Recent instrumental breakthroughs in mass spectrometry and sample preparation methods are a real game-changer and have opened new possibilities for proteomic analysis implying extreme sensitivity at high throughput. Single-cell proteomics (SCP) analysis has become feasible. We optimized a timsTOF Ultra 2 instrument to maximize output results. Our robust and sensitive SCP workflow has been applied to diverse biological projects, including B lymphocytes subtyping and drugs effect on cancer.
Christine Carapito, Ph.D., CNRS Research Director, Co-head of the BioOrganic Mass Spectrometry Laboratory, CNRS and University of Strasbourg, Strasbourg, France
Charline Keller, Ph.D. Student, CNRS, University of Strasbourg, Strasbourg, France
Pauline Perdu-Alloy, Ph.D. Student, BioOrganic Mass Spectrometry Laboratory, CNRS and University of Strasbourg, Strasbourg, France
For Research Use Only. Not for use in clinical diagnostic procedures.