MRMS Bibliography

Introduction

MRMS Metabolomics and Imaging Bibliography

The MRMS technology is used in Metabolomics to study metabolites in plants, body fluids as well as in bacteria and yeast. MALDI Imaging is a technology that can be perfectly perform with high mass accuracy using the MRMS system. Imaging can be applied to human and animal tissue samples as well as plant samples. An overview of the literature of both technologies is shown here.

Metabolomics

Metabolomics - Plants and Food

Title Authors Publication Link
Olive Oil Quality and Authenticity Assessment Aspects Employing FIA-MRMS and LC-Orbitrap MS Metabolomic Approaches T. Nikou et al. Frontiers in Public Health 2020, Volume 8, Article 558226 https://www.frontiersin.org/articles/10.3389/fpubh.2020.558226/full
Expanding the Scope of Detectable Microbial Natural Products by Complementary Analytical Methods and Cultivation Systems C. Bader et al. J. Nat. Prod. 2021, 84, 2, 268–277 https://pubs.acs.org/doi/10.1021/acs.jnatprod.0c00942
Chemical Fingerprinting of Conifer Needle Essential Oils and Solvent Extracts by Ultrahigh-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry O. O. Mofikoya et al. ACS Omega 2020 5 (18), 10543-10552 https://pubs.acs.org/doi/10.1021/acsomega.0c00901
Wine aging: a bottleneck story T. Karbowiak et al. npj Science of Food 3, 14 (2019) https://www.nature.com/articles/s41538-019-0045-9
Wine microbiology is driven by vineyard and winery anthropogenic factors C. Grangeteau et al. Microbial Biotechnology (2017) 10(2), 354–370 https://sfamjournals.onlinelibrary.wiley.com/doi/10.1111/1751-7915.12428
The chemodiversity of wines can reveal a metabologeography expression of cooperage oak wood R. D. Gougeon et al. PNAS 2009 106 (23) 9174-9179 https://www.pnas.org/content/106/23/9174
A grape and wine chemodiversity comparison of different appellations in Burgundy: Vintage vs terroir effects C. Roullier-Gall et al. Food Chem. 2014, 152, 100-107 https://www.sciencedirect.com/science/article/abs/pii/S0308814613016907
A Multilevel Study of Melon Fruit Reticulation Provides Insight into Skin Ligno-Suberization Hallmarks H. Cohen et. al. Plant Physiology, 179, 4, 2019, 1486–1501 https://academic.oup.com/plphys/article/179/4/1486/6116732
Revisiting anabasine biosynthesis in tobacco hairy roots expressing plant lysine decarboxylase gene by using 15N-labeled lysine S. Bunsupa et al. Plant Biotechnol. 31(5): 511-518 (2014) https://www.jstage.jst.go.jp/article/plantbiotechnology/31/5/31_14.1008a/_article

Metabolomics - Plants

Title Authors Publication Link
Discrimination of Wine Attributes by Metabolome Analysis A. Cuadros-Inostroza et al. Anal. Chem. 2010, 82, 9, 3573–3580 https://pubs.acs.org/doi/10.1021/ac902678t
Unraveling different chemical fingerprints between a champagne wine and its aerosols G. Liger-Belair et al. PNAS, 2009, 106, 16545–16549 https://www.pnas.org/content/106/39/16545
The chemodiversity of wines can reveal a metabologeography expression of cooperage oak wood R. D. Gougeon et al. PNAS, 2009, 106, 9174–9179 https://www.pnas.org/content/106/23/9174
Exploring the chemical space of white wine antioxidant capacity: A combined DPPH, EPR and FT-ICR-MS study R. Romanet et. al. Food Chem. 355:129566 (2021) https://www.sciencedirect.com/science/article/abs/pii/S0308814621005720
Hidden in its color: A molecular-level analysis of the beer’s Maillard reaction network S. Pieczonka et. al. Food Chem. 361:130112 (2021) https://www.sciencedirect.com/science/article/abs/pii/S0308814621011183
On the Trail of the German Purity Law: Distinguishing the Metabolic Signatures of Wheat, Corn and Rice in Beer S. Pieczonka et. al. Front. Chem. 9:715372 (2021) https://www.frontiersin.org/articles/10.3389/fchem.2021.715372/full
Decomposing the molecular complexity of brewing S. Pieczonka et. al. npj Science of Food (2020) 4, 11 https://www.nature.com/articles/s41538-020-00070-3
Determination of soyasaponins in Fagioli di Sarconi beans (Phaseolus vulgaris L.) by LC-ESI-FTICR-MS and evaluation of their hypoglycemic activity G. Bianco et al. Anal. Bioanal. Chem. 410, 1561–1569 (2018) https://link.springer.com/article/10.1007/s00216-017-0806-8
In situ localization of micropollutants and associated stress response in Populus nigra leaves C. Vilette et. al. Environment International 126 (2019) 523–532 https://www.sciencedirect.com/science/article/pii/S0160412018324917

