Two Is Company, Four Is a Party: Mapping Inflammatory Fructose Metabolism Using a Multi-Animal Imaging Approach
Webinar Overview
Metabolic tracing in vitro supports the key design feature of [¹⁸F]4FDF: the C4-OH of fructose is metabolically inert, but necessary for the carbohydrate scission by aldolase that is as key step in fructolysis. In a mechanism paralleling [¹⁸F]-2-fluoro-2-deoxyglucose, [¹⁸F]4FDF is retained in highly fructolytic cells. The development of [¹⁸F]4FDF will be discussed in this presentation, with a methodological focus on dynamic PET/CT acquisitions using a 4-position mouse hotel that supported radiotracer evaluation in mouse models of inflammation and concussion. Our findings establish [¹⁸F]4FDF PET/CT as a robust tool for investigating inflammatory fructose metabolism in vivo, with potential applications in disease monitoring and therapeutic evaluation.
Thursday, 29 May 2025
04:00 PM CEST
Key Learning Points
- Role of fructose metabolism in inflammation
- [¹⁸F]FDG and [¹⁸F]4FDF
- High throughput in vivo PET/CT
Who Should Attend
This webinar will be of interest to multiple profiles in the community of biomedical research, especially those applying medical imaging techniques in the study of metabolism and inflammation. Clinicians, researchers, PhD students and postdocs as well laboratory technicians will find this webinar relevant.