Microbial Identification

MALDI Biotyper® sirius RUO System | MALDI Biotyper® sirius GP System

The "sirius" solution for extended research capabilities for microbiology


MALDI Biotyper® sirius System

Bruker, being a global leader in MALDI-TOF technology, continuously invests in development and improvement of its instrument portfolio. As a result, this new "sirius" member of the MALDI Biotyper family has been launched in the scope of broadening research capabilities, including resistance detection applications.


Updated electronics | enabling further system improvements

The new Bruker MALDI Biotyper® sirius comprises the widely appreciated high capacity vacuum system of the MALDI Biotyper smart, as well as its fast 200 Hz smartbeam™ lifetime* laser. 

Developments in the electronics have expanded the system’s capabilities to allow for positive and negative ion detection.

  • Lighter: only 75 kg / 165 lbs
  • Faster target exchange
  • LED strip to remotely observe system status
  • Positive/negative ion mode 

All inherited, improved and new features of the MALDI Biotyper® sirius are held inside a true benchtop system of only 75 kg, allowing easy implementation in the lab. The system is fully compatible with existing MALDI Biotyper® software, libraries and consumables for microbial identification and beyond.

Daily laboratory life has been simplified by an LED strip on the front housing, conveniently allowing a visual system status check from a remote place in the lab.

* Lifetime meaning 7 years or 500 million shots, whichever comes first.

Positive/negative ion mode

Negative ion mode MALDI-TOF MS reveals the phosphoethanolamine modification of lipid A in colistin-resistant E. coli variants - With courtesy from Gerald Larrouy-Maumus, Imperial College, London-UK

Routine microbial identification is performed using positive ion mode only. The negative ion mode broadens the microbial research applications for the MALDI Biotyper® sirius, such as the analysis of lipids.

An exciting new MALDI-TOF lipidomics research topic is the rapid detection of colistin resistance related modifications to lipid A in colistin-resistant bacteria such as Acinetobacter baumanii¹ or Escherichia coli².

¹Dortet L et al., 2018, Scientific Reports, Vol: 8, ISSN: 2045-2322
²Dortet L et al., 2018, Journal of Antimicrobial Chemotherapy, Vol: 73, Pages: 3359-3367, ISSN: 0305-7453


For General Purpose use [In the United States, Japan and Taiwan: For Research Use Only (RUO)].

Not for use in clinical diagnostic procedures. Please contact your local representative for availability in your country.

Mehr Informationen

As of May 2021, Bruker Daltonik GmbH is now Bruker Daltonics GmbH & Co. KG.

Related products


MALDI Biotyper® sirius one System (GP + RUO)

The new MALDI Biotyper® sirius one RUO System / MALDI Biotyper® sirius one GP System is the latest instrument in the market leading MALDI Biotyper product portfolio for rapid and accurate microorganism identification.

MALDI Biotyper® Library RUO

The principle behind identification of microorganisms with the MALDI Biotyper® (MBT) is the comparison of the mass spectrum of an unknown organism with a library of reference mass spectra.

MBT Mycobacteria RUO Module

The genus Mycobacterium includes the important pathogens of the Mycobacterium tuberculosis complex (MTC) and the nontuberculous mycobacteria (NTM). NTM are increasingly the cause of opportunistic infections among immuno-compromised patients. This trend and the rise of antibiotic resistance in this genus demand improved differentiation among mycobacterium species.

MBT Filamentous Fungi Library

MALDI Biotyper (MBT) provides high differentiation power for identification of filamentous fungi.

MBT Subtyping Module (RUO)

The MBT Subtyping Module combines the identification of important pathogens with automated subsequent detection of specific marker peaks, all in one workflow, for differentiation of closely related species or resistance marker detection.
MBT Biotarget 96_highres

Consumables & Accessories for GP and RUO Systems

Consumables & Accessories optimizing microbial identification workflows

MBT Lipid Xtract Kit (RUO)

The MBT Lipid Xtract™ Kit facilitates efficient sample preparation for analysis of microbial lipids, enabling fast resistance detection based on MALDI-TOF analysis of Lipid A modifications, on the MALDI Biotyper® sirius, using negative ion mode.