From Biological Exploration to Clinical Translation: Lipoproteins in Inflammation Response

Inflammation plays a pivotal role in the body’s defence against pathogens. It is part of a cascade of events that are crucial for maintaining organ and systemic homeostasis. While acute inflammatory responses are essential for combating infections, chronic inflammation is increasingly linked to the onset of various clinical conditions, including diabetes, atherosclerosis, cardiometabolic diseases, rheumatoid arthritis, and obesity.

Traditionally, C-Reactive Protein (CRP) has been the gold standard for assessing inflammation. However, recent studies highlight the importance of glycoproteins and lipoproteins in both acute and chronic inflammation. Notably, inflammation can alter the composition and influence the pro- or anti-inflammatory behaviour of HDL particles.

In this webinar, we will explore how Nuclear Magnetic Resonance (NMR*) technology provides robust, fine-grained measurements of glycoproteins and lipoproteins, offering a comprehensive inflammatory profile within minutes. Further, we will present how those models were translated to benchtop NMR spectrometers potentially revolutionizing the landscape of NMR lipoprotein measurements.

Join us for this insightful webinar and discover how our translational achievements in NMR technology are poised to revolutionize clinical research settings.

September 25, 2024 | 03:00 PM CEST

• Innovative NMR Techniques: Learn about our diffusion and relaxation-edited NMR experiments, which led to a model-free inflammatory panel featuring SPC1, SPC2, SPC3, GlycA, and GlycB peaks.
• Comprehensive Data Analysis: Discover how these five parameters enable the construction of a molecular multivariate map of acute and chronic inflammatory phenotypes across multiple disease and population cohorts (N = 5000).
• Translational Technology: Understand the potential of benchtop NMR spectrometers for predicting lipoprotein parameters and fractions.
• Clinical Research Applications: Learn how self-administered capillary blood samples can eliminate the need for venipuncture, opening new avenues for sampling in remote areas or for high-frequency longitudinal studies. 

• Gain insights into the latest advancements in inflammation disease research and NMR * technology.
• Learn how benchtop NMR could bring us closer to routine application.
• Explore the future of inflammation analysis with non-invasive, rapid, and accurate methods.

* Bruker NMR Instruments are for Research Use Only. Not for Use in Clinical Diagnostic Procedures

• Clinical researchers: Biologists, biochemists, and analytical scientists investigating or interested in expanding research into acute and chronic inflammation linked to the onset of cardiovascular disorders, metabolic syndrome, and related fields.
• Scientists working in human metabolomics research seeking to expand their expertise into standardized NMR-based Metabolomics.
• Graduate students and postdoctoral fellows: Those seeking advanced knowledge and practical skills in applying NMR in human health and inflammation disease.
• Industry professionals: Scientists and R&D personnel in pharmaceutical, biotechnology, and nutritional companies doing research and developing therapeutic and diagnostic solutions related to inflammation