minispec mq series

Toothpaste Analyzer

Toothpaste and mouthwash contain many ingredients to enhance the quality and health benefits. Fluorine is added in typical amounts of 1000 to 1500 ppm to prevent cavities by strengthening tooth enamel.

With Time Domain Nuclear Magnetic Resonance (TD-NMR), the fluorine content can be accurately measured irrespective of the fluorine compound and the toothpaste matrix.


  • Most cost-effective at-line fluorine content determination
  • Measurement time < 10 min
  • Widely applicable for different toothpaste formulations
  • Automation option

Advantages compared to classical methods are the speed and accuracy of analysis. Sample preparation consists of filling glass tubes with paste and tempering them for 15 to 30 minutes. The subsequent measurement takes less than 10 minutes and can be carried out by untrained personnel. No chemical solvents are required, making this method the fastest, most convenient way of accurately determining the fluoride content in toothpaste.

The NMR method is independent of sample color, surface, etc., and does not destroy the paste. The analysis can be repeated as often as desired using the same sample.

The simplicity and the speed of the analysis make TD-NMR the method of choice for production, product development and quality control.

The TD-NMR analysis is based on the quantitative and linear signal response from the fluorine nuclei in the sample. Therefore the amplitude of the NMR signal S (Hahn-Echo) is directly proportional to the soluble fluorine mass.


Recommended Equipment

  • mq20 Toothpaste Analyzer
  • m+ software (21 CFR part 11 compliant)
  • IQ / OQ Documentation
  • 26 mm sample tubes
  • Precision Balance
  • Option: Automatic sample changer


Service & Life Cycle Support for Magnetic Resonance and Preclinical Imaging

Bruker’s commitment to provide customers with unparalleled help throughout the buying cycle, from initial inquiry to evaluation, installation, and the lifetime of the instrument is now characterized by the LabScape service concept.

LabScape Maintenance Agreements, On-Site On-Demand and Enhance Your Lab are designed to offer a new approach to maintenance and service for the modern laboratory