Metabolomics - Body Fluids

Title Authors Publication Link
Prenatal and Early Postnatal Cerebral d-Aspartate Depletion Influences l-Amino Acid Pathways, Bioenergetic processes, and Developmental Brain Metabolism M. Grimaldi et al. J. Proteome Res. 2021, 20, 1, 727–739 https://pubs.acs.org/doi/10.1021/acs.jproteome.0c00622
Ultrahigh-Resolution Mass Spectrometry-Based Platform for Plasma Metabolomics Applied to Type 2 Diabetes Research Y. Zhu et al. J. Proteome Res. 2021 20, 1, 463-473 https://pubs.acs.org/doi/10.1021/acs.jproteome.0c00510
Metabolomics Reveals Metabolic Biomarkers of Crohn's Disease J. Jansson et al. PLOS ONE 2009, 4, e6386 https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0006386
The compositional space of exhaled breath condensate and its link to the human breath volatilome F. Moritz et al. J. Breath Res. 9 027105 (2015) https://iopscience.iop.org/article/10.1088/1752-7155/9/2/027105
Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD T. Lee et al. Gut 2017;66:863–871 https://gut.bmj.com/content/66/5/863
Dietary fat and gut microbiota interactions determine diet-induced obesity in mice R. Kübeck et al. Mol Metab. 2016 Oct 13;5(12):1162-1174 https://www.sciencedirect.com/science/article/pii/S2212877816301892
Insulin Sensitivity Is Reflected by Characteristic Metabolic Fingerprints - A Fourier Transform Mass Spectrometric Non-Targeted Metabolomics Approach M. Lucio et al. PLOS ONE 2010, 5(10): e13317 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013317

Metabolomics – Animals, Yeast and Bacteria

Title Authors Publication Link
Direct injection Fourier transform ion cyclotron resonance mass spectrometric method for high throughput quantification of quinolones in poultry L. E. Ikkere, et al. Journal of Pharmaceutical and Biomedical Analysis 188 (2020) 113389 https://www.sciencedirect.com/science/article/abs/pii/S0731708520312759
Combination of UHPLC-MS/MS-molecular networking approach and FTICR-MS for the metabolic profiling of Saccharomyces cerevisiae O. Perruchon et al. Journal of Pharmaceutical and Biomedical Analysis 195 (2021) 113857 https://www.sciencedirect.com/science/article/abs/pii/S0731708520317441
Exploring yeast interactions through metabolic profiling C. Roullier-Gall et al. Sci Rep 10, 6073 (2020) https://www.nature.com/articles/s41598-020-63182-6
DI-ICR-FT-MS-based high-throughput deep metabotyping: a case study of the Caenorhabditis elegans–Pseudomonas aeruginosa infection model M. Witting et al. Analytical and Bioanalytical Chemistry 407, 1059–1073 (2015) https://link.springer.com/article/10.1007/s00216-014-8331-5
Marine sequestration of carbon in bacterial metabolites O. J. Lechtenfeld et al. Nature Communications 6, 6711 (2015) https://www.nature.com/articles/ncomms7711
Comprehensive Analysis of the Alternaria Mycobolome Using Mass Spectrometry Based Metabolomics M. Gotthardt et. al. Mol. Nutr. Food Res. 2020, 64, 1900558 https://onlinelibrary.wiley.com/doi/10.1002/mnfr.201900558

Metabolomics – Methods

Title Authors Publication Link
13C Isotope-Labeled Metabolomes Allowing for Improved Compound Annotation and Relative Quantification in Liquid Chromatography-Mass Spectrometry-based Metabolomic Research P. Giavalisco et. al. Anal. Chem. 2009, 81, 15, 6546–6551 https://pubs.acs.org/doi/10.1021/ac900979e
High-Resolution Direct Infusion-Based Mass Spectrometry in Combination with Whole 13C Metabolome Isotope Labeling Allows Unambiguous Assignment of Chemical Sum Formulas P. Giavalisco et. al. Anal. Chem. 2008, 80, 24, 9417–9425 https://pubs.acs.org/doi/10.1021/ac8014627
Potential of dynamically harmonized Fourier transform ion cyclotron resonance cell for high-throughput metabolomics fingerprinting: control of data quality B. Habchi et al. Analytical and Bioanalytical Chemistry, 410, 483–490 (2018) https://link.springer.com/article/10.1007%2Fs00216-017-0738-3
Ultrahigh resolution metabolomics for S-containing metabolites R. Nakabayashi et. al. Current Opinion in Biotechnology 2017, 43, 8–16 https://www.sciencedirect.com/science/article/pii/S0958166916301604
An Enhanced Isotopic Fine Structure Method for Exact Mass Analysis in Discovery Metabolomics: FIA-CASI-FTMS C. J. Thompson et al. J. Am. Soc. Mass Spectrom. 2020, 31, 10, 2025–2034 https://pubs.acs.org/doi/10.1021/jasms.0c00047

