The application note introduces a set of solid-state heteronuclear correlation (HETCOR) experiments designed to correlate ¹H chemical shifts (CS) with nearby spin-½ heteronuclei, such as 19F, ¹³C, and 15N. These experiments enable researchers to obtain well-resolved ¹H CS information while simultaneously providing heteronuclear connectivity information. HETCOR experiments are crucial for detailed structural analysis of organic solids. The described techniques address the challenge of strong ¹H-¹H dipolar couplings that typically broaden resonance lines in proton-dense systems, thereby improving spectral resolution and enabling analysis. The solution is significant for users seeking to enhance their understanding of molecular packing, hydrogen bonding, and local conformations in complex materials.
Key points
- High-resolution ¹H–X correlation in proton-dense solids using homonuclear decoupling (FSLG) pulse sequences.
- Supports flexible setup for various nuclei (¹³C, ¹⁵N, ¹⁹F) and automated operation with IconNMR.
- Provides robust referencing and calibration procedures for accurate chemical shift assignment.
Download the detailed application note for step-by-step experimental guidance and calibration tips. These methods provide access to well-resolved ¹H dimensions while simultaneously yielding heteronuclear connectivity information.