Flow NMR Probe

Large variety of high-resolution flow NMR probes - LC probes for chromatography and FI probes optimized for high sample throughput.

Bruker has developed a variety of high-resolution flow NMR probes:

  • LC probes with optimized flow cell size for chromatographic peaks and minimized band broadening during sample transfer.
  • FI probes optimized for high sample throughput.

Both types of flow probes have a built-in NMR flow cell, which delivers the following advantages:

  • The geometry of the RF coils, together with a fixed flow cell, provide higher NMR sensitivity in comparison to standard tube probes due to an improved filling factor.
  • Sample preparation like shimming is minimized or even not necessary, as only the sample solution itself is exchanged.
  • Preparation of samples in NMR tubes is no longer necessary, eliminating consumption of expensive NMR tubes.

The seamless link of the flow probe to a chromatography system or a liquid handler allows for direct transfer of the sample into the NMR probe. This direct transfer offers:

  • Minimized sample handling and thus minimized danger of contamination and decomposition of samples.
  • Highest speed and level of automation from sample preparation to NMR measurement.
  • The probe is the only modification necessary to convert a standard NMR spectrometer for flow applications and backwards. The probe change can be done in minutes.

Technical Details


  • A field strength of 300-900 MHz
  • Available flow cell sizes of 30, 60 and 120 µl
  • The NMR configuration is available as a SEI probe or TXI probe
  • By default with Z- gradients, and ATMA
  • Compatible with all HR-NMR spectrometers
  • Wetted Material Glass, stainless steel and PEEK™

Flow Injection (FI) Probes

  • With large ID capillaries for minimized backpressure and high flowrates
  • With internal heating of in- and outlet capillaries

Liquid Chromatography (LC) Probes

  • With low volume capillaries for minimized void volume and peak broadening