Cancer is a major cause of death worldwide and, given the aging global population, the number of deaths due to cancer is expected to continue to increase. The relationships between cancer, immune cells, and the collagen matrix are complex, and analyzing them requires the implementation of new technologies and ideas. Understanding the mechanisms behind these relationships will enable the development of more precise therapeutics and faster diagnostic tools.
The application of MEM with label-free fluorescence lifetime imaging microscopy and second-harmonic generation microscopy helps to move cancer research forward by providing highly precise data about these relationships.
Over the past two decades, multiphoton excitation microscopy (MEM) has enabled detailed intravital imaging of metastasis in animal models of cancer with supreme optical sectioning and minimal phototoxicity. In addition, MEM offers the possibility of fast imaging of unstained tissue based on its morpho-chemistry. As a result, MEM imaging has already greatly improved our ability to diagnose and treat cancer and will continue to play a significant role in preventing cancer-related deaths going forward.
Cancer researchers have successfully used Bruker multiphoton imaging systems to study the structure and physiological state of cells and tissues in normal and pathological conditions.