Imaging

Imaging – General Biology

Title Authors Publication Link
Lipid Dynamics due to Muscle Atrophy Induced by Immobilization K. Kimura et al. Journal of Oleo Science 2021, 70, 7, 937-946 https://www.jstage.jst.go.jp/article/jos/70/7/70_ess21045/_article
Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain T. Vallianatou et al. ACS Chemical Neuroscience 2021, 12, 10, 1811-1823 https://pubs.acs.org/doi/10.1021/acschemneuro.1c00103
Ocular phenotypes in a mouse model of impaired glucocerebrosidase activity M. Weber et al. Scientific Reports 2021, 11, 1, 6079 https://www.nature.com/articles/s41598-021-85528-4
GD3 synthase deletion alters retinal structure and impairs visual function in mice C. A. Abreu et al. Journal of Neurochemistry 2021, 158, 3, 694-709 https://onlinelibrary.wiley.com/doi/10.1111/jnc.15443
Brain glycogen serves as a critical glucosamine cache required for protein glycosylation R. C. Sun et al. Cell Metabolism 2021, 33, 7, 1404-1417.e9 https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00220-5
Multimodal Imaging Mass Spectrometry of Murine Gastrointestinal Tract with Retained Luminal Content Shows Molecular Localization Patterns E. R. Guiberson et al. bioRxiv 2021, preprint https://www.biorxiv.org/content/10.1101/2021.10.03.462819v1
Chelator sensing and lipopeptide interplay mediates molecular interspecies interactions between soil bacilli and pseudomonads S. Andric et al. bioRxiv 2021, pre-print https://www.biorxiv.org/content/10.1101/2021.02.22.432387v2
Mass spectrometry imaging reveals glycine distribution in the developing and adult mouse brain F. Eto et al. Journal of Chemical Neuroanatomy 2020, 110, 101869 https://www.sciencedirect.com/science/article/abs/pii/S0891061820301381
In situ metabolite and lipid analysis of GluN2D−/− and wild-type mice after ischemic stroke using MALDI MSI W. T. Andrews et al. Analytical and Bioanalytical Chemistry 2020, 412, 24, 6275-6285 https://link.springer.com/article/10.1007%2Fs00216-020-02477-z
In situ detection and imaging of lysophospholipids in zebrafish using matrix‐assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry K. He et al. Journal of Mass Spectrometry 2021, 56, 4, e4637 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.4637
Spatial Localization of Vitamin D Metabolites in Mouse Kidney by Mass Spectrometry Imaging K. W. Smith et al. ACS Omega 2020, 5, 22, 13430-13437 https://pubs.acs.org/doi/10.1021/acsomega.0c01697
Mass spectrometry imaging reveals differential localization of natural sunscreens in the mantle of the giant clam Tridacna crocea M. Goto-Inoue et al. Scientific Reports 2020, 10, 1, 656 https://www.nature.com/articles/s41598-019-57296-9
Localization of the lens intermediate filament switch by imaging mass spectrometry Z. Wang et al. Experimental Eye Research 2020, 198, 108134 https://www.sciencedirect.com/science/article/abs/pii/S0014483520303924
Region-specific effects of Scrapper on the abundance of glutamate and gamma-aminobutyric acid in the mouse brain F. Eto et al. Scientific Reports 2020, 10, 1, 7435 https://www.nature.com/articles/s41598-020-64277-w
Mapping glucose metabolites in the normal bovine lens: Evaluation and optimisation of a matrix‐assisted laser desorption/ionisation imaging mass spectrometry method A. Zahraei et al. Journal of Mass Spectrometry 2021, 56, 4, e4666 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.4666
Spatial segmentation and metabolite annotation involved in sperm maturation in the rat epididymis by MALDI Imaging mass spectrometry M. Lagarrigue et al. Journal of Mass Spectrometry 2020, 55, 12, e4633 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jms.4633
Imaging mass spectrometry to visualise increased acetylcholine in lungs of asthma model mice T. Matsuda et al. Analytical and Bioanalytical Chemistry 2020, 412, 18, 4327-4341 https://link.springer.com/article/10.1007%2Fs00216-020-02670-0
A micrometer‐scale snapshot on phototroph spatial distributions: mass spectrometry imaging of microbial mats in Octopus Spring, Yellowstone National Park L. Wörmer et al. Geobiology 2020, 18, 6, 742-759 https://onlinelibrary.wiley.com/doi/10.1111/gbi.12411
PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle H. Yoon et al. Cell Metabolism 2020, 32, 2, 215-228.e7 https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30318-1
A Global Cndp1-Knock-Out Selectively Increases Renal Carnosine and Anserine Concentrations in an Age- and Gender-Specific Manner in Mice T. Weigand et al. International Journal of Molecular Sciences 2020, 21, 14, 4887 https://www.mdpi.com/1422-0067/21/14/4887
Nonclinical applications of quantitative whole-body autoradiography, and imaging mass spectrometry in drug discovery and development E. G. Solon et al. Progress in Biomedical Optics and Imaging 2020, Vol. 11219, 1121903-1121903-13 https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11219/2551441/Nonclinical-applications-of-quantitative-whole-body-autoradiography-and-imaging-mass/10.1117/12.2551441.short
Epilipidomics of Senescent Dermal Fibroblasts Identify Lysophosphatidylcholines as Pleiotropic Senescence-Associated Secretory Phenotype (SASP) Factors M. Narzt et al. Journal of Investigative Dermatology 2020, 141, 4, 993-1006.e15 https://www.jidonline.org/article/S0022-202X(20)32367-8/fulltext
Mass spectrometry imaging of blast overpressure induced modulation of GABA/glutamate levels in the central auditory neuraxis of Chinchilla K. Zemaitis et al. Experimental and Molecular Pathology 2021, 119, 104605 https://www.sciencedirect.com/science/article/abs/pii/S0014480021000046

