NMR for (Bio)Process Analytical Technology (PAT) Control
High- and low-field NMR enable PAT with high sensitivity and resolution, real-time reaction and bioprocess monitoring, and integration to support compliance.
NMR is integral to (Bio)Process Analytical Technology (PAT), providing high sensitivity and resolution for monitoring, understanding, and optimizing chemical and bioproduction workflows. The integration of flow-compatible solutions, such as the InsightMR tube - adaptable for both high-field and low-field NMR - enables real-time, application-specific process monitoring.
These platforms deliver continuous spectral data, allowing researchers to assess conditions in real time, resolve challenges promptly, and fine-tune reaction or fermentation processes to maximize yield and maintain product integrity.
NMR-based PAT streamlines the transition from laboratory development to manufacturing, ensuring consistent performance and reproducibility across different production scales.
The Fourier PAT benchtop system advances these benefits through robust spectral analysis and seamless data integration, enhancing process control and supporting regulatory compliance with orchestration software like synTQ.
High-field NMR PAT offers heightened sensitivity and resolution, detecting low-abundance species and facilitating detailed analysis of complex mixtures. This capability supports advanced reaction monitoring and deeper bioprocess insights.
Collectively, these NMR technologies contribute to precise process control and accelerated development in alignment with Quality by Design (QbD) principles, supporting more efficient, scalable, and forward-thinking solutions for the pharmaceutical and biotechnology sectors.
