核磁共振波谱法测定新冠病毒RNA 成分的二级结构

Chemical exchange saturation transfer (CEST) is a type of contrast mechanism that is becoming increasingly popular in the field of magnetic resonance imaging (MRI) for convenient, non-invasive quantitative imaging.
This webinar took place on September 24th 2020

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总览

抗击新冠病毒引起的全球大流行病是当前社会和科学面临的最大挑战。德国法兰克福大学核磁共振研究小组发起倡议,于2020年3月底成立了一个由30个小组组成的国际联盟。利用核磁共振波谱,他们正在针对所有与新冠病毒相关的蛋白质进行结构检测,而其中的RNA成分则正在形成新型药物的潜在靶点。 

此外,他们将用RNA和蛋白质来筛选一个片段数据库,这个片段库是为了便于后续化学操作而设计的。(在本次研讨会中)我们专注于本项目的RNA部分,还将介绍项目的生化背景、核磁共振分配策略,并展示我们的筛选结果。 

What to expect

An introduction to the CEST MRI technique will be followed by a description of its applications in brain ischemia and cancer. A demonstration will be given to show how a basic experiment can be performed and how measuring protein, acid, and metabolite content can be so beneficial. The presentation will be followed by a breif overview of the CEST method introduced in ParaVision 360.

Key Points

  • Introduction to CEST MRI for assessing disease parameters in brain cancer and ischemia
  • How CEST compliments Bruker’s MRI/PET instruments
  • • Assessing tumor metabolism using CEST
  • Bruker BioSpin's new CEST method now available in ParaVision 360
  • The upcoming CEST 2020 and CEST 2021 meetings, where more can be learned about this product and CEST MRI applications

Who should attend?

This webinar will appeal to any researchers and physicians interested in CEST techniques and the 2020 and 2021 CEST meetings. The many applications of this technique will mean anyone in the MRI field, especially physicists, will benefit from learning more about this development.

Speakers

Dr. Kristin Granlund
Dr. Kristin Granlund
MRI Applications Scientist Bruker
Dr. Kristin Granlund is an MRI Applications Scientist at Bruker USA. Prior to joining Bruker, she was a postdoctoral fellow at Memorial Sloan Kettering Cancer Center. Working with Dr. Kayvan Keshari, she developed methods for imaging in vivo cancer metabolism using hyperpolarized pyruvate.
Marty Pagel, PhD
Marty Pagel, PhD
Professor - Cancer Systems Imaging & Imaging Physics MD Anderson Cancer Center
Dr. Marty Pagel has focused on molecular imaging research during the last 20 years in industry and academia. He is a Professor in the Departments of Cancer Systems Imaging and Imaging Physics at the University of Texas MD Anderson Cancer Center. In addition, Dr. Pagel has held leadership positions in professional societies, funding agencies, and scientific journals that focus on molecular imaging. Dr. Pagel’s current research focuses on photoacoustic imaging, CEST MRI, DCE MRI, and PET/MRI, for studies with mouse models of cancer and for clinical trials with cancer patients.