EPRW 2022

September 19-23, 2022

Bologna, Italy

Introduction

Introduction

Join us at EPRW 2022 in Bologna and listen to our vendor session. Don't forget to come and visit us at booth no. 4 in the exhibition and get the latest news on our products and applications.

We are looking forward to welcome you in Bologna!

Vendor Session

September 20, 13:20-13:55 pm

TargetScreener 4D: How trapped ion mobility spectrometry can help to gain confidence in the analysis of contaminants in food extracts

Dr. Carsten Baessmann, Director of Solutions Development Applied Markets, Bruker Daltonics GmbH & Co. KG, Bremen, Germany

Abstract:
The maximum residue levels (MRL) permitted for pesticides and other chemical residues in food and feedstuffs are strictly controlled by local and international regulatory bodies. One of the most important aspects in reducing pesticide exposure is to monitor their levels in food extracts. However, with increasing demands for lower detection thresholds to cover hundreds of pesticides originating from numerous sample types, accurate and reliable pesticide screening is a critical and complex analytical task. In recent years, UHPLC-QTOF and GC-APCI-QTOF-based solutions have been used successfully to address this challenge.

In this study we evaluate the additional benefit of using Trapped Ion Mobility Spectrometry (TIMS) and collisional cross section (CCS) in addition to retention time, accurate mass, isotopic pattern, and MS/MS qualifier ions. For this purpose, QuEChERS extracts (onion, rye, orange) containing pesticides at different concentrations were analyzed using an Elute UHPLC connected to a timsTOF Pro 2 using a VIP-HESI source (all Bruker Daltonics). Alternatively, dioxins or pesticides more amendable to GC/MS could be analyzed using GC-APCI-timsTOF. Automated processing was performed using TASQ 2022b. 

The analysis of selected samples by disabling and enabling TIMS, indicated that full-scan MS and bbCID MS/MS spectra of significantly higher quality were acquired when utilizing TIMS. After ion mobility filtration, more ‘clear’ mass spectra were provided even in highly complex matrices. Moreover, lower detection limits were achieved since the signal-to-noise ratios of precursor ions, adducts, and fragments were increased, and isotopic pattern fitting was improved. Thus, the incorporation of TIMS into LC-HRMS was proved to yield superior qualitative and quantitative results.

Dr. Carsten Baessmann, Director of Solutions Development Applied Markets, Bruker Daltonics GmbH & Co. KG, Bremen, Germany

Dr. Carsten Baessmann is responsible for the development of new mass spectrometry-based solutions in the applied markets. His responsibilities include managing collaborations with leading researchers in food, environmental, forensics and clinical analysis. He is also responsible for driving the necessary hardware and software development. Dr. Baessmann holds a Ph.D. in physical chemistry from the Technical University of Munich in the development of new mass spectrometric and laser spectroscopic methods for environmental research. He has held various management positions in research and development and application development at Bruker for 25 years.

 

For Research Use Only. Not for use in clinical diagnostic procedures.