Imaging – Plant Biology

Title Authors Publication Link
Unveiling spatial metabolome of Paeonia suffruticosa and Paeonia lactiflora roots using MALDI MS imaging B. Li et al. New Phytologist 2021, 231, 2, 892-902 https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.17393
Analysis of Erythroxylum coca Leaves by Imaging Mass Spectrometry (MALDI–FT–ICR IMS) N. A. dos Santos et al. Journal of The American Society for Mass Spectrometry 2021, 32, 4, 946-955 https://pubs.acs.org/doi/10.1021/jasms.0c00449
Sclareol and linalyl acetate are produced by glandular trichomes through the MEP pathway C. Chalvin et al. Horticulture Research 2021, 8, 1, 206 https://www.nature.com/articles/s41438-021-00640-w
High spatial resolution imaging of the dynamics of cuticular lipid deposition during Arabidopsis flower development L. E. Alexander Plant Direct 2021, 5, 4, e00322 https://onlinelibrary.wiley.com/doi/10.1002/pld3.322
The metabolic environment of the developing embryo: A multidisciplinary approach on oilseed rapeseed H. Rolletschek et al. Journal of Plant Physiology 2021, 265, 153505 https://www.sciencedirect.com/science/article/pii/S0176161721001449
The GORKY glycoalkaloid transporter is indispensable for preventing tomato bitterness Y. Kazachkova et al. Nature Plants 2021, 7, 4, 468-480 https://www.nature.com/articles/s41477-021-00865-6
Spatial metabolomics using imaging mass spectrometry to identify the localization of asparaptine A in Asparagus officinalis R. Nakabayashi et al. Plant Biotechnology 2021, 38, 3, 311-315 https://www.jstage.jst.go.jp/article/plantbiotechnology/38/3/38_21.0504b/_article
A multimodal metabolomics approach using imaging mass spectrometry and liquid chromatography-tandem mass spectrometry for spatially characterizing monoterpene indole alkaloids secreted from roots R. Nakabayashi et al. Plant Biotechnology 2021, 38, 3, 305-310 https://www.jstage.jst.go.jp/article/plantbiotechnology/38/3/38_21.0504a/_article
Preserved and variable spatial‐chemical changes of lipids across tomato leaves in response to central vein wounding reveals potential origin of linolenic acid in signal transduction cascade D. Veličković, et al. Plant-Environment Interactions 2021, 2, 1, 28-35 https://onlinelibrary.wiley.com/doi/10.1002/pei3.10038
Maize Zmcyp710a8 Mutant as a Tool to Decipher the Function of Stigmasterol in Plant Metabolism S. I. Aboobucker et al. Frontiers in Plant Science 2021, 12, 732216 https://www.frontiersin.org/articles/10.3389/fpls.2021.732216/full
Localization of mercury and gold in cassava (Manihot esculenta Crantz) H. J. P. Alcantara et al. Environmental Science and Pollution Research 2020, 27, 15, 18498-18509 https://link.springer.com/article/10.1007%2Fs11356-020-08285-3
Unique and highly specific cyanogenic glycoside localisation in stigmatic cells and pollen in the genus Lomatia (Proteaceae) E. Ritmejerytė et al. Annals of Botany 2020, 126, 3, 387-400 https://academic.oup.com/aob/article/126/3/387/5802779
An approach for broad molecular imaging of the root-soil interface via indirect matrix-assisted laser desorption/ionization mass spectrometry D. Veličković et al. Soil Biology and Biochemistry 2020, 146, 107804 https://www.sciencedirect.com/science/article/abs/pii/S0038071720301012
Chemical characterization, antioxidant and antimicrobial activities of açaí seed (Euterpe oleracea Mart.) extracts containing A- and B-type procyanidins G. R. Martins et al. LWT 2020, 132, 109830 https://www.sciencedirect.com/science/article/abs/pii/S0023643820308197
Differential distribution of characteristic constituents in root, stem and leaf tissues of Salvia miltiorrhiza using MALDI mass spectrometry imaging S. Li et al. Fitoterapia 2020, 146, 104679 https://www.sciencedirect.com/science/article/abs/pii/S0367326X20302616
Rhizosphere microbiome mediates systemic root metabolite exudation by root-to-root signaling E. Korenblum et al. Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 7, 3874-3883 https://www.pnas.org/content/117/7/3874
Metabolomics should be deployed in the identification and characterization of gene‐edited crops P. D. Fraser et al. The Plant Journal 2020, 102, 5, 897-902 https://onlinelibrary.wiley.com/doi/10.1111/tpj.14679

