Scientific Publications Featuring PET/MR

Scientific publications featuring PET/MR technology, highlighting research applications, methods, and findings using PET/MR imaging.

Title	Authors	Link to Paper	Summary
Yttrium-86 is a positron emitting surrogate of gadolinium for noninvasive quantification of whole-body distribution of gadolinium-based contrast agents	Le Fur M, Rotile NJ, Correcher C, Clavijo Jordan V, Ross AW, Catana C, Caravan P	Open paper	This paper uses the PET isotope yttrium-86 as a surrogate for gadolinium to quantify the whole-body distribution of gadolinium-based MRI contrast agents.
Kidney glycolysis serves as a mammalian phosphate sensor that maintains phosphate homeostasis	Zhou W, Simic P, Zhou IY, Caravan P, Vela Parada X, Wen D, Washington OL, Shvedova M, Pierce KA, Clish CB, et al	Open paper	This study examines kidney glucose metabolism as a phosphate-sensing mechanism, using imaging-related metabolic assessment to investigate phosphate homeostasis.
Development of a fibrin-targeted theranostic for gastric cancer	Esfahani SA, et al	Open paper	This paper develops a fibrin-targeted theranostic for gastric cancer, combining molecular targeting with an imaging approach suitable for PET-based disease assessment.
Positron emission tomography-magnetic resonance imaging pharmacokinetics, in vivo biodistribution, and whole-body elimination of Mn-PyC3A	Zhou IY, Ramsay IA, Ay I, Pantazopoulos P, Rotile NJ, Wong A, Caravan P, Gale EM	Open paper	This PET/MRI study characterizes the pharmacokinetics, biodistribution, and whole-body elimination of the manganese-based contrast agent Mn-PyC3A.
Characterization of a preclinical PET insert in a 7 tesla MRI scanner: beyond NEMA testing	Gsell W, Molinos C, Correcher C, Belderbos S, Wouters J, Junge S, Heidenreich M, Vande Velde G, Rezaei A, Nuyts J, et al	Open paper	This technical study evaluates a preclinical PET insert operating inside a 7 T MRI scanner, extending performance assessment beyond standard NEMA testing.
In vitro and in vivo characterization of [⁶⁴Cu][Cu(elesclomol)] as a novel theranostic agent for hypoxic solid tumors	Liu T, Dahle M, Lystad MH, Marignol L, Karlsen M, Redalen KR	Open paper	This paper evaluates copper-64-labeled elesclomol as a PET theranostic agent for imaging and potentially treating hypoxic solid tumors.
CD38-specific gallium-68 labeled peptide radiotracer enables pharmacodynamic monitoring in multiple myeloma with PET	Sharma AK, Gupta K, Mishra A, Lofland G, Marsh I, Kumar D, Ghiaur G, Imus P, Rowe SP, Hobbs RF, et al	Open paper	This study uses a gallium-68-labeled CD38-specific PET tracer to monitor pharmacodynamic response in multiple myeloma.
A practical method for multimodal registration and assessment of whole-brain disease burden using PET, MRI, and optical imaging	Scarpelli ML, Healey DR, Mehta S, et al	Open paper	This paper presents a multimodal registration method that integrates PET, MRI, and optical imaging to assess whole-brain disease burden.
Collagen type I PET/MRI enables evaluation of treatment response in pancreatic cancer in pre-clinical and first-in-human translational studies	Esfahani SA, Ma H, Krishna S, Shuvaev S, Sabbagh M, Deffler C, Rotile N, Weigand-Whittier J, Zhou IY, Catana C, et al	Open paper	This translational study uses collagen type I PET/MRI to evaluate treatment response in pancreatic cancer across preclinical and first-in-human investigations.
Novel approach using [¹⁸F]FTHA-PET and de novo synthesized VLDL for assessment of FFA metabolism in a rat model of diet-induced NAFLD	Ustsinau U, Ehret V, Fürnsinn C, Scherer T, Helbich TH, Hacker M, Krššák M, Philippe C	Open paper	This study applies [¹⁸F]FTHA PET together with newly synthesized VLDL to assess free-fatty-acid metabolism in a rat model of diet-induced fatty liver disease.
