This presentation was originally delivered at TIDES Asia 2026.
Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful and versatile tool for structural characterization, offering atomic-level resolution, sensitivity to subtle (stereo)chemical differences, and inherently quantitative data. As biopharma shifts toward complex modalities such as peptides and antisense oligonucleotides (ASOs), collectively referred to as TIDES, recent advances in NMR technology, including the Multi Nuclear Inverse (MNI) probe, enable improved sensitivity and resolution for challenging biomolecules, supporting insight into conformation, stereochemistry, and molecular interactions across development and selected QC and characterization activities.
Thursday, February 26 2026
2:15 PM JST
As patents on key peptide therapeutics near expiration, there is increasing pressure to develop both next-generation molecules and high-quality generics, requiring analytical methods that are robust, precise, and scalable across discovery, development, and manufacturing. This presentation explores how NMR, supported by technologies such as the MNI probe, contributes to the structural characterization of peptide and ASO therapeutics, illustrated through real-world case studies from the TIDES landscape.