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Journal Club

Check our new journal club space for scientific papers that we find interesting and currently relevant!

COVID-19

Current Status of Potential Therapeutic Candidates for the COVID-19 Crisis
Jiancheng Zhang, Bing Xie and Henji Hashimoto, Brain Behav Immun 2020

Thoughts on What Chemists Can Contribute to Fighting SARS‐CoV‐2 – A Short Note on Hand Sanitizers, Drug Candidates and OutreachTill Opatz, Joerg Senn-Bilfinger and Clemens Richert, Angew Chem Int Ed 2020, 59: 2–7

Developing Therapeutic Monoclonal Antibodies at Pandemic Pace
Brian Kelley, Nat Biotechnol 2020, 38: 540–545

The Race for Coronavirus Vaccines: a Graphical Guide
Ewen Callaway, Nature 2020, 580: 576-577

The COVID-19 Vaccine Development Landscape
Tung Thanh Le, Zacharias Andreadakis, Arun Kumar, Raúl Gómez Román, Stig Tollefsen, Melanie Saville & Stephen Mayhew, Nat Rev Drug Discov 2020, 19: 305-306

SARS and NMR


Signal Amplification by Reversible Exchange for COVID-19 Antiviral Drug Candidates
HyeJin Jeong et al., ChemRxiv. 2020
Preprint revised on April 06, 2020

Nuclear Magnetic Resonance Structure Shows that the Severe Acute Respiratory Syndrome Coronavirus-Unique Domain Contains a Macrodomain Fold
Amarnath Chatterjee, Margaret A. Johnson, Pedro Serrano, Bill Pedrini, Jeremiah S. Joseph, Benjamin W. Neuman, Kumar Saikatendu, Michael J. Buchmeier, Peter Kuhn & Kurt Wüthrich, Journal of Virology 2009, 83: 1823-1836

 
NMR Structure and Localization of a Large Fragment of the SARS-CoV Fusion Protein: Implications in Viral Cell Fusion
Mukesh Mahajan et. al., Biochim Biophys Acta Biomembr 2018, 1860: 407-415

 
Synthesis of Remdesivir Including Characterisation by NMR

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
Dustin Siegel, et. al., J Med Chem 2017, 60: 1648-1661
 

Biologics


Best Practices in Utilization of 2D-NMR Spectral Data as the Input for Chemometric Analysis in Biopharmaceutical Applications
Robert G. Brinson, Luke W. Arbogast, John P. Marino, Frank Delaglio, J Chem Inf Model 2020, 60(4): 2339-2355

An NMR Based Similarity Metric for Higher Order Structure Quality Assessment among U.S. Marketed Insulin Therapeutics
D. Wang, J. Park, S.M. Patil, C.J. Smith, J.L. Leazer Jr, D.A. Keire, K. Chen, J Pharm Sci 2020, 109(4): 1519-1528

Enabling Adoption of 2D-NMR for the Higher Order Structure Assessment of Monoclonal Antibody Therapeutics
Robert G. Brinson, et al., mAbs 2019, 11(1): 94-105
 
What NMR Can Do in the Biopharmaceutical Industry
Róbert Kiss, Ádám Fizil, Csaba Szántay Jr., J Pharm Biomed 2018, 147: 367–377

Precision and Robustness of 2D-NMR for Structure Assessment of Filgrastim Biosimilars
H. Ghasriani, D.J. Hodgson, R.G. Brinson, I. McEwen, L.F. Buhse, S. Kozlowski, J.P. Marino, Y. Aubin, D.A. Keire, Nat Biotechnol 2016, 34: 139–141