Imaging – Other Applications

Title Authors Publication Link
Secret messaging with endogenous chemistry E. Kennedy et al. Scientific Reports 2021, 11, 1, 13960 https://www.nature.com/articles/s41598-021-92987-2
Mechanistic Insights Into Molecular Proxies Through Comparison of Subannually Resolved Sedimentary Records With Instrumental Water Column Data in the Santa Barbara Basin, Southern California S. Alfken et al. Paleoceanography and Paleoclimatology 2020, 35, 10, e2020PA004076 https://agupubs.onlinelibrary.wiley.com/doi/10.1029/2020PA004076
An annually resolved record of Western European vegetation response to Younger Dryas cooling I. Obreht et al. Quaternary Science Reviews 2020, 231, 106198 https://www.sciencedirect.com/science/article/pii/S0277379119311485
Moxidectin toxicity to zebrafish embryos: Bioaccumulation and biomarker responses M. S. Muniz et al. Environmental Pollution 2021, 283, 117096 https://www.sciencedirect.com/science/article/abs/pii/S0269749121006783

Imaging – Clinical, Other Applications

Title Authors Publication Link
MALDI Mass Spectrometry Imaging in a Primary Demyelination Model of Murine Spinal Cord E. R. Sekera et al. Journal of The American Society for Mass Spectrometry 2020, 31, 12, 2462-2468 https://pubs.acs.org/doi/10.1021/jasms.0c00187
Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice A. Aliluev et al. Nature Metabolism 2021, 3, 9, 1202-1216 https://www.nature.com/articles/s42255-021-00458-9
Targeted Expression of TGFBIp Peptides in Mouse and Human Tissue by MALDI-Mass Spectrometry Imaging V. Anandalakshmi et al. Separations 2021, 8, 7, 97 https://www.mdpi.com/2297-8739/8/7/97
Identification of a distinct lipidomic profile in the osteoarthritic synovial membrane by mass spectrometry imaging B. Rocha et al. Osteoarthritis and Cartilage 2021, 29, 5, 750-761 https://www.oarsijournal.com/article/S1063-4584(21)00038-8/fulltext
Muscle metabolic remodelling patterns in Duchenne muscular dystrophy revealed by ultra-high-resolution mass spectrometry imaging I. Dabaj et al. Scientific Reports 2021, 11, 1, 1906 https://www.nature.com/articles/s41598-021-81090-1
Integrative Metabolic Pathway Analysis Reveals Novel Therapeutic Targets in Osteoarthritis B. Rocha et al. Molecular & Cellular Proteomics 2020, 19, 4, 574-588 https://www.mcponline.org/article/S1535-9476(20)35018-0/fulltext
Maternal obesity alters placental lysophosphatidylcholines, lipid storage, and the expression of genes associated with lipid metabolism K. L. Bidne et al. Biology of Reproduction 2021, 104, 1, 197-210 https://academic.oup.com/biolreprod/article/104/1/197/5922235

