Microbial Identification

MALDI Biotyper® sirius System 

The must-have for microbiology

The MALDI Biotyper® sirius System: unveiling new horizons in microbial analysis

As a global leader in MALDI-TOF mass spectrometry, Bruker continually enhances the functionalities of its comprehensive solutions. The MALDI Biotyper stands as a cornerstone technology, adeptly tackling the escalating challenges encountered in modern microbiology laboratories. This reliable tool is tailored to address the distinctive requirements of various microbiological market segments, spanning clinical, pharmaceutical, and diverse industries. Simultaneously, it paves the way for pioneering scientific exploration.

Rapid results for increasing demands
Swift analysis of 600 samples/hour
Top-level excellence with IDealTune™ 
Effortless system optimization,
without any extra cost or effort
Advancing microbial innovations
with both positive and negative ion mode capabilities

Enhanced capabilities

The Bruker MALDI Biotyper sirius System harnesses the cutting-edge technology that has made its predecessors so highly regarded. Equipped with a high-capacity vacuum system and a rapid smartbeam™ lifetime* laser, this system is primed for exceptional operation. 

*Lifetime refers to 7 years or 500 million shots, whichever comes first.
** Negative ion mode is for Research Use Only

The system's capabilities have been broadened, enabling seamless positive and negative** ion detection. This expansion opens doors to a wider range of applications and research possibilities.

Lighter, faster, and more intuitive

Weighing in at a mere 75 kg (165 lbs), the MALDI Biotyper sirius System is a true benchtop marvel. Its compact design facilitates effortless integration into any laboratory setup, including LIS-connection. The system's user-friendly workflows and features including rapid target exchange and an integrated LED strip, provide enhanced convenience and efficiency in your daily operations.


The intuitive MBT Compass HT Software packages have been designed to enhance the performance and security of your MALDI Biotyper System, while bringing the system’s speed and efficiency to new heights, enabling fast analysis of up to 600 samples per hour. MBT Compass HT reassures the MALDI Biotyper sirius System’s performance being kept at top level with the novel zero-button IDealTune™ feature - the perfect solution for effortless performance optimization, without any extra cost or effort.

Positive/Negative Ion Mode: unveiling new dimensions and supporting collaborative progress

Our revolutionary MALDI Biotyper sirius System is not limited to routine microbial identification. While positive ion mode remains a cornerstone for everyday analysis, the introduction of negative ion mode opens up exciting avenues in microbial research. Dive into cutting-edge lipidomics investigations, uncovering new insights and rapid detection techniques for e.g. resistance-related modifications of lipid A in colistin-resistant bacteria. 1,2

Join the ranks of visionary researchers who are revolutionizing microbial analysis. With the MALDI Biotyper sirius System, you gain access to a world of possibilities.

¹Dortet L et al., 2018, Scientific Reports, Vol: 8, ISSN: 2045-2322
²Dortet L et al., 2018, Journal of Antimicrobial Chemotherapy, Vol: 73, Pages: 3359-3367, ISSN: 0305-7453

Negative ion mode MALDI-TOF MS reveals the phosphoethanolamine modification of lipid A in colistin-resistant E. coli variants - With courtesy from Gerald Larrouy-Maumus, Imperial College, London-UK

A solution for every microbiology lab

The MALDI Biotyper sirius System is available in four different solution packages. Please contact your local representative for availability in your country:

MALDI Biotyper sirius IVD System

An IVD CE system for in vitro diagnostic identification of microorganisms originating from human specimens.

For professional use only. Not for sale in the USA.

MALDI Biotyper sirius CA System

Cleared USA FDA approval under Section 510(k) for the identification of gram-negative and gram-positive bacteria, anaerobic bacteria and yeast, cultured from human specimens.

Only for sale in the USA and Puerto Rico. For prescription use only.

MALDI Biotyper sirius RUO System

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