The development of new PET tracers that target specific brain receptors has increased the popularity of receptor occupancy studies for drug development and for the study of neurological and neurodegenerative diseases.
Critical questions, such as whether the drug has crossed the blood brain barrier, engaged with its target receptor, and whether the dose administered achieves sufficient receptor binding for a desired therapeutic effect, can be answered by applying fully quantitative data analysis approaches, such as kinetic modelling. Furthermore, by combining PET and MRI, additional anatomical and functional information can be obtained, beyond what is possible with PET/CT.
During this webinar, PET experts Dr. Michael Placzek, and Dr. Joseph Mandeville will provide attendees with an outline of their current projects, describing the core principles of preclinical neuroimaging and discussing the benefits, challenges and exciting potential applications of receptor occupancy studies using simultaneous PET/MR.
To round off the webinar, Geoff Warnock from PMOD will present PMOD's tools for streamlined PET image processing, analysis and automated methods that you can use to accelerate your research.
This webinar will be of interest to researchers, postgraduate students, and principal investigators working in academia. Additionally, this webinar will be of interest to researchers working in the pharmaceutical sector, particularly in drug development. Researchers working with GPCRs – especially those working in small animal or drug discovery research – will also be interested in PET imaging's potential to complement their existing research programs.
Dr. Michael Placzek, PhD
Assistant Professor in Radiology
Harvard Medical School and Martinos Center for Biomedical Imaging
Joseph B. Mandeville, PhD
Martinos Center for Biomedical Imaging
Senior Application Scientist, PMOD