Imaging – Clinical, Cancer

Title Authors Publication Link
Reproducible Lipid Alterations in Patient-Derived Breast Cancer Xenograft FFPE Tissue Identified with MALDI MSI for Pre-Clinical and Clinical Application V. Denti et al. Metabolites 2021, 11, 9, 577 https://www.mdpi.com/2218-1989/11/9/577
Mass spectrometry imaging of L-[ring-13C6]-labeled phenylalanine and tyrosine kinetics in non-small cell lung carcinoma J. Cao et al. Cancer & Metabolism 2021, 9, 1, 26 https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00262-9
Metabolic tumor constitution is superior to tumor regression grading for evaluating response to neoadjuvant therapy of esophageal adenocarcinoma patients A. Buck et al. The Journal of Pathology, in print https://onlinelibrary.wiley.com/doi/10.1002/path.5828
N-Glycosylation Patterns Correlate with Hepatocellular Carcinoma Genetic Subtypes A. DelaCourt et al. Molecular Cancer Research 2021, 19, 1868-77 https://mcr.aacrjournals.org/content/19/11/1868
Metabolomic therapy response prediction in pretherapeutic tissue biopsies for trastuzumab in patients with HER2‐positive advanced gastric cancer T. Kunzke et al. Clinical and Translational Medicine 2021, 11, 9, e547 https://onlinelibrary.wiley.com/doi/10.1002/ctm2.547
Patterns of carbon-bound exogenous compounds in lung cancer patients and association with disease pathophysiology T. Kunzke et al. Cancer Research 2021, in print https://cancerres.aacrjournals.org/content/81/23/5862
Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence G. Luis et al. Redox Biology 2021, 43, 102006 https://www.sciencedirect.com/science/article/pii/S2213231721001646
Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma V. Panitz et al. Theranostics 2021, 11, 19, 2021, 9217-9233 https://www.thno.org/v11p9217.htm
A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma J. Choi et al. Nature Metabolism 2021, 3, 2, 182-195 https://www.nature.com/articles/s42255-021-00350-6
Imaging Mass Spectrometry and Lectin Analysis of N-Linked Glycans in Carbohydrate Antigen–Defined Pancreatic Cancer Tissues C. T. McDowell et al. Molecular & Cell Proteomics 2021, 20, 100012 https://www.mcponline.org/article/S1535-9476(20)35126-4/fulltext
Spatiotemporal heterogeneity of glioblastoma is dictated by microenvironmental interference V. M. Ravi et al. bioRxiv 2021, pre-print https://www.biorxiv.org/content/10.1101/2021.02.16.431475v1
Slow TCA flux implies low ATP production in tumors C. R. Bartman et al. bioRxiv 2021, pre-print https://www.biorxiv.org/content/10.1101/2021.10.04.463108v1
Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas M. Friedrich et al. Nature Cancer 2021, 2, 7, 723-740 https://www.nature.com/articles/s43018-021-00201-z
Glioblastoma multiforme: Metabolic differences to peritumoral tissue and IDH‐mutated gliomas revealed by mass spectrometry imaging J. M. Kampa et al. Neuropathology 2020, 40, 6, 546-558 https://onlinelibrary.wiley.com/doi/10.1111/neup.12671
Defining the human kidney N-glycome in normal and cancer tissues using MALDI imaging mass spectrometry R. R. Drake et al. Journal of Mass Spectrometry 2020, 55, e4490 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.4490
Extracellular matrix alterations in low‐grade lung adenocarcinoma compared with normal lung tissue by imaging mass spectrometry P. M. Angel et al. Journal of Mass Spectrometry 2020, 55, 4, e4450 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.4450
MALDI-MSI spatially maps N-glycan alterations to histologically distinct pulmonary pathologies following irradiation C. L. Carter et al. Scientific Reports 2020, 10, Article number: 11559 https://www.nature.com/articles/s41598-020-68508-y
Zonal regulation of collagen‐type proteins and posttranslational modifications in prostatic benign and cancer tissues by imaging mass spectrometry P. M. Angel et al. The Prostate 2020, 80, 13, 1071-1086 https://onlinelibrary.wiley.com/doi/10.1002/pros.24031
Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells T. Manzo et al. Journal of Experimental Medicine 2020, 217, 8, e20191920 https://rupress.org/jem/article/217/8/e20191920/151833/Accumulation-of-long-chain-fatty-acids-in-the
Native glycan fragments detected by MALDI-FT-ICR mass spectrometry imaging impact gastric cancer biology and patient outcome T. Kunzke. et al. Oncotarget 2017, 8, 68012-68025 https://www.oncotarget.com/article/19137/text/
Evaluation of Therapeutic Collagen-Based Biomaterials in the Infarcted Mouse Heart by Extracellular Matrix Targeted MALDI Imaging Mass Spectrometry C. L. Clift et al. Journal of The American Society for Mass Spectrometry 2021, 32, 12, 2746–2754 https://pubs.acs.org/doi/10.1021/jasms.1c00189
Lipid signature of advanced human carotid atherosclerosis assessed by mass spectrometry imaging A. M. Moerman et al. The Journal of Lipid Research 2021, 62, 100020 https://www.jlr.org/article/S0022-2275(20)43743-5/fulltext
Spatial N-glycomics of the human aortic valve in development and pediatric endstage congenital aortic valve stenosis P. M. Angel et al. Journal of Molecular and Cellular Cardiology 2021, 154, 6-20 https://www.jmcc-online.com/article/S0022-2828(21)00018-3/fulltext
Imaging Mass Spectrometry Reveals the Changes in the Taurine Conjugates of Dihydroxycholanoic Acid During Hepatic Warm Ischemia and Reperfusion in a Rat Model K. Shibata et al. Transplantation Proceedings 2020, 52, 6, 1880-1883 https://www.sciencedirect.com/science/article/abs/pii/S0041134519317397
Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering C. Härdtner et al. Basic Research in Cardiology 2020, 115, 6, 78 https://link.springer.com/article/10.1007%2Fs00395-020-00838-4
A lipid atlas of human carotid atherosclerosis A. M. Moerman et al. bioRxiv 2020, pre-print https://www.biorxiv.org/content/10.1101/2020.03.09.976043v1

