Webinar - 2021

Ultrasensitive NMR using DNP (Dynamic Nuclear Polarization):  Instruments, Methods & Applications

Webinar Overview

We are happy to announce webinars on solid-state DNP NMR that will give you insightful information into:

  • Introduction to Hyperpolarization and DNP for solid-state NMR
  • Overview of systems for DNP

×    Microwave sources:  Klystron at 400 MHz (263 GHz MW frequency) and Gyrotrons at 400 – 900 MHz (263 – 593 GHz).

×    Cooling systems & Probes:  Low-T (100 K) Magic Angle Spinning (MAS).

  • Sample Preparation & Radicals.
  • Key application examples

We will appreciate if you can spare your valuable time and register for these webinars.

Date: Tuesday, September 14, 2021

Time: 3:00 P.M. India Standard Time / 11:30 A.M. CEST

Duration: 1 hour, 15 minutes

Key Learning Points

  • Bruker is the longstanding leader in instruments, methods and applications for ultrasensitive NMR via the ‘hyperpolarization’ of nuclear spins. This refers generally to a large, non-equilibrium increase in the alignment of nuclear spins with a magnetic field, yielding correspondingly large gains in detection sensitivity for NMR.
  • The most widely used and versatile hyperpolarization method to date Low-Temperature Magic Angle Spinning (LT-MAS) Dynamic Nuclear Polarization (DNP) for solid-state NMR. DNP near 100 K provides signal enhancements of 10x to 300x. Combined with ultrastable LT-MAS, typically spinning the sample at frequencies of 8 – 65 kHz, high-quality spectral evaluation is possible on otherwise inaccessible systems, biomolecules (e.g., membrane proteins), small-molecules (e.g., pharmaceuticals) and materials (e.g, Li and Li+ batteries, polymers and nanoporous structures).
  • Bruker is the first and, by far, leading producer of commercial instrumentation for solids DNP, now approaching 50 installations worldwide. We will describe the instruments, sample-handling and DNP methods DNP, as well as key selected applications in the noted fields.


Jim Kempf, Ph.D

DNP & Hyperpolarizeation Product Development Manager, Bruker BioSpin Billerica, MA, USA

Jim Kempf started work in hyperpolarized NMR during his Ph.D. studies (1994-2000) at Caltech on optically pumped and detected NMR. In 2001, he completed a postdoc at Cornell on force-detected NMR, then in 2004 at Yale on solution-state biomolecular dynamics by NMR. In 2005, Jim joined the Chemistry faculty of at Rensselaer (RPI), leading a research programs in both biomolecular dynamics and novel solids-state NMR methods. In 2012, he moved to Bruker to return his focus to ultrasensitive NMR methods. In 2016, he became Hyperpolarization Product Manager, focused on dissolution DNP and parahydrogen methods, and in 2021 moved into his current position with enhanced focus on solid-state DNP.

Fabien Aussenac, PhD

DNP Applications Manager, Bruker BioSpin

Fabien Aussenac began his NMR career during his Ph.D. research at the University of Bordeaux I after obtaining a Master of organic chemistry from Toulouse III University (France). He received a Ph.D. in biophysics with research focused on structural and dynamical characterization of biomimetic membrane models by solid state NMR. At the end of his Ph.D., Fabien joined Bruker in 2003 and began working as an application scientist in solid state NMR. Since 2012, he is involved in the development of innovative solid state Dynamic Nuclear Polarization applications, working with a 263 GHz DNP spectrometer at Bruker BioSpin, Wissembourg (France).