TopSolids – Your Key to Unlock Solid-State NMR

In recent years, solid-state NMR has consolidated its role as a powerful analytical tool to provide answers where common methods like solution NMR or X-ray crystallography fail. However, the rather difficult setup of hardware and experiments still limits the adoption of solid-state NMR, labelling it as a method for experts. With TopSolids™ Bruker overcomes this necessity for extensive prior knowledge to use one of the most important techniques for understanding insoluble protein systems and solid samples, e.g. from catalysis, batteries, pharmaceutical or material sciences.

TopSolids™ is a software package especially designed to give easy access into the delicate solid-state NMR setup of hardware and experiments. The webinar will put a strong focus on the probe setup, where the system is adjusted for best performance. Though routine work for an expert this step can be time-consuming and especially complicated and daunting for a solid-state NMR novice. The webinar will showcase how TopSolids combines automated spectrometer adjustments with pre-defined protocols in shortest time.

Furthermore, the webinar will demonstrate different features for protein and non-protein samples focusing again on automated procedures supporting the successful setup of experiments. Overall, the handling of projects and parameters will be highlighted, including parameter import-export options, automated parameter calculations and safety checks.

View the recording or download the slides

Key Topics

Intelligent handling of projects & parameters, incl. importing and exporting (PDF)
Automated probe setup: assisted magic-angle adjustment, pulse determination, shimming, spectral referencing, quality evaluation of adjustments
Experiments for protein samples: backbone and distance measurements up to 4Ds, automated processing (≤3D)
Experiments for non-protein samples: any X nucleus, incl. quadrupolar nuclei, ≤2D experiments ( X, HX CP, HetCor, MQMAS), automated processing

What to Expect

The webinar will showcase the ease of use of solid-state NMR when using TopSolids on various examples to highlight how anybody, solid-state NMR expert as well as novice, can set up the hardware and run experiments in a fast and convenient way leading to high quality results with a minimized risk of damage or operating errors.

Who Should Attend?

The webinar is aimed for solid-state NMR experts and novices:

Solid-state NMR novices
Non-NMR users with an interest in solid-state NMR
Solution NMR spectroscopists who consider doing solid-state NMR
Graduate students who are doing or intend to do solid-state NMR
Solid-state NMR spectroscopists

Speakers

Dr. Venita Decker

Product Manager FT-NMR benchtop solutions, BBIO, Bruker BioSpin, Rheinstetten, Germany

Dr. Venita Decker studied Neuroscience, but did her dissertation in the field of solid-state NMR (Max Planck Institute for Biophysical Chemistry, Goettingen). In 2012, she joined the Bruker solid-state NMR application. As a NMR-late entrant she since then actively supported Bruker solutions that simplify the complexity of NMR (TopSolids, the minispec FormCheck). Since 2018, she is the Product Manager for FT-NMR benchtop solutions, bringing her mission to the next level.

Dr. Sebastian Wegner

Product Manager Solid-State NMR, Bruker Biospin - Germany

studied physics at the University of Münster and did his PhD in physical chemistry using solid-state NMR to characterize amorphous glass systems in melt and at room temperature. At Bruker he is the Product Manager for solid-state NMR.