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Dynamic Nuclear Polarization in the study of pharmaceuticals

Dynamic nuclear polarization (DNP) is a technique used to enhance signal intensity in nuclear magnetic resonance (NMR) studies. NMR tends to be an insensitive technique, especially when the compound of interest is not very concentrated in the sample. With DNP, a typical solid-state NMR sample is doped with unpaired paramagnetic electrons in the form of bi-radicals and the high polarization of the electron spin bath is transferred to nuclei, giving a large boost to the NMR signal. This improves sensitivity and enables the investigation of certain compounds that would otherwise not be possible, such as pharmaceutical preparations at natural isotopic abundance.

Seminar overview

In this webinar, DNP applications in the pharmaceutical industry and pharmaceutical science will be a particular focus, although any biologist, chemist, materials scientist or DNP NMR expert from other fields would also be interested in the discussion. In addition, a broad overview of DNP instrumentation will be given and various features of the NMR spectrometer will be described.

What you will discover

Talking at the seminar will be DNP expert Yongchao Su from Merck (Whitehouse Station, USA) and applications scientist Ivan Sergeyev from Bruker BioSpin (MA, USA).

DNP will be discussed as an enhancement technique in the study of natural abundance samples, which is particularly important in the pharmaceutical field. Ivan will discuss the great need to find techniques that will extend one-dimensional NMR to multi-dimensional NMR.

The use of DNP to study large proteins or complexes of proteins will also be touched on. The technique has boosted NMR signal to the point that it is possible to study anything from globular proteins to various membrane proteins so that specific structural questions can be quickly and easily answered. This is particularly the case in NMR crystallography, which is a hot topic. Yongchao is especially interested in conveying the benefits of DNP in terms of “really making something impossible, possible” and “changing the game board.”

A broad overview of Bruker’s solid-state dynamic nuclear polarization-enhanced NMR system will be given, including novel klystron-based DNP systems, utilizing a lower-power microwave source to generate electron polarization.  All of this will tie in with a description of the various academic and industrial applications that users of DNP NMR could employ. The research that will be discussed is in the phase of cutting-edge techniques and applications and should be of interest to anyone wanting to hear how DNP could revolutionize their workflow in years to come.

When

July 26, 2017
Session at 11:00am EDT (Boston Time)

Key topics

  • Pharmaceutical applications for the study of natural abundance samples in both industry and academia
  • NMR crystallography in pharmaceutical science for rapid 3-D structure determination
  • Advances in DNP NMR instrumentation
  • DNP applications in structural biology and materials science

View the recording or Download the slides

Who should attend

  • People in pharmaceutical sciences and pharmaceutical industry
  • DNP and solid-state NMR biologists, chemists and materials scientists
  • Anyone in the pharmaceutical field who is interested in rapid answers
  • Anyone interested in studying natural abundance materials
  • Anyone that uses solid-state NMR to answer any sort of structural or quality question in industry
  • Anyone generally interested in DNP

Presenters

Presenter 26 july 2017

Yongchao Su, Ph.D. (biography)
Pharmaceutical Sciences & Clinical Supply
Merck Research Laboratories

Ivan V. Sergeyev, Ph. D.(biography)
Applications Scientist – DNP
Bruker BioSpin Corporation, MA, USA

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