Scientist working with cell cultures

Obtaining subunits with FabRICATORTM Enzyme

  • Subunits can be readily obtained via cleavage of the antibody with FabRICATOR (Genovis)
FabRICATOR_cleavage_and_reduction.jpg
  • FabRICATOR cleaves the heavy chain of mAbs at the conserved Gly-Gly motif in the hinge region
  • Highly specific, simple 60 minute protocol  to produce Fc/2, Light Chain (LC) and Fd subunits