the whole 80 mm FoV, with 10 times bigger area of optimum detection

Multimodal System Features

  • „„Accurate animal positioning with the motorized animal handling system including touchscreen operation enables automatic co-registration of images
  • Image fusion and quantitative analysis using PMOD
  • Whole body scans with a total field of view of >285 mm enabled by moving table acquisitions

PET Features

  • Sharp Total Body PET images with new PET Silicon PM detectors deliver consistent and reproducible quantification within the entire FOV, regardless of object size and position
  • Patented continuous LYSO crystals, unrestrained by discrete layers, and Silicon position sensitive photomultipliers with advanced depth-of-interaction (DOI)detection enable precise 3D localization of events. This eliminates the resolution degradation when moving out of the center of the PET Field-of-View (FOV)
  • No shielding required: PET technology is fully compatible with high magnetic field strength; spatial resolution and energy resolution are unchanged within the magnetic field
  • Exceptional count rate performance combined with 12% sensitivity for dynamic and gated studies for high temporal resolution and superior image quality

MRI Features

  • Superior MRI magnet technology ensures the magnet remains on field during power outage or cold water failure for up to 4 hours
  • Best in class homogeneity of ±0.1 ppm for a 50 mm DSV due to solid magnet design · MRI sequence portfolio of more than 1000 sequence variations, including wireless cardiac imaging using navigator based IntraGate methods with a choice of cartesianor radial readout, as well as short echo time imaging, such as UTE and ZTE
  • Widest range of RF-coils (~30) for mice and rats available, including coils for head, brain, cardiac, body, and multi-purpose applications
  • Over 100 validated and ready to use in vivo protocols and scan programs for mice and rats

PET/MR 3T simplifies your workflow and supports a broad spectrum of application fields, such as oncology, functional and anatomical neuroimaging, orthopedics, cardiac imaging and stroke models.

Glioma Tumor Development in Mice

PETInsert fig 5
Courtesy: Dr. Uwe Himmelreich, Dr. Matteo Riva, Dr. Willy Gsell, Dr. Cindy Casteels, Molecular Small Animal Imaging Center (MoSAIC), University hospital of Leuven, Belgium

•Early stage mouse glioma (5000 CT-2A cells, 8 days post injection) •Earliest detection of sub-mm³ tumors with superior high-field MRI resolution and soft tissue contrast •Tumor volume extracted from MRI: ~ 0.59 mm3 •Precise definition of the ROI based on high-field MRI allows PET tumor studies at the earliest stage

Tumor Heterogeneity Imaging in Mice

PETInsert fig 4
Courtesy: Sarah Belderbos, Dr. Uwe Himmelreich, Dr. Willy Gsell, Dr. Cindy Casteels, Molecular Small Animal Imaging Center (MoSAIC), University hospital of Leuven, Belgium

•Mouse Xenograft model: Human ovarian tumor cells (SKOV3) were injected subcutaneously in athymic nude mice •Images were taken four weeks after engraftment •T2W-RARE and FDG PET overlays •Both MRI and PET show tumor heterogeneity

Whole body Simultaneous PET/MRI in Mice

PET MRI Sequential Whole body mouse
Courtesy: Dr W Gsell and Prof U Himmelreich, KU Leuven, Belgium

•Large FOV in both modalities allows for simultaneous PET/MR whole body mouse imaging •T1 weighted MRI and PET uptake were dynamically imaged for 65 min Due to the large FOV of 148 mm the biodistribution of different organs can be studied simultaneously

Neurology in Rats

PET MRI Rat Brain CortecesPET MRI Whole Body Rat

18 FDG PET dynamic imaging with focus on neurology. Total body PET imaging: The large static PET FOV enables to simultaneously assess the tracer biodistribution in the whole body enabling kinetic analysis. Top image: the high PET resolution allows for this brain detail showing predominant tracer uptake in brain cortices. Bottom image: kidney function in excreting tracer's metabolites.

18FDG Cardiac Imaging in Rats

PET Rat Dynamic
Courtesy: B Kundu, M Chordia, J Li and S Berr, University of Virginia, US
PET Rat Dynamic TAC
Courtesy: B Kundu, M Chordia, J Li and S Berr, University of Virginia, US

•FDG Dynamic Cardiac Imaging: TAC (Time Activity Curves) •Blood (Inferior Vena Cava) shows peak concentration during injection, diminishing afterwards •Model Tissue (Myocardium) picks up activity progressively, plateauing after 1 hr •In Vivo Dynamic PET Imaging: Blood input function and kinetic parameters of the heart allow to quantify myocardial glucose and fatty-acid metabolism in addition to blood flow (using adequate tracers)

Total Body NaF PET Imaging in Mice

PET mouse NaF
Mouse NaF/PET, 60 minutes. Courtesy: Dr. W. Gsell, Prof. C. Deroose and Prof. U. Himmelreich, KU Leuven, Belgium

•Large FOV allows for Total Body PET imaging •The [F18]-NaF is used typical to detect bone metastasis although it can also be used imaging inflammation. High resolution across the entire FOV: The high resolution can be seen in the spine, rib cage, skull and hind paws.

LabScape

Service & Life Cycle Support for Magnetic Resonance and Preclinical Imaging

Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.

LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory

Download LabScape Brochure