Fourier RxnLab and RxnLite

Discover RxnLab and RxnLite cutting-edge solutions for real-time reaction monitoring that bring the analytical power of benchtop NMR directly into your laboratory or production environment. 

Specifically designed to meet the needs of Process Analytical Technology (PAT) frameworks, these systems enable both in-line and on-line monitoring of chemical reactions, allowing for continuous, non-invasive data acquisition without disrupting the process. 

This approach provides time-resolved insights into key reaction parameters such as conversion rates, intermediate formation, and reaction kinetics, supporting a more comprehensive understanding and tighter control of chemical processes.

By leveraging benchtop NMR within PAT strategies, RxnLab and RxnLite offer several significant advantages. 

The technology delivers:

• Accurate, reproducible measurements without extensive calibration or reagents, lowering complexity and cost.
• High chemical specificity distinguishes similar compounds better than IR or Raman.
• Non-destructive analysis preserves sample integrity.
• Compact benchtop design fits easily into pilot plants or fume hoods.

With intuitive software interfaces, automated workflows, and seamless integration into existing control systems, RxnLab and RxnLite empower chemists and process engineers to make data-driven decisions in real time, enhance process robustness, accelerate scale-up and development, and ultimately ensure product quality and compliance. 

Whether you're in academic research, pharmaceutical development, or industrial chemical manufacturing, Bruker’s benchtop NMR solutions offer a transformative step forward in modern PAT-driven process optimization.

Free eBook: 'QbD & PAT for Dummies' offers a simple and easy to follow guide on what Quality by Design (QbD) and PAT are, the regulatory framework supporting these approaches, as well as how leveraging these concepts can positively transform production processes and quality testing.

InsightMR Flow Unit for Fourier 80

Designed for on-line and in-line reaction monitoring, InsightMR™ flow unit is a PAT-ready solution that enables comprehensive analysis and confident decision-making directly under actual operating conditions and captures the start of the reaction.

Fourier RxnLab

• Temperature controlled transfer lines: 25 to 60 °C capability
• Flow-through flow unit, based on industry tested well established InsightMR design
• Access to spectra deconvolution, predictions, chemometric and database tools
• Compatible with the use of the Fourier 80 PAL sample changer (max. sample capacity of 120)
• Tested to withstand pressures over 10 bar
• InsightMR 2.0 software and Mnova reaction monitoring plug-in
• Interchangeable glass tube. Proven robustness – industry tested
  

Fourier RxnLite

Same software capabilities, accessories and pressure limits as the Fourier RxnLab but without temperature control:

• Transfer lines at room temperature
• No adjustable temperature of the Fourier 80

InsightMR 2.0 Software

InsightMR software is a platform designed for the analysis of chemical processes by on-line NMR. Integrated acquisition control and data processing features enable on-the-fly acquisition parameter adjustment based on real-time kinetic data.

• Straightforward data acquisition with on-the-fly visualisation of build-up curves. Default experiments provided for both deuterated and non-deuterated solvents.
• Rapid and effortless handling of hundreds of stacked spectra.
• Supports acquisition, processing and analysis of series of 1Ds (different nuclei), interleaved experiments and multi samples in parallel.
• Automatic seamless transfer of spectra to Mnova reaction monitoring Workstation (e.g. phase, baseline and GSD).
• Access to database, prediction, assignment and chemometrics tools.
• Results are delivered as kinetic, and waterfall plots ready to report and/or export

• On-the-fly quantitative build-up curves without the need of tedious calibration steps. 
• Structural information for reagents, (bi)products and intermediates. 
• Reduced risk with direct knowledge transfer from high-field NMR (understanding) to low-field benchtop (control). 
• Increased selectivity, resolution and sensitivity compared to vibrational spectroscopy. 
• Used also to calibrate other techniques. 
• Straightforward installation and operation with minimal learning curve. 
• Affordable and with minimal cost of ownership. 
• Bringing NMR to the (bio)reactor.