Journal Club

Current Status of Potential Therapeutic Candidates for the COVID-19 Crisis
Jiancheng Zhang, Bing Xie and Henji Hashimoto, Brain Behav Immun 2020

Thoughts on What Chemists Can Contribute to Fighting SARS‐CoV‐2 – A Short Note on Hand Sanitizers, Drug Candidates and OutreachTill Opatz, Joerg Senn-Bilfinger and Clemens Richert, Angew Chem Int Ed 2020, 59: 2–7

Developing Therapeutic Monoclonal Antibodies at Pandemic Pace
Brian Kelley, Nat Biotechnol 2020, 38: 540–545

The Race for Coronavirus Vaccines: a Graphical Guide
Ewen Callaway, Nature 2020, 580: 576-577

The COVID-19 Vaccine Development Landscape
Tung Thanh Le, Zacharias Andreadakis, Arun Kumar, Raúl Gómez Román, Stig Tollefsen, Melanie Saville & Stephen Mayhew, Nat Rev Drug Discov 2020, 19: 305-306

Signal Amplification by Reversible Exchange for COVID-19 Antiviral Drug Candidates
HyeJin Jeong et al., ChemRxiv. 2020
Preprint revised on April 06, 2020

Nuclear Magnetic Resonance Structure Shows that the Severe Acute Respiratory Syndrome Coronavirus-Unique Domain Contains a Macrodomain Fold
Amarnath Chatterjee, Margaret A. Johnson, Pedro Serrano, Bill Pedrini, Jeremiah S. Joseph, Benjamin W. Neuman, Kumar Saikatendu, Michael J. Buchmeier, Peter Kuhn & Kurt Wüthrich, Journal of Virology 2009, 83: 1823-1836

 
NMR Structure and Localization of a Large Fragment of the SARS-CoV Fusion Protein: Implications in Viral Cell Fusion
Mukesh Mahajan et. al., Biochim Biophys Acta Biomembr 2018, 1860: 407-415

 
Synthesis of Remdesivir Including Characterisation by NMR

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
Dustin Siegel, et. al., J Med Chem 2017, 60: 1648-1661
 

NMR-Based Structural Integrity Analysis of Therapeutic Monoclonal Antibodies: A Comparative Study of Humira and Its Biosimilars
Baldisseri D, Luo S, Ancajas CAF, et al. mAbs. 2025;17(1):2551208

NMR Coupled with Multivariate Data Analysis for Monitoring the Degradation of a Formulated Therapeutic Monoclonal Antibody
Schaefer C, Cornet E, Piotto M. International Journal of Pharmaceutics. 2024;667:124894

Protein NMR of Biologicals: Analytical Support for Development and Marketed Products
Casagrande F, Dégardin K, Ross A. Journal of Biomolecular NMR. 2020;74(10):657-671

NMR Spectroscopy as a Characterization Tool Enabling Biologics Formulation Developmen
Ma J, Pathirana C, Liu DQ, Miller SA. Journal of Pharmaceutical and Biomedical Analysis. 2023;223:115110

Role of NMR in High Ordered Structure Characterization of Monoclonal Antibodies
Tokunaga Y, Takeuchi K. IJMS. 2020;22(1):46

Quantification of Natural Abundance NMR Data Differentiates the Solution Behavior of Monoclonal Antibodies and Their Fragments
Ban D, Rice CT, McCoy MA.. mAbs. 2021;13(1):1978132

Stability of a High-Concentration Monoclonal Antibody Solution Produced by Liquid–Liquid Phase Separation
Bramham JE, Davies SA, Podmore A, Golovanov AP. mAbs. 2021;13(1):1940666

Utility of High Resolution 2D NMR Fingerprinting in Assessing Viscosity of Therapeutic Monoclonal Antibodies
Majumder S, Bhattacharya DS, Langford A, Ignatius AA.. Pharm Res. 2022;39(3):529-539

Solid-State NMR Characterization of Lyophilized Formulations of Monoclonal Antibody Therapeutics
Perodeau J, Arbogast LW, Nieuwkoop AJ. Mol Pharmaceutics. 2023;20(3):1480-1489

Comprehensive Characterization of Higher Order Structure Changes in Methionine Oxidized Monoclonal Antibodies via NMR Chemometric Analysis and Biophysical Approaches
Li M, Beaumont VA, Akbar S, et al. mAbs. 2024;16(1):2292688

Application of NMR and Chemometric Analyses to Better Understand the Quality Attributes in pH and Thermally Degraded Monoclonal Antibodies
Beaumont VA, Liu L, Shi H, Rouse JC, Kim HY. Pharm Res. 2023;40(10):2457-2467

Ranking mAb–Excipient Interactions in Biologics Formulations By NMR Spectroscopy and Computational Approaches
Zhang C, Gossert ST, Williams J, et al. mAbs. 2023;15(1):2212416

Protein NMR of Biologicals: Analytical Support for Development and Marketed Products
Casagrande F, Dégardin K, Ross A. J Biomol NMR. 2020;74(10-11):657-671

Understanding Molecular Interactions in Rafoxanide-Povidone Amorphous Solid Dispersions from Ultrafast Magic Angle Spinning NMR
Mingyue Li, Fan Meng, Yu Tsutsumi, Jean-Paul Amoureux, Wei Xu, Xingyu Lu, Feng Zhang & Yongchao Su, Mol Pharmaceutics 2020

 
Sensitivity Boosts by the CPMAS CryoProbe for Challenging Biological Assemblies
Alia Hassan et al., J Magn Reson 2020, 311: 106680

 
1H NMR Relaxation Study to Evaluate the Crystalline State of Active Pharmaceutical Ingredients Containing Solid Dosage Forms Using Time Domain NMR
K Okada et al., J Pharm Sci 2019, 108: 451-456

 
1Quantitative Component Analysis of Solid Mixtures by Analyzing Time Domain 1H and 19F T1 Saturation Recovery Curves (qSRC)
Dirk Stueber and Stefan Jehle, J Pharm Sci 2017, 106: 1828-1838