A technology that simultaneously records membrane potential from multiple neurons in behaving animals will have a transformative effect on neuroscience research (1,2). Genetically encoded voltage indicators are a promising tool for these purposes; however, these have so far been limited to single-cell recordings with a marginal signal-to-noise ratio in vivo.
Bruker is actively developing solution for our customers pursuing this application. Please contact Bruker for more details or for opportunity to collaborate on this fascinating project.
1. Bando Y, Grimm C, Cornejo VH, Yuste R. Genetic voltage indicators. BMC Biol. 2019 Sep 12;17(1):71. doi: 10.1186/s12915-019-0682-0
2. Adam Y, Kim JJ, Lou S, Zhao Y, Xie ME, Brinks D, Wu H, Mostajo-Radji MA, Kheifets S, Parot V, Chettih S, Williams KJ, Gmeiner B, Farhi SL, Madisen L, Buchanan EK, Kinsella I, Zhou D, Paninski L, Harvey CD, Zeng H, Arlotta P, Campbell RE, Cohen AE. Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics. Nature. 2019 May;569(7756):413-417. doi: 10.1038/s41586-019-1166-7.