Hyperpolarized [1^-13C]pyruvate magnetic resonance spectroscopic imaging for evaluation of early response to tyrosine kinase inhibition therapy in gastric cancer	Esfahani SA, Callahan C, Rotile NJ, Heidari P, Mahmood U, Caravan PD, Grant AK, Yen YF	Open paper	This paper uses hyperpolarized [1^-13C]pyruvate MR spectroscopic imaging to detect early metabolic response to tyrosine kinase inhibitor therapy in gastric cancer.
Simultaneous in vivo PET/MRI using fluorine-18 labeled Fe₃O₄@Al(OH)₃ nanoparticles: comparison of nanoparticle and nanoparticle-labeled stem cell distribution	Belderbos S, González-Gómez MA, Cleeren F, Wouters J, Piñeiro Y, Deroose CM, et al	Open paper	This simultaneous PET/MRI study compares the in vivo distribution of fluorine-18-labeled iron oxide nanoparticles with that of stem cells labeled using the same nanoparticles.
Simultaneous positron emission tomography and molecular magnetic resonance imaging of cardiopulmonary fibrosis in a mouse model of left ventricular dysfunction	Moon BF, Zhou IY, Ning Y, Chen YCI, Le Fur M, Shuvaev S, et al	Open paper	This study combines PET and molecular MRI to visualize cardiopulmonary fibrosis in a mouse model of left ventricular dysfunction.
Radiocaine: an imaging marker of neuropathic injury	Bartolo ND, Reid SE, Krishnan HS, Haseki A, Renganathan M, Largent-Milnes TM, Norwood BA, Loggia ML, Hooker JM	Open paper	This paper evaluates Radiocaine as a PET imaging marker for detecting neuropathic injury.
GMP-compliant fully automated radiosynthesis of [¹⁸F]FEPPA for PET/MRI imaging of regional brain TSPO expression	Chang CW, Chiu CH, Lin MH, Wu HM, Yu TH, Wang PY, Kuo YY, Huang YY, Shiue CY, Huang WS, Yeh SH	Open paper	This paper describes an automated GMP-compliant synthesis of [¹⁸F]FEPPA for PET/MRI measurement of regional TSPO expression in the brain.
HER3 PET imaging predicts response to pan receptor tyrosine kinase inhibition therapy in gastric cancer	Esfahani SA, de Aguiar Ferreira C, Rotile NJ, Ataeinia B, Krishna S, Catalano OA, Caravan P, Yen YF, Heidari P, Mahmood U	Open paper	This study uses HER3-targeted PET imaging to predict response to broad receptor tyrosine kinase inhibition in gastric cancer.
Automated GMP-compliant production of [¹⁸F]AlF-NOTA-octreotide	Tshibangu T, Cawthorne C, Serdons K, Pauwels E, Gsell W, Bormans G, Deroose CM, Cleeren F	Open paper	This paper describes automated GMP-compliant production of [¹⁸F]AlF-NOTA-octreotide, a radiotracer intended for somatostatin-receptor PET imaging.
Radiolabeling and PET-MRI microdosing of the experimental cancer therapeutic MN-anti-miR10b demonstrates delivery to metastatic lesions in a murine model of metastatic breast cancer	Le Fur M, Ross A, Pantazopoulos P, Rotile N, Zhou IY, Caravan P, Medarova Z, Yoo B	Open paper	This study uses PET/MRI microdosing to demonstrate delivery of the experimental MN-anti-miR10b cancer therapeutic to metastatic breast cancer lesions in mice.
Development and preclinical evaluation of [²¹¹At]PSAt-3-Ga: an inhibitor for targeted α-therapy of prostate cancer	El Fakiri M, Ayada N, Müller M, Hvass L, Gamzov TH, Clausen AS, et al	Open paper	This paper develops and preclinically evaluates the astatine-211 compound PSAt-3-Ga for targeted alpha therapy of prostate cancer, with radiolabeling supporting nuclear-medicine assessment.
Targeted dual-modality imaging of inflammation using ¹⁸F-radiolabeled iron oxide microparticles	Guillou A, Pedron S, Alhaddad N, Bonnard T, Martinez de Lizarrondo S, Gauberti M, Vivien D, Perrio C	Open paper	This paper develops an ¹⁸F-radiolabeled iron oxide microparticle platform for targeted dual-modality imaging of inflammation, combining PET sensitivity with magnetic particle contrast.
