See how ligand-induced conformational changes can sharpen compound prioritization
October 20, 2026
5:00 pm CEST | 11:00 am EDT | 8:00 am PDT
5:00 pm CEST | 11:00 am EDT | 8:00 am PDT
Webinar Overview
In this webinar, Prof. Ulrich Rant presents the scientific basis of Molecular Friction Sensing, the protein friction biosensor described in our featured preprint. The talk covers how the assay measures conformational change under near-physiological conditions and how that readout can support decisions in hit-to-lead and lead optimization.
What you'll learn
- How Molecular Friction Sensing detects ligand-induced conformational changes at sub-Ångström sensitivity
- Why a conformational readout adds information that affinity and kinetic data don't capture
- How to tell apart binders with similar affinities by their effect on protein structure
- Where the assay fits between routine binding assays and classical structural biology
- Results from the preprint, including the characterization of 22 confirmed carbonic anhydrase binders
Speaker
Prof. Dr. Ulrich Rant
Dresden University of Technology, Kurt Schwabe Institute for Sensor Technologies, Bruker Dynamic Biosensors, Dresden, Germany
Nur für die Forschung. Nicht für den Einsatz in klinischen diagnostischen Verfahren.