Imaging – Clinical, Cardiovascular

Title Authors Publication Link
Evaluation of Therapeutic Collagen-Based Biomaterials in the Infarcted Mouse Heart by Extracellular Matrix Targeted MALDI Imaging Mass Spectrometry C. L. Clift et al. Journal of The American Society for Mass Spectrometry 2021, 32, 12, 2746–2754 https://pubs.acs.org/doi/10.1021/jasms.1c00189
Lipid signature of advanced human carotid atherosclerosis assessed by mass spectrometry imaging A. M. Moerman et al. The Journal of Lipid Research 2021, 62, 100020 https://www.jlr.org/article/S0022-2275(20)43743-5/fulltext
Spatial N-glycomics of the human aortic valve in development and pediatric endstage congenital aortic valve stenosis P. M. Angel et al. Journal of Molecular and Cellular Cardiology 2021, 154, 6-20 https://www.jmcc-online.com/article/S0022-2828(21)00018-3/fulltext
Imaging Mass Spectrometry Reveals the Changes in the Taurine Conjugates of Dihydroxycholanoic Acid During Hepatic Warm Ischemia and Reperfusion in a Rat Model K. Shibata et al. Transplantation Proceedings 2020, 52, 6, 1880-1883 https://www.sciencedirect.com/science/article/abs/pii/S0041134519317397
Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering C. Härdtner et al. Basic Research in Cardiology 2020, 115, 6, 78 https://link.springer.com/article/10.1007%2Fs00395-020-00838-4
A lipid atlas of human carotid atherosclerosis A. M. Moerman et al. bioRxiv 2020, pre-print https://www.biorxiv.org/content/10.1101/2020.03.09.976043v1

Imaging – Clinical, Neurology

Title Authors Publication Link
Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy H. Hulme et al. Neurobiology of Disease 2020, 137, 104738 https://www.sciencedirect.com/science/article/pii/S0969996120300139
Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA–induced dyskinesia E. Fridjonsdottir et al. Science Advances 2021, 7, 2, eabe5948 https://www.science.org/doi/10.1126/sciadv.abe5948
An imaging mass spectrometry atlas of lipids in the human neurologically normal and Huntington’s disease caudate nucleus M. Hunter et al. Journal of Neurochemistry 2021, 157, 6, 2158-2172 https://onlinelibrary.wiley.com/doi/10.1111/jnc.15325
Metabolomic analysis and mass spectrometry imaging after neonatal stroke and cell therapies in mouse brains E. Tanaka et al. Scientific Reports 2020, 10, 1, 21881 https://www.nature.com/articles/s41598-020-78930-x
µ Opioid Receptor Agonism for L-DOPA-Induced Dyskinesia in Parkinson's Disease E. Bezard et al. Journal of Neuroscience 2020, 40, 35, 6812-6819 https://www.jneurosci.org/content/40/35/6812

Imaging – Clinical, Pathogen

Title Authors Publication Link
Clostridioides difficile infection induces a rapid influx of bile acids into the gut during colonization of the host A. G. Wexler et al. Cell Reports 2021, 36, 10, 109683 https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01130-X
In Vitro Miniaturized Tuberculosis Spheroid Model S. Mukundan et al. Biomedicines 2021, 9, 9, 1209 https://www.mdpi.com/2227-9059/9/9/1209
Identification of Metabolically Quiescent Leishmania mexicana Parasites in Peripheral and Cured Dermal Granulomas Using Stable Isotope Tracing Imaging Mass Spectrometry J. Kloehn et al. mBio 2021, 12, 2, e00129-21 https://journals.asm.org/doi/10.1128/mBio.00129-21
The ascorbate-deficient guinea pig model of shigellosis allows the study of the entire Shigella life cycle A. C. André et al. bioRxiv 2020, pre-print https://www.biorxiv.org/content/10.1101/2020.08.28.270074v1

