Join Bruker's Virtual Seminar on March 9th during the US HUPO Virtual Conference being held March 8 - 12, 2021. Below are the details for the talks taking place. We hope you will join us. Also be sure to click the “Posters” tab to see the latest from Bruker’s Mass Spec application’s team.
Computationally, real-time database search in proteomics has been difficult because the time to search and assign a fragment ion spectrum to a peptide sequence can take longer than the rate of acquisition. This is particularly true when the search space is large including PTMs or semi-specific search parameters. Here, using massively parallelized search capabilities on a GPU called PaSER we can effectively perform the database search at the same rate as data acquisition, even under difficult search parameters including PTMs and enyme specificity. Additionally, in this talk we will describe the extended capabilities of the timsTOF Pro in prm-PASEF and dia-PASEF modes.
*in order to participate with the US HUPO conference and workshops, you must be registered with US HUPO
Chris Adams, PhD
Business Development Bioinformatics,
Productive biomarker discovery studies are resource-limited requiring complex workflows that operate with trade-offs in throughput, scalability, coverage, and precision. Thus, there is a need for new technological solutions for large-scale proteomic studies. Herein, we describe Proteograph™, a novel platform leveraging the nano-bio interactions of nanoparticles and their distinct biophysicochemical properties in forming protein coronas for deep and unbiased proteomic sampling.
Shadi Ferdosi, PhD
Scientist at Seer
Over 100 million people around the world have tested positive for the beta coronavirus SARS-CoV-2 from late 2019 to February 1st, 2021. COVID-19 has been characterized by elevated mortality with approximately 2.24 million deaths, primarily due to thrombo-inflammatory complications that impair lung perfusion and systemic oxygenation in the most severe cases. Over the same time period we developed a plasma proteomics pipeline using the Evosep One and timsTOF Pro system to explore systemic alterations in numerous injury and disease states. Similarities between COVID-19 and trauma, the number one cause of death for individuals under 45 with approximately 5.8 million annual deaths worldwide, lead to the exploration of a therapeutic intervention that activates the fibrinolytic system.
Kirk Hansen, PhD
Professor, University of Colorado
Biochemistry and Molecular Genetics
||Combining the accurate mass and time tag and ion mobility for label-free and missing peptide and analysis
|P08.13||CCS-centric protein identification Using IMS score||Bioinformatics|
|P04.05||Proteomic Profiling of IDH-mutant gliomas enables prediction of chromosomal copy numbers variations||Quant|
|P09.03||Open TIMS TimsPy TimsR: open access to timsTOF Pro raw data||Open Access Data|
||Implementation Of Holistic Glycopeptide PASEF-DDA Data in Diagnostics||Glycopeptides|
||Evaluation of prm-PASEF for multiplexed targeted proteomics
||Immune Suppression in the early state of COVID disease
||Novel biofunctional material coupled to PASEF enables sensitive extracellular vesicles phosphoproteomic analysis of urine samples
||A streamlined workflow for the quality control, interpretation and analysis of timsTOF Pro data - towards large-scale proteomics
||Computational simulation improves PASEF ion distribution of diaPASEF based proteomics
||Draft quantitative proteomic atlas of the human body carcinoma
||Real-time search of ubiquitin diGLY modified peptides and PaSER acquisition control on the timsTOF Pro
|P08.05||PimMDN: Peptide Ion mobility mixture density network
For Research Use Only. Not for use in clinical diagnostic procedures.