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NMR* International COVID-19 Research Network at Work - Part 2

In the current worldwide COVID-19 pandemic situation, fast developments not only in vaccines are needed, but also in analytical techniques to detect the infection, predict outcomes during hospitalization and more and more important towards Long COVID.

Webinar Overview

In the current worldwide COVID-19 pandemic situation, fast developments are needed, not only in vaccines, but also in analytical techniques to detect the infection, predict outcomes during hospitalization, and more and more important towards Long COVID. Successful development of diagnostic routines needs a large number of samples and spectroscopic data generated thereof as well as comprehensive metadata coverage.

Initiated by Bruker and under the guidance of the Australian National Phenome Center (ANPC) run by Prof. Jeremy Nicholson, a worldwide international COVID Research Network consisting of several institutions collaborate, using completely standardized NMR procedures producing spectral data, exchangeable and enabling integration across the Network. In the webinar, prominent members of the Network will present the advantage of exchanging data and their results along with detection, outcome prediction, and Long-COVID risks and monitoring.

Nuclear Magnetic Resonance (NMR)* spectroscopy technology is a robust analysis technique that can provide a solution to the challenges of COVID-19 diagnosis and prediction based on metabolic changes caused by the virus once RUO results can be transferred into certified routines. The concept of phenoconversion and phenoreversion has been developed to follow these changes upon infection up to recovery. Applying NMR spectroscopy with its unique reproducibility and transferability enables the development of sensitive and specific routines for COVID analysis. This information is vital to develop diagnostic and predictive actions because NMR can connect metabolic information with systems biology on a personalized basis. Because of these advantages, NMR has the potential for the development of effective health monitoring, allowing early detection and treatment effects.

Additionally, the webinar speakers will discuss the level of complexity COVID-19 presents for emerging technology applications and scientific concepts. The mass scale of the pandemic encouraged international collaborative efforts to meet the challenges posed by the global outbreak of COVID-19. Initial research and development took old knowledge of treatments and techniques and attempted to adapt it in new ways to the current viral situation. This is where the need for powerful tools such as NMR presented itself most obviously.

Wednesday July 07, 2021

Time: 05:00PM Central European Summer Time

Key Topics

  • How experimental data suggest that NMR* metabolic profiles are suitable for COVID-19 patient stratification and post-treatment monitoring
  • How Standard Operating Procedures (SOP’s) guarantee the high spectral quality and reproducibility for the generation of identical spectra, independent of the lab, user, and system
  • How strong collaboration among research groups worldwide is ensured because of the strict standardization of the Bruker Avance IVDr platform*
  • How NMR* quantify hundreds of metabolites in a mixture in one single acquisition, without separation, turning biofluids into data.

Who Should Attend?

This webinar is of particular interested to heads of clinical research, heads of clinical chemistry, regulators and payors, University Hospitals and Medical Universities, Institute for Clinical and Experimental Medicine, Metabolic centers, Medical Doctors doing research in oncology, diabetes, infection, pediatrics, cardiology, epidemiologist.

* Bruker NMR Instruments are for research Use Only. Not for Use in Clinical Diagnostic Procedures.

Speaker

Ulrich Günther

University of Lübeck, Professor of Metabolomics - Institute for Chemistry and Metabolomics

The scientific focus of his research group is focussed on metabolomics and metabolism, mainly using NMR methods. He built the HWB-NMR facility at the University of Birmingham as a leading UK and European NMR centre, with involvements in many European infrastructure and research projects.

His engagement in metabolomics research includes real-time metabolism, tracer-based methods in particular to study metabolism in cancer cells, metabolomics in a medical context (with recent work on the effect of COVID-19 on the blood metabolome) and metabolomics in a nutritional context.

He enjoys working in a European and international context and has coined projects such as WordWide-NMR (WW-NMR) which included NMR centres from across the world, including China, India, and countries in South America, together with several European sites, to exchange staff members and to run joint international workshops around the world. He has been coordinator of several EU MarieCurie ITN networks, all focussed on NMR-methods and tracer-based metabolism (FP7 Metaflux, H2020 EUROPOL and HaemMetabolome). In 2018 he won a grant from EPSRC which will fund a 1GHz spectrometer for the HWB-NMR facility as part of a £20Million funding initiative which supports high-field NMR across the UK. He has also been part of several EU infrastructure (EU-NMR and Bio-NMR) and an eInfrastructure (PheNomeNal). He has published around 100 publications (https://www.researchgate.net/profile/Ulrich_Guenther, RG score 38, h-index 29). Since Oct 2019 he is Professor of Metabolomics at the University of Lübeck.

Christoph Trautwein

Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University Hospital, Eberhard Karls University Tübingen, Group Leader Metabolomics & Systems Medicine

Dr. Christoph Trautwein raised up in Southern Germany nearby Stuttgart where he first studied Environmental Engineering prior moving 2007 to Freiburg for his PhD and a second career in Molecular Medicine. After a Postdoc 2015-2016 at the Karlsruhe Institute of Technology he joined the Werner Siemens Imaging Center in the year 2017 where he now is leading the research group for Metabolomics & Systems Medicine.