Clarity PET Reconstruction Software | Fast, Quantitative Preclinical PET Imaging

Highlights

Bruker Clarity PET Reconstruction is a new software toolset for advanced PET reconstruction powered by Bruker’s true DOI measurement detector technology. Bruker Clarity features state of the art algorithms, real time reconstruction and integrated advanced corrections, all fine-tuned as part of ready to use application specific imaging protocols or as user selectable.

Bruker Clarity’s exclusive algorithms run a GPU cluster for ultra-fast reconstructions. Bruker Clarity is the new advanced PET Reconstruction toolset within the ParaVision 360 ecosystem, and it unifies PET/CT and PET/MR workflows for operational excellence.

Features

Full‑FOV accuracy with true DOI technology delivers high‑resolution, fast PET images for multi‑animal and whole‑body scans under realistic lab conditions.
Flexible reconstruction algorithms (MLEM, OSEM, FBP) enable the ideal speed‑to‑noise balance for low‑count studies and fine anatomical structures.
Real‑time online reconstruction provides live feedback during acquisition on the scanner and in ParaVision Workplace, reducing failed scans and enabling immediate protocol adjustments.
GPU‑accelerated performance completes standard reconstructions in ~2 minutes, fully quantitative attenuation‑corrected scans in ~4 minutes, and highest‑resolution MAP reconstructions in ~20 minutes.
MAP is available for OSEM and MLEM with selectable priors (Quadratic & Total Variation) and a user selectable hyperparameter to allow high iterations yet keeping noise low.
Integrated physical corrections (PSF, PVC, SSS scatter correction) deliver accurate SUVs and uptake values to strengthen quantitative confidence in publications and grant applications.
Anatomy‑guided Bowsher Prior preserves small‑structure detail—especially critical for neuroimaging—while maintaining quantitative accuracy and ROI‑level confidence.

Bruker’s unique PET technology characterizes the scintillation light distribution of each detected event to measure the depth of interaction.

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This video shows the GUI of Bruker Clarity PET Reconstruction as integrated in ParaVision 360.

Benefits

Accelerate reconstruction without compromising quality.

Achieve higher image fidelity and quantitative accuracy while dramatically speeding up reconstruction workflows and enabling real‑time decisions during acquisition.

The result is higher throughput, fewer re‑scans and failed sessions, lower operational costs, and reproducible, publication‑ready data. Faster cohort completion and improved consistency also support better 3Rs outcomes, with less handling and stress per animal.

Why it matters

Shorter research cycles through faster, high‑fidelity reconstructions
Stronger quantitative confidence and more robust conclusions
Fewer failed experiments and re‑scans, reducing time and cost
High‑quality images for grants, publications, and presentations
Greater confidence that the biology was captured correctly the first time

Touchscreen: Experiment Planning & Online reconstruction

Video based experiment planning is faster than regular Scout View and safer for the animal as it avoids the X-ray dose

Assess the biodistribution of your target radiotracer as the acquisition takes place.
Real-time decision-making based on list-mode reconstruction means you can rest assured that your injection went well or receive early information to decide whether to modify your study.

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Courtesy of CRL Small Animal Imaging Services team in Kuopio, Finland

Reconstruction Time Performance

In vivo reconstruction times Mouse [18F]FDG 3 MBq, 10 min acq.	Bruker Clarity PET Reconstruction in the PET/CT Si78	Typical Preclinical PET/CT System
Quick Preview	< 1 min	< 1 min
Standard Resolution	~ 2 min	~ 20 min
Highest Resolution	~ 25 min	> 1.5 hour

Fast reconstructions are achieved even with the highest quality settings enabled, thanks to:

DOI-corrected list-mode data, eliminating the need for time-consuming modeling or simulations
Highly efficient implementations of established reconstruction algorithms
Multiple GPU acceleration

4 x GPU Cluster

Bruker’s Unique Truly Measured DOI achieves high resolution across entire FOV
_{Case Study 1: 18F-FDG PET/CT in 4 Mice with neuro focus}

• Highly resolved mouse brain subregions/features.

• 20 min acquisition. MLEM-MAP 18 iterations & 0.25 mm voxel size

Bruker’s Unique Measured DOI achieves high resolution across entire FOV
_{Case Study 2: 18F-NaF PET/CT in 4 Mice with focus on bones}

• Highly resolved mouse ribcages

• 20 min acquisition. MLEM 18 iterations & 0.25 mm voxel size

0.7 mm Spatial Resolution

Mini Derenzo. 5 MBq 18F-FDG, 1 hour acquisition time, MLEM 0.25 mm, 200 it. PSF & PVC Activated.

F18-NaF PET Mouse Skeleton: Small Structures & High Statistics.

Best Reconstruction: OSEM-MAP 1it 0.25 mm.
PSF/PVC provides contrast and details for small features such as knee joints and is significantly faster than MLEM/MAP.

Low dose F18-FDG PET Mouse Brain: Small Structures & Low Statistics.

Best Reconstruction: MLEM-MAP 18it 0.25 mm PSF/PVC.
The image is sharp even at low counts and relatively high iteration numbers.

Anatomy Guided Reconstruction

^{Courtesy of Samuel Valable & Mikaël Naveau, Cyceron, Caen, France}

Bowsher Prior for MAP Reconstruction, dramatically increases image quality using an anatomical MRI o CT image.