核磁共振波谱法测定新冠病毒RNA 成分的二级结构

This webinar took place on October 14th 2020

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总览

抗击新冠病毒引起的全球大流行病是当前社会和科学面临的最大挑战。德国法兰克福大学核磁共振研究小组发起倡议,于2020年3月底成立了一个由30个小组组成的国际联盟。利用核磁共振波谱,他们正在针对所有与新冠病毒相关的蛋白质进行结构检测,而其中的RNA成分则正在形成新型药物的潜在靶点。 

此外,他们将用RNA和蛋白质来筛选一个片段数据库,这个片段库是为了便于后续化学操作而设计的。(在本次研讨会中)我们专注于本项目的RNA部分,还将介绍项目的生化背景、核磁共振分配策略,并展示我们的筛选结果。 

Key Points

  • How to generate an NMR quantitative report on the basis of 150 metabolites
  • How to link this report to the metagene database
  • How clinical and general laboratory findings can be included and enhance the diagnostic power
  • How the method can be used to automatically get proposals for a patient’s disease
  • The value of a patient’s diagnosis repository for documentation and training

Who should attend?

  • Scientists and clinicians involved in the diagnosis and treatment of patients with inborn errors
  • Scientists and laboratory professionals interested in new NMR-based metabolomics applications

Speakers

Dr. Georg Frauendienst-Egger
Dr. Georg Frauendienst-Egger
Senior Consultant Neonatology Childrens Hospital Reutlingen
1971-86: Chemical engineer University Hannover and Berlin. “Projekt Phenylketonurie” with C. Jacobs and E. Mönch
1980-86: Medical studies FU Berlin
1986 -92: Residency in Paediatrics and Neonatology Univ. Würzburg, Set-up of a metabolic outpatient clinic and laboratory, Board certification in Paeditrics and Neonatology
1992- Klinikum Reutlingen: Senior Consultant Neonatology, Set-up of a metabolic outpatient clinic and laboratory
Dr. med. Friedrich Trefz
Dr. med. Friedrich Trefz
Senior Medical Consultant Bruker BioSpin
Prof. Dr. med. Friedrich Trefz received his medical degree from the University of Heidelberg in 1972. After receiving his degree, he had training in the biochemical laboratory at the Children’s Hospital in Heidelberg, and in 1975 he started his training in pediatrics under Prof.Dr. Horst Bickel. In 1983 he received his degree in Pediatrics, and in1985 he became the head of the “Sektion Pädiatrische Stoffwechselkrankeheiten”at the University Children’s Hospital of Heidelberg. Later in 2009, he received an additional degree in Pediatric Diabetes and Endocrinology. Prof. Dr. med. Trefz has received many grants from the German Federal Ministry of Education and Research, from 1994-2002 he was principal investigator of the International Maternal PKU study together with Prof. Richard Koch (Los Angeles), and Prof.Harvey Levy (Boston). He also was principal German investigator in the International Sapropterin Study from 2005 to 2007.In 1992 he moved from Heidelberg to Reutlingen and became the head of the department of pediatrics at the Klinik für Kinder und Jugendmedizin at Klinikum am Steinenberg, Reutlingen, School of Medicine, University of Tuebingen. In 2010 he retired from the Children’s Hospital in Reutlingen and became head of the outpatient medical Centre for Women, Children and Adolescents, Kreiskliniken Reutlingen, in Gammertingen, Germany. In 4/2015 he went back to the University Clinic of Heidelberg and established under the supervision of Prof. Dr. Georg Hoffmann and Prof. Dr. Peter Nawroth the adult outpatient clinic for rare metabolic disorders (up to12/2017).In 2018 he founded a private company for “Metabolic Consulting and Research” to further support knowledge and research in inborn errors of metabolism. He has more than 45 years of experience especially in treatment of patients with phenylketonuria.