"Functional" PET/MRI and Protein Engineering of Hepatic OATP Transporter Activity
Webinar Overview
In his talk titled "Functional" PET/MRI and protein engineering of hepatic OATP transporter activity, Dr. Shapiro discusses the critical role of hepatic organic anion transporting polypeptides (OATPs) in mediating the cellular uptake of hepatospecific MRI contrast agents. He highlights two innovative ways to exploit OATP transporters to enhance biomedical imaging. First, he describes the application of simultaneous PET/MRI to assess hepatic function by pairing MRI contrast agents with complementary PET tracers, achieving a more comprehensive evaluation of liver function in vivo. Second, he introduces the use of OATPs as MRI reporter proteins, emphasizing recent protein engineering advancements aimed at enhancing the transport efficiency of OATPs and discussing novel imaging strategies to further optimize this approach.
On Demand Session