Enhancement of fluorescence with gold nanoparticles. The three-axis scan stage of the AFM head is used to align the AFM tip with the optical axis. The fluorescence and AFM images are recorded by raster-scanning the sample.
A. Bek, R. Jansen, M. Ringler, S. Mayilo, T. A. Klar, J. Feldmann. Fluorescence enhancement in hot spots of AFM-designed gold nanoparticle sandwiches. Nano Lett. 2008, 8, 485-490.
TERS mapping on fixed single human colon cancer cells (HT29 in liquid); Raman data analysis by hyperspectral unmixing algorithm N-FINDR.
M. Richter, M. Hedegaard, T. Deckert-Gaudig, P. Lampen, V. Deckert: “Laterally resolved and direct spectroscopic evidence of nanometer-sized lipid and protein domains on a single cell”, Small 7(2): 209 (2011)