Novel [¹⁸F]fluorine-based PET tracers with polar but nonbasic linkers to image the fibroblast activation protein in the microenvironment of tumors	Köchel R, Schwegmann K, Breyholz HJ, Schäfers M, Wagner S, Wünsch B	Open paper	This study develops fluorine-18 PET tracers with polar, nonbasic linkers to image fibroblast activation protein in the tumor microenvironment.
Dynamic neuroimaging of intranasal-administered radiotracers to assess brain waste clearance	Smith K, Fan J, Gerdes J, Kessler R, Zinn K	Search for paper	This paper uses dynamic PET neuroimaging of intranasally administered radiotracers to assess waste clearance from the brain.
Multimodal imaging demonstrates antifibrotic effects of targeting α_vβ₆/α_vβ₁ integrins in biliary fibrosis	Zhou IY, Turner S, Boice A, Caravan P, Ning Y, Ay I, Rotile NJ, Schaub JR	Open paper	This multimodal imaging study assesses the antifibrotic effects of targeting alpha-v-beta-6 and alpha-v-beta-1 integrins in biliary fibrosis.
Automated synthesis and initial evaluation of [¹⁸F]FBAT for PET/MR imaging of inducible nitric oxide synthase	Yeh SHH, Huang WS, Chiu CH, Chen CL, Chen HT, Chi DY, et al	Open paper	This paper reports automated synthesis and initial evaluation of [¹⁸F]FBAT for PET/MR imaging of inducible nitric oxide synthase.
¹⁸F-FPP-RGD₂ PET imaging for interrogating target engagement and antifibrotic activity of an integrin antagonist in a mouse model of metabolic dysfunction-associated steatohepatitis	Zhou IY, Zhang C, Sojoodi M, Rotile NJ, Lan Y, Barrett SC, et al	Open paper	This study uses ¹⁸F-FPP-RGD₂ PET to measure integrin target engagement and antifibrotic activity in a mouse model of metabolic dysfunction-associated steatohepatitis.
High-throughput PET/MR imaging of rats and mice with transferable 3D-printed animal holders	Smith K, Zinn K	Search for paper	This paper presents transferable 3D-printed animal holders designed to increase throughput and consistency in PET/MR imaging of rats and mice.
Impaired brain glucose metabolism in glucagon-like peptide-1 receptor knockout mice	Li H, Fang Y, Wang D, Shi B, Thompson GJ	Open paper	This study investigates impaired brain glucose metabolism in GLP-1 receptor knockout mice, using metabolic imaging to characterize the neurological effect of receptor loss.
Performance evaluation of a PET of 7T Bruker Micro-PET/MR based on NEMA NU 4-2008 standards	Doss KKM, Mion PE, Kao YCJ, Kuo TT, Chen JC	Open paper	This technical paper evaluates the performance of a 7 T Bruker micro-PET/MR system according to NEMA NU 4-2008 standards.
Performance of PSMA-targeted radiotheranostics in an experimental model of renal cell carcinoma	Singh RR, Thotakura AK, Alati S, Lisok A, Jiang Z, Merino VF, Minn I, Yadav S, Markowski MC, Ged Y, et al	Open paper	This study assesses PSMA-targeted radiotheranostics in an experimental renal cell carcinoma model, using PET-compatible targeting to evaluate tumor uptake and therapeutic potential.
Development and characterisation of a thermoreversible sol-gel for intranasal delivery of MRI and PET imaging agents	Almahmoud A, Parekh HS, Paterson BM, Tupally KR, Cowin GJ, Nguyen A, Gulzar A, Vegh V	Open paper	This paper develops a thermoreversible intranasal sol-gel formulation for delivering both MRI and PET imaging agents.
Species-specific hepatic uptake of [⁶⁴Cu]Cu-EOB-NOTA: a newly designed hepatospecific PET agent	Fan J, Ramulu BJ, Mallett CL, Kenney LE, Kaufman N, Bhattacharyya T, et al	Open paper	This study characterizes the species-specific liver uptake of [⁶⁴Cu]Cu-EOB-NOTA as a newly designed hepatospecific PET agent.
