In this webinar, preclinical imaging specialist from Bruker, Todd Sasser, will introduce researchers Zbynek Novy and Milos Petrik from the Institute of Molecular and Translational Medicine at Palacky University. Novy and Petrik will describe the studies they have conducted into the use of rlabeled siderophores for the nuclear and optical imaging of both infection and cancer.
The researchers will discuss the use of rabiolabeled siderophores in the detection of Aspergillus fumigatus, a fungus that causes the life-threatening infection invasive aspergillosis (IA). Early and accurate detection of Aspergillus infection is crucial, but current methods lack sufficient specificity and/or sensitivity. Now, Novy, Petrik and co-workers have discovered that the Aspergillus siderophore triacetylfusarinine C shows great potential as sensitive and selective PET tracer of Aspergillus infection once it is labelled with the radionuclide Gallium-68 (68Ga).
The researchers will also describe how attaching two arginine-glycine-aspartic acid (RGD) and minigastrin peptides to the 68Ga-labelled siderophore fusarinine C, enables targeted in vivo imaging of tumors in animal models. RGD peptides have a high-affinity and selectivity for αvβ3 integrin, a cell-surface receptor that is overexpressed in activated endothelial cells and plays an important role in tumor angiogenesis, proliferation, invasiveness and metastatic potential. While a minigastrin analogue (MG11) enables targeting of cholecystokinin-2 (CCK-2) receptor overexpression being involved in rare diseases like gastrointestinal stromal tumors and medullary thyroid carcinoma.
The presenters will also refer to the preclinical imaging instruments they used, the Albira PET/ SPECT/CT and In-Vivo MS FX PRO systems from Bruker BioSpin. The Albira is a trimodal preclinical nuclear imaging system that uses completely unique continuous crystal technology that has been employed in a range of preclinical disease models including cancer, neurodegenerative and infection disease models. The Bruker In-Vivo Multispectral FX PRO system provides multimodal bioluminescence, fluorescence, radioisotopic and X-ray preclinical imaging.