Live from the Lab at Sapient:
How timsTOF is helping to transform the speed and scale of small molecule biomarker discovery

October 13, 2022, 10 am PST

Live Lab

Join us on this live lab tour to learn how Sapient’s next-generation, ultra-high throughput rapid liquid chromatography-mass spectrometry (rLC-MS) platform leverages the unique bioanalytical capabilities of the Bruker timsTOF Pro 2 to enable large-scale biomarker profiling. See how the systems perform nontargeted measurement of >11,000 circulating small molecule biomarkers per biosample across thousands of samples at a time.

Discover how these instruments offer:

  • Sensitivity to capture broad chemistries, including thousands of uncharacterized novel factors
  • Comprehensive 4D chemical classification within a cycle time of <1 minute

The Sapient team will also show you how these technologies are embedded within a larger integrated discovery pipeline that allows for rapid identification and cross-validation of new biomarkers across broad, diverse populations.

Speaker

Mohit Jain, M.D., Ph.D., Founder and CEO, Sapient, San Diego, CA, USA

Dr. Jain is a physician-scientist with nearly 20 years of expertise in physiology, biomedicine, engineering, computational biology, and mass spectrometry-based metabolomics. Prior to founding Sapient, he formed and was director of Jain Laboratory at the University of California San Diego (UCSD). There he led a multi-disciplinary research team to develop next-generation rapid liquid chromatography-mass spectrometry (rLC-MS) systems to probe the non-genetic landscape of disease across population-scale human studies. His work was supported by the National Institutes of Health Outstanding New Environmental Scientist (ONES) Program grant and over $30M in federal, foundation, and industry funding.

Dr. Jain founded Sapient in 2021 as a spinout of Jain Laboratory to expand upon the mission of accelerating human discovery and drug development through the nexus of high throughput analytical mass spectrometry, computational biology, and population-scale biomarker profiling.

Dr. Jain has held faculty positions at UCSD since 2013, most recently as a Professor of Medicine and Pharmacology. He obtained his MD and PhD from Boston University School of Medicine, and performed clinical residency and fellowship training in Internal Medicine, Cardiology, and Preventative Cardiology at Brigham and Women’s Hospital, Harvard Medical School.

Jeramie Watrous, Ph.D., Co-Founder and Head of Analytical R&D, Sapient, San Diego, CA, USA

Dr. Watrous is an analytical chemist and engineer with more than a decade of experience using mass spectrometry for small metabolite measures and associated informatics, both in academia and industry environments. Prior to co-founding Sapient, he was a postdoctoral researcher and subsequently an Assistant Professor of Medicine at Jain Laboratory at the University of California San Diego (UCSD). During this time, he was responsible for developing fully automated, high throughput mass spectrometry-based workflows for global small molecule analysis in biological fluids. Dr. Watrous was also previously a scientist at Watson Pharmaceuticals, where he developed cGMP analytical testing methods for emerging generic drugs. At Sapient, Dr. Watrous is responsible for the generation, optimization, and standardization of Sapient’s rLC-MS systems and other innovative instrumentation and lab automation infrastructure.

Dr. Watrous earned his undergraduate degree in Bioanalytical Chemistry from California State University-San Bernadino and received his MS and PhD in Bioanalytical Chemistry from UCSD.