Imaging tumor and ascites-associated macrophages in a mouse model of metastatic ovarian cancer	Foss CA, Wildes F, Mezzanzanica D, Podo F, Hung CF, Yadav S, Penet Vidaver MF	Open paper	This paper uses molecular imaging to visualize tumor-associated and ascites-associated macrophages in a mouse model of metastatic ovarian cancer.
PET/MRI and bioluminescent imaging identify hypoxia as a cause of programmed cell death ligand 1 image heterogeneity	Parkins KM, Krishnamachary B, Jacob D, Kakkad SM, Solaiyappan M, Mishra A, Mironchik Y, et al	Open paper	This multimodal study combines PET/MRI and bioluminescence imaging to identify hypoxia as a driver of heterogeneous PD-L1 imaging signals.
PET/MRI with ⁸⁹Zr-labelled antibodies provides insights into altered antibody pharmacokinetics in the chick embryo model	Benčurová K, Gündel D, Kieler M, Friske J, Kopka K, Helbich TH, Hacker M, Mitterhauser M, Philippe C, Balber T, Brandt MR	Open paper	This PET/MRI study uses zirconium-89-labeled antibodies to investigate altered antibody pharmacokinetics in the chick embryo model.
Quantifying glymphatic clearance with PET imaging of ¹⁸F-FDS in rats	Brown K, Smith K, Fan J, Zinn K	Search for paper	This study uses ¹⁸F-FDS PET to quantify glymphatic clearance in rats.
Quantitative accuracy of preclinical in ovo PET/MRI: influence of attenuation and quantification methods	Balber T, Benčurová K, Mayrhofer M, Friske J, Haas M, Kuntner C, et al	Open paper	This paper evaluates how attenuation correction and quantification methods affect the quantitative accuracy of preclinical in ovo PET/MRI.
Assessing PET performance, image quality, and attenuation correction in the presence of RF coils within a 9.4 T MRI for preclinical simultaneous imaging	Kuntner C, Friske J, Stessl A, Haas M, Breyer LL, Wanek T, et al	Open paper	This technical study examines PET performance, image quality, and attenuation correction when RF coils are present inside a 9.4 T MRI system used for simultaneous imaging.
Contrast-enhanced T1-weighted MRI, ¹¹C-DPA-713 PET and ¹¹C-CPPC PET as predictive imaging biomarkers of neuroinflammation in radiotherapy-induced brain injury	Maiti S, Yadav SK, Teitz M, Velarde E, Lee S, Lecksell K, et al	Open paper	This study compares contrast-enhanced T1-weighted MRI with ¹¹C-DPA-713 and ¹¹C-CPPC PET as predictive imaging biomarkers of neuroinflammation after radiation-induced brain injury.
Brown adipose tissue as a unique niche for islet organoid transplantation: insights from in vivo imaging	Sun A, Hayat H, Kenyon E, Quadri T, Amos D, Perkins K, et al	Open paper	This paper uses in vivo imaging to investigate brown adipose tissue as a transplantation site for islet organoids.
Evaluation of precalculated attenuation correction map for preclinical cardiac PET/MR using a ¹H/²³Na surface coil	Rida H, Guetlin M, Naveau M, Haas M, Lebrun A, Joubert M, Manrique A	Open paper	This technical study evaluates a precalculated attenuation correction map for preclinical cardiac PET/MR performed with a combined proton and sodium surface coil.
Combining DMI and [¹⁸F]FDG-PET can complement the assessment of metabolic dysfunction-associated fatty liver disease	Ehret V, Ustsinau U, Fürnsinn C, Scherer T, Starčuková J, Hacker M, Krššák M, Philippe C	Open paper	This study combines deuterium metabolic imaging with [¹⁸F]FDG PET to provide complementary assessment of metabolic dysfunction-associated fatty liver disease.
Imaging of fibroblast activation protein in the microenvironment of tumors by ¹⁸F-labeled positron emission tomography tracers with increased polarity	Köchel R, Wagner S, Breyholz HJ, Schäfers M, Schwegmann K, Wünsch B	Open paper	This paper develops more polar fluorine-18-labeled PET tracers for imaging fibroblast activation protein in the tumor microenvironment.