TIMS: A Powerful Tool for TPD Drug Discovery and Development

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Targeted protein degradation

Targeted protein degradation (TPD) is a promising new therapeutic approach that involves the selective degradation of disease-causing proteins. While TPD has shown great potential in preclinical studies, there is still much to learn about how to develop TPD drugs that are safe and effective in humans.

Trapped ion mobility spectrometry (TIMS) is a cutting-edge mass spectrometry technique that can be used to characterize the activity of TPD drugs on proteins of interest and the surrounding proteins in the cell. By quantifying proteins and related modifications, TIMS can help researchers to:

  • Confirm the mechanism of action of TPD drug candidates!
  • Make early predictions about possible side effects
  • Identify new TPD targets
  • Optimize TPD drug design and development


Explore the potential of TIMS applied to the discovery of novel TPD drugs and development. Discover the principles and applications of these techniques

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