Hyperpolarized 129Xe MRI of Pulmonary Gas-Exchange in Rodents
In this webinar, Dr. Rohan Virgincar, MRI Applications Scientist at Bruker BioSpin, will give insight into the fundamentals and practical considerations for high-resolution hyperpolarized 129Xe MRI in rodents, based on his 7 years of research in this field at Duke University, USA. He will discuss important factors such as hyperpolarization, xenon gas-delivery using a hyperpolarized-gas-compatible ventilator, imaging considerations for ventilation and dissolved-phase imaging using the 3D ultrashort echo time method, image analysis techniques, and present examples of applications in clinically relevant rodent models of lung disease.
Key learning objectives
- RF coils and calibrations
- Key parameters for ventilation and dissolved phase imaging using UTE3D
- 129Xe spectroscopy
- Applications in lung disease models
- Animal set up, anesthesia, and physiological monitoring
- Xenon polarization, and delivery using a custom hyperpolarized-gas compatible ventilator
Who should attend?
Researchers focused on pulmonary diseases and pulmonary imaging techniques, MRI scientists working with X-nuclei, and those interested in hyperpolarization techniques.