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Life Science Research

Cell and Molecular Biology

Bruker’s innovative solutions enable scientists to understand dynamic processes in cell and molecular biology, supporting the development of novel applications that improve people’s lives.

New Insights into Structural Analysis and Dynamic Processes

Various life science applications now call for the analysis of vastly different types of biological samples and molecular processes. Demand for novel techniques enabling the accurate investigation of these samples and processes at very high temporal and spatial resolution has led to exciting innovation in both analytical instrumentation and processes.

Structural analysis and nanomechanical characterization of biological processes provides valuable insight into molecular and cell biology at the nanometer scale. Bruker’s state-of-the-art techniques enable scientists to investigate the morphology and surface structure of samples ranging from cells, cell membranes, and their cytoskeleton structures, down to individual biomolecules, nucleic acids, and proteins at submolecular resolution. 

Visualizing dynamic processes in real-time and characterizing dynamic mechanical properties in these ways provides an in-depth view of how complex biological systems function. 

As a result, scientists are better able to study cell mechanics underlying physiological conditions as well as signaling events, the role of proteins in cellular functioning, specific molecular interactions and binding events, and even cell-cell and cell-surface interactions. The ability to perform time-dependent and force-induced nanomanipulation on various biological samples – including single cells, DNA molecules, and membrane proteins – unearths a host of novel research possibilities.

High-resolution structural imaging and nanomechanical measurements provide valuable insights into the mechanisms of the cellular and molecular processes underlying both normal physiological and diseased states. This has profound implications for biological and biomedical research.

Choose Your Area of Interest

Biophysics and Biomechanics

Biophysics and biomechanical mechanisms play an important role in the regulation of cellular behavior, membrane dynamics and molecular biology, and have important implications for fields such as physiology, developmental biology, immunology and pathogenesis.

Cell and Environmental Mechanics

Mechanotransduction is the process in which cells actively detect and respond to physical cues and mechanical signals within their surrounding microenvironment. This leads to the activation of mechanosensitive signaling pathways within the cell which result in changes to the mechanical properties of the cell such as elasticity, adhesiveness, and viscosity.

Live-Cell Research

Live-cell imaging techniques have become an integral element of understanding cellular mechanisms and the visualization of subcellular structures. The complexity of highly dynamic biological processes is best observed in living cells in real time.

Nucleic Acid/Protein Imaging

Protein synthesis, from transcription, to translation, protein self-assembly and folding events, is a key process in all biological systems, and is critical for structural and functional regulatory mechanisms.

Receptor-Ligand Interactions

Receptor-ligand interactions are a major class of protein-protein interactions and play an important role in many biological processes such as metabolism, neurotransmission and cellular signal transduction pathways.

Single-Molecule Characterization

Observing molecular properties and conformational changes occurring at the single-molecule level leads to a more comprehensive understanding of complex biological processes and enable the characterization of the behavior of individual molecules inside living cells.