Case Study: Striatal Circuit Profiling of Novel Drugs in Neurodegenerative Disease
Benefit from direct, real-time neural circuitry data
In this case study, readers can expect to learn about how Inscopix platforms are used for more effective drug discovery. Hear how Inscopix technology readily captures powerful longitudinal information, from changes in individual cell and ensemble activity continuously over hours.
Readers can expect to learn more about:
- Inscopix technology enables high-resolution functional profiling of striatal circuits
- The nVista system for longitudinal calcium imaging in freely behaving animals
- The potential of deriving quantitative biomarkers from neural circuit data
- Inscopix’s integrated workflow streamlines complex experimental pipelines
The time is now for a more predictive approach to preclinical neurotherapeutic drug development
The Need
To discover the next generation of more effective therapies, neuroscientists need much better efficacy and side-effect models that transcend the well-established shortcomings of traditional behavioral and histological methods.
The Approach
Existing technologies for brain imaging in freely moving animals provide information either from one cell at a time, or give averaged, high-level information across whole brain regions.
Inscopix takes a different approach – and gives direct, real-time neural circuitry data at a single cell resolution from 100s to 1000s of neurons all at once. This is the critical intermediate scale of the neurocircuit, where ensembles of neurons act in concert to control behavior. Inscopix neural imaging technologies directly visualize the detailed function of the living, behaving brain – opening up a completely new, ultra-powerful, and highly relevant data type.
Key Benefits
- Data-driven readouts
- Link circuits, targets, and behavioral endpoints
- Longitudinal study design for acute or chronic testing
The Application
Inscopix has enabled a new type of translational research, where models are built and defined by the individual and ensemble activity of neurons and the precise temporal relationship between neural circuit activity and behavior. Our platform is primarily used in mice and rats, but has also been applied in other preclinical species including non-human primates. Our technology readily captures powerful longitudinal information, from changes in individual cell and ensemble activity continuously over hours to define an acute drug-neural activity response, to imaging across weeks or months to follow progression of disease pathology or adaptive response to chronic pharmacology.
The Inscopix platform is validated neurotechnology and has found powerful application in revealing the details of striatal function with relevance to Parkinson’s, Schizophrenia, Huntington’s and other diseases involving the basal ganglia.
Transform your neuroscience drug development
Inscopix is proud to partner with hundreds of laboratories worldwide to bring new and valuable insights to their research. We collaborate with a number of pharma and biotech companies in several ways, including supporting their internal use of Inscopix systems and analytics. We also conduct collaborative contracted research studies in our labs in Mountain View, CA. Contact us to start the conversation.
