Two Is Company, Four Is a Party: Mapping Inflammatory Fructose Metabolism Using a Multi-Animal Imaging Approach
Webinar Overview
Metabolic tracing in vitro supports the key design feature of [¹⁸F]4FDF: the C4-OH of fructose is metabolically inert, but necessary for the carbohydrate scission by aldolase that is as key step in fructolysis. In a mechanism paralleling [¹⁸F]-2-fluoro-2-deoxyglucose, [¹⁸F]4FDF is retained in highly fructolytic cells. The development of [¹⁸F]4FDF will be discussed in this presentation, with a methodological focus on dynamic PET/CT acquisitions using a 4-position mouse hotel that supported radiotracer evaluation in mouse models of inflammation and concussion. Our findings establish [¹⁸F]4FDF PET/CT as a robust tool for investigating inflammatory fructose metabolism in vivo, with potential applications in disease monitoring and therapeutic evaluation.
Thursday, 29 May 2025
04:00 PM CEST
Key Learning Points
- Role of fructose metabolism in inflammation
- [¹⁸F]FDG and [¹⁸F]4FDF
- High throughput in vivo PET/CT
Who Should Attend
This webinar will be of interest to multiple profiles in the community of biomedical research, especially those applying medical imaging techniques in the study of metabolism and inflammation. Clinicians, researchers, PhD students and postdocs as well laboratory technicians will find this webinar relevant.
Speaker
Adam J. Shuhendler
Department of Chemistry & Biomolecular Sciences, University of Ottawa Heart Institute
Dr. Adam Shuhendler is improving imaging-based diagnosis with advancements in molecular imaging and chemical biology. His lab at the University of Ottawa develops novel molecular and nanoparticle-based imaging agents to visualize early signs of disease using clinical imaging technologies such as MRI, PET, and optical coherence tomography.
Moderator
Todd Sasser, PhD
Head of Applications PCI, Americas Bruker BioSpin Billerica, Massachusetts
Todd Sasser is a Field Applications Scientist for Bruker Preclinical Imaging. He provides application support for in vivo imaging across a wide variety of disciplines from infection imaging, cancer biology, and probe development. He currently focuses on application development for the Albira PET/SPECT/CT system. Dr. Sasser studied at The University of Liverpool and The University of Hawaii and is currently a visiting scholar at The University of Notre Dame.