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Mouse MRI for high-throughput phenotyping

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Webinar Overview

Preclinical MRI is a powerful translational tool that enables study of the brain in animal models using the same tools available clinically for humans. However, imaging in animal models also presents some unique challenges. Even simple study designs can quickly multiply to require hundreds or even thousands of images.

At the Mouse Imaging Centre, we have addressed this challenge using a form of parallel imaging called multiple-mouse MRI, in which multiple mice or tissue specimens are imaged simultaneously using multiple independent radiofrequency coils in the same magnet and gradient bore. While simple conceptually, this approach is enabling for many studies that would otherwise not be possible. Brian Nieman discusses multiple implementations, including current Bruker systems including a 7-Tesla magnet equipped with four cryogenically-cooled coils for in vivo imaging and a newly installed 24-channel 11.7-Tesla magnet equipped with 24 channels. 

On Demand Session

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Speaker

Dr. Brian Nieman

Senior Scientist at the Hospital for Sick Children, Toronto, Canada and Associate Professor at the University of Toronto, Toronto, Canada

Brian Nieman received his B.Sc. from the University of Waterloo (Dept. of Physics) in 2001. He started his working with MRI as part of his graduate studies under the mentorship of Dr. R. Mark Henkelman in the Dept. of Medical Biophysics at University of Toronto, completing his Ph.D. in 2006. He subsequently worked with Dr. Daniel H. Turnbull through a postdoctoral fellowship at the NYU School of Medicine (2006-2009). Brian returned to Toronto in 2009, starting as a Scientist at the Hospital for Sick Children and an Investigator at the Ontario Institute for Cancer Research. Brian is currently a Senior Scientist at the Hospital for Sick Children and an Associate Professor at the University of Toronto (Department of Medical Biophysics). In addition to development of imaging tools for mouse phenotyping, Brian’s research focuses on study of brain development after cancer treatment, including a mix of clinical and preclinical imaging.

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