Fourier RxnLab and RxnLite
Highlights
Benchtop NMR Technology for Reaction Monitoring
Discover RxnLab and RxnLite cutting-edge solutions for real-time reaction monitoring that bring the analytical power of benchtop NMR directly into your laboratory or production environment.
Specifically designed to meet the needs of Process Analytical Technology (PAT) frameworks, these systems enable both in-line and on-line monitoring of chemical reactions, allowing for continuous, non-invasive data acquisition without disrupting the process.
This approach provides time-resolved insights into key reaction parameters such as conversion rates, intermediate formation, and reaction kinetics, supporting a more comprehensive understanding and tighter control of chemical processes.
By leveraging benchtop NMR within PAT strategies, RxnLab and RxnLite offer several significant advantages.
The technology delivers:
- Accurate, reproducible measurements without extensive calibration or reagents, lowering complexity and cost.
- High chemical specificity distinguishes similar compounds better than IR or Raman.
- Non-destructive analysis preserves sample integrity.
- Compact benchtop design fits easily into pilot plants or fume hoods.
With intuitive software interfaces, automated workflows, and seamless integration into existing control systems, RxnLab and RxnLite empower chemists and process engineers to make data-driven decisions in real time, enhance process robustness, accelerate scale-up and development, and ultimately ensure product quality and compliance.
Whether you're in academic research, pharmaceutical and industrial development, Bruker’s benchtop NMR solutions offer a transformative step forward in modern PAT-driven process optimization.
Free eBook: 'QbD & PAT for Dummies' offers a simple and easy to follow guide on what Quality by Design (QbD) and PAT are, the regulatory framework supporting these approaches, as well as how leveraging these concepts can positively transform production processes and quality testing.
Features
InsightMR Flow Unit for Fourier 80
Designed for on-line and in-line reaction monitoring, InsightMR™ flow unit is a PAT-ready solution that enables comprehensive analysis and confident decision-making directly under actual operating conditions and captures the start of the reaction.
Fourier RxnLab
- Temperature controlled transfer lines: 25 to 60 °C capability
- Flow-through flow unit, based on industry tested well established InsightMR design
- Access to spectra deconvolution, predictions, chemometric and database tools
- Compatible with the use of the Fourier 80 PAL sample changer (max. sample capacity of 120)
- Tested to withstand pressures over 10 bar
- InsightMR 2.0 software and Mnova reaction monitoring plug-in
- Interchangeable glass tube. Proven robustness – industry tested
Fourier RxnLite
Same software capabilities, accessories and pressure limits as the Fourier RxnLab but without temperature control:
- Transfer lines at room temperature
- No adjustable temperature of the Fourier 80
InsightMR 2.0 Software
InsightMR software is a platform designed for the analysis of chemical processes by on-line NMR. Integrated acquisition control and data processing features enable on-the-fly acquisition parameter adjustment based on real-time kinetic data.
- Straightforward data acquisition with on-the-fly visualisation of build-up curves. Default experiments provided for both deuterated and non-deuterated solvents.
- Rapid and effortless handling of hundreds of stacked spectra.
- Supports acquisition, processing and analysis of series of 1Ds (different nuclei), interleaved experiments and multi samples in parallel.
- Automatic seamless transfer of spectra to Mnova reaction monitoring Workstation (e.g. phase, baseline and GSD).
- Access to database, prediction, assignment and chemometrics tools.
- Results are delivered as kinetic, and waterfall plots ready to report and/or export
Benefits
- On-the-fly quantitative build-up curves without the need of tedious calibration steps.
- Structural information for reagents, (bi)products and intermediates.
- Reduced risk with direct knowledge transfer from high-field NMR (understanding) to low-field benchtop (control).
- Increased selectivity, resolution and sensitivity compared to vibrational spectroscopy.
- Used also to calibrate other techniques.
- Straightforward installation and operation with minimal learning curve.
- Affordable and with minimal cost of ownership.
- Bringing NMR to the (bio)reactor.
Webinars
Testimonials
Dr. Andrei Bunescu, IPSOPHENE, Toulouse, France
As a powerful tool in Process Analytical Technology (PAT), NMR spectroscopy offers unmatched advantages for real-time process monitoring and control. One of its greatest strengths is that it provides easy-to-interpret data, making it accessible to both experts and non-experts. Additionally, NMR is a non-destructive method, allowing continuous analysis without altering the sample, which is crucial for maintaining process integrity.
Unlike many other analytical techniques, NMR is inherently quantitative and requires no complex calibrations, significantly reducing setup time and complexity. Its high dynamic range of concentration detection ensures precise measurements across various process conditions. Moreover, it is perfectly adapted for small molecule analysis and, importantly, for the analysis of complex mixtures rather than just pure compounds, making it ideal for real-world process applications.
The advent of Benchtop NMR has further expanded the applicability of NMR in PAT by offering a compact, cost-effective, and user-friendly alternative to traditional high-field instruments. These systems maintain the key advantages of NMR while requiring minimal infrastructure, enabling deployment directly on the production floor for on-site, real-time monitoring.
Beyond its analytical capabilities, NMR is an asset for process follow-up, providing real-time insights that enhance process understanding and optimization. Thanks to its robustness and reliability, it has become an indispensable technique for ensuring efficiency, quality, and consistency in modern manufacturing processes.
More Information
LabScape
Service & Life Cycle Support for Magnetic Resonance and Preclinical Imaging
Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.
LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory
