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MRI of stroke - from molecules to circuits to outcome prediction

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Webinar Overview

MRI is a key modality to study animal models of stroke - from molecules to the whole brain. For example, fluorinated substances can be used for hypoxia mapping with fluorine-19 MRI while whole brain changes in structural networks can be mapped using the diffusion MRI connectome. However, there still is a translational gap between preclinical and clinical research. Preclinical researchers have mainly focused on brain tissue damage whereas improving functional outcome of the patient is the primary goal of clinicians.

Computational neuroscience applied to animal stroke models can help to close this gap by integrating MR neuroimaging and behavioral data. Philipp Boehm-Sturm’s group pooled 14 studies from their department to reach sample sizes that open the field for machine learning. With these tools at hand they asked important questions. Can they predict long term outcome after stroke in the mouse from an early MRI? Can they forecast the large differences in recovery? In his talk he addresses these questions as well as giving an insight into exciting community efforts on how we as preclinical MR researchers can collaborate better to enable more of such large scale studies.

On Demand Session

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Speaker

Dr. Philipp Boehm-Sturm

Leader of the “Experimental MRI” group and scientific head of the Charité Core Facility „7 T experimental MRIs“ of the Charité University Medicine of Berlin, Germany

Philipp Boehm-Sturm, PhD, is heading a group and the core facility “7T experimental MRIs” at the Charité University Medicine Berlin, in Germany. After completing a PhD in the physics department of the University of Cologne and the Max-Planck-Institute for Neurological Research in Cologne, he transferred to the Experimental Neurology Department and the Center for Stroke Research at the Charité in Berlin to offer his expertise in small animal MRI and quickly became the scientific lead of the imaging core facility. Dr. Boehm-Sturm won several prestigious prices, including poster prices at the ESMRMB, EMIM, and the Congress of Stem Cells and Tissue Formation, and is involved in the organization of MRI conferences such as the Fluorine MRI Symposium 2017 in Berlin. Key areas of his expertise include neuroimaging, connectome of the mouse brain, fluorine MRI as well as alternative contrast agent development for MRI.

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