NMR Applications in Drug Discovery

Introduction to NMR applications used in pharmaceutical industry for QC, screening and mixture analysis.


  • Theory of fragment binding to biomolecular targets
  • Ligand observed 1H and 19F NMR fragment screening experiments
  • HSQC chemical shift perturbation mapping
  • Data Analysis of NMR screening data
  • Quality control of small-molecule libraries by CMCa
  • Mixture analysis using ASSURENMR automation and robotics
  • High-throughput acquisition softwarePreparation of customized parameter sets
  • Sample Preparation for NMR screening


In lectures and practical sessions the concepts of 1D and 2D NMR experiments like waterLOGSY, Saturation Transfer Difference and relaxation based methods to probe for binding of small-molecules to biomolecular targets are elaborated. The participants will learn practical aspects of data analysis in small groups. Further topics are the use of CMCa and ASSURE for quality control of fragment libraries and mixture analysis. In most cases, the above applications are run in high-throughput with appropriate automation routines and robotics which will be introduced to the participants during hands-on sessions. Lectures about the theory of fragment binding to biomolecular targets in the context of the NMR time scale complete the program.

The broad scope of the training course makes it a perfect introduction for scientist from academia and industry with a background in chemistry, biology or biochemistry with interest in using NMR for the above applications.

Prerequisite Qualification:

Open to all AVANCE spectrometer users from academia and industry interested in the above topics

Overview: NMR Training Germany & Switzerland

Date and Place:

September 6-8, 2017 in Fällanden/Zürich

Registration form

Course Cost and Duration:

Course Cost1
Duration Language
(incl. documentation, coffee breaks and lunch)
3 days


Course Coordination:

Bruker BioSpin AG
Mrs. Svetlana Startseva
Industriestrasse 26
CH-8117 Fällanden
Phone: +41-44-825 95 42
Fax: +41-44-825 95 50
E-Mail: svetlana.startseva@bruker.com

 1Prices are subject to change without notice