Improve your protein MS spectra quality while saving time
Progressing beyond the limits of HPLC
SampleStream™ and timsOmni™ bring sample preparation and mass spectrometry analysis together in an integrated analytical workflow. By exploring sample handling approaches beyond traditional HPLC or offline desalting, researchers can optimize data quality and expand the possibilities for MS-based protein characterization.
Ready for screening or deep characterization
Some projects require efficient comparison across a larger set of protein samples. Others benefit from spending more time investigating individual precursors in greater detail.
The combined SampleStream™ and timsOmni™ workflow is designed to support both high-throughput screening and in-depth top-down characterization.
Increase your analysis speed and quality
The joint workflow brings sample handling and measurement closer together. This can help research teams focus on meaningful differences across sample sets while reducing delays introduced by intermediate handling steps. It may also help minimize artefacts associated with storing samples in MS-friendly solvents prior to analysis.
Ready for deeper protein characterization
Not every research question can be answered with a rapid measurement. For samples that warrant closer investigation, the workflow supports extended top-down experiments on timsOmni™. This provides additional opportunity to explore proteoform complexity and gain a more detailed understanding of the protein under study. Resulting datasets can be processed with Bruker OmniScape, supporting workflows from de novo sequencing through proteoform confirmation.
Rather than committing every sample to the same analytical path, researchers can select the balance between throughput and analytical depth that best fits the scientific question.
A collaboration moving into research environments
Bruker and Integrated Protein Technologies are combining expertise in automated sample preparation, mass spectrometry, and top-down protein analysis to develop a connected SampleStream™ and timsOmni™ workflow.
Joint activities at IPT's Carlsbad, CA laboratory, Bruker Athens R&D, and with collaborators in Paris are extending the workflow into a variety of research environments. These collaborations provide opportunities to evaluate how automated point-of-use sample preparation can support real analytical challenges.
Together, we see significant opportunities to expand access to high-throughput intact-mass and top-down protein analysis. Integrating SampleStream™ with Bruker's timsOmni™ system represents a powerful combination for protein characterization workflows.
Dr. Philip Compton
CEO, Integrated Protein Technologies, Inc.
Could this approach fit your research?
The value of automated sample preparation depends on the samples you work with, the questions you want to answer, and the balance you need between throughput and analytical depth.
Start a conversation with our specialists about:
- Rapid intact-mass analysis
- Antibody and protein-conjugate screening
- Native mass spectrometry
- Automated buffer exchange
- Extended infusion for top-down analysis
- Online reduction or deglycosylation
- Workflow development for specific sample types
You can also request a tailored presentation for your team. Depending on your location and requirements, the session may be offered virtually or in person.
For Research Use Only. Not for Use in Clinical Diagnostic Procedures.