Imaging – Method Development

Title Authors Publication Link
Streamlined Multimodal DESI and MALDI Mass Spectrometry Imaging on a Singular Dual-Source FT-ICR Mass Spectrometer K. J. Zemaitis et al. Metabolites 2021, 11, 4, 253 https://www.mdpi.com/2218-1989/11/4/253
α‑Cyano-4-hydroxycinnamic Acid and Tri-Potassium Citrate Salt Pre-Coated Silicon Nanopost Array Provides Enhanced Lipid Detection for High Spatial Resolution MALDI Imaging Mass Spectrometry M. Dufresne et al. Analytical Chemistry 2021, 93, 36, 12243-12249 https://pubs.acs.org/doi/10.1021/acs.analchem.1c01560
Automated annotation and visualisation of high-resolution spatial proteomic mass spectrometry imaging data using HIT-MAP G. Guo et al. Nature Communications 2021, 12, 1, 3241 https://www.nature.com/articles/s41467-021-23461-w
Molecular Mapping of Neutral Lipids Using Silicon Nanopost Arrays and TIMS Imaging Mass Spectrometry J. A. Fincher, et al. Journal of The American Society for Mass Spectrometry 2021, 32, 10, 2519-2527 https://pubs.acs.org/doi/10.1021/jasms.1c00159
Adaptive Pixel Mass Recalibration for Mass Spectrometry Imaging Based on Locally Endogenous Biological Signals R. La Rocca, et al. Analytical Chemistry 2021, 93, 8, 4066-4074 https://pubs.acs.org/doi/10.1021/acs.analchem.0c05071
Determination of Abundant Metabolite Matrix Adducts Illuminates the Dark Metabolome of MALDI-Mass Spectrometry Imaging Datasets M. Janda et al. Analytical Chemistry 2021, 93, 24, 8399-8407 https://pubs.acs.org/doi/10.1021/acs.analchem.0c04720
Electroblotting through Enzymatic Membranes to Enhance Molecular Tissue Imaging W. T. Andrews et al. Journal of The American Society for Mass Spectrometry 2021, 32, 7, 1689-1699 https://pubs.acs.org/doi/10.1021/jasms.1c00046
Rapid Automated Annotation and Analysis of N‑Glycan Mass Spectrometry Imaging Data Sets Using NGlycDB in METASPACE D. Veličković et al. Analytical Chemistry 2021, 93, 40, 13421-13425 https://pubs.acs.org/doi/10.1021/acs.analchem.1c02347
Desorption ionization using through‐hole alumina membrane offers higher reproducibility than 2,5‐dihydroxybenzoic acid, a widely used matrix in Fourier transform ion cyclotron resonance mass spectrometry imaging analysis Md. Mahmudul Hasan et al. Rapid Communications in Mass Spectrometry 2021, 35, 10, e9076 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/rcm.9076
On-Slide Heat Sterilization Enables Mass Spectrometry Imaging of Tissue Infected with High-Threat Pathogens Outside of Biocontainment: A Study Directed at Mycobacterium tuberculosis N. Wang et al. Journal of The American Society for Mass Spectrometry 2021, 32, 2664−2674 https://pubs.acs.org/doi/10.1021/jasms.1c00205
Spatial Probabilistic Mapping of Metabolite Ensembles in Mass Spectrometry Imaging D. A. Sammour et al. bioRxiv 2021, preprint https://www.biorxiv.org/content/10.1101/2021.10.27.466114v1
massNet: integrated processing and classification of spatially resolved mass spectrometry data using deep learning for rapid tumor delineation W. M. Abdelmoula et al. bioRxiv 2021, pre-print https://www.biorxiv.org/content/10.1101/2021.05.06.442938v1
High Spatial Resolution MALDI Imaging Mass Spectrometry of Fresh-Frozen Bone C. J. Good et al. bioRxiv 2021, pre-print https://www.biorxiv.org/content/10.1101/2021.10.01.462831v2
Tissue fixation effects on human retinal lipid analysis by MALDI imaging and LC-MS/MS technologies A. Kotnala et al. bioRxiv 2021, pre-print https://www.biorxiv.org/content/10.1101/2021.04.29.442044v2
Spatially aware clustering of ion images in mass spectrometry imaging data using deep learning W. Zhang et al. Analytical and Bioanalytical Chemistry 2021, 413,10, 2803-2819 https://link.springer.com/article/10.1007%2Fs00216-021-03179-w
Dual-polarity SALDI FT-ICR MS imaging and Kendrick mass defect data filtering for lipid analysis W. H. Müller et al. Analytical and Bioanalytical Chemistry 2021, 413, 10, 2821-2830 https://link.springer.com/article/10.1007%2Fs00216-020-03020-w
Identification of Phosphatidylcholine Isomers in Imaging Mass Spectrometry Using Gas-Phase Charge Inversion Ion/Ion Reactions J. T. Specker et al. Analytical Chemistry 2020, 92, 19, 13192-13201 https://pubs.acs.org/doi/10.1021/acs.analchem.0c02350
Bromopyrylium Derivatization Facilitates Identification by Mass Spectrometry Imaging of Monoamine Neurotransmitters and Small Molecule Neuroactive Compounds R. Shariatgorji et al. Journal of The American Society for Mass Spectrometry 2020, 31, 12, 2553-2557 https://pubs.acs.org/doi/10.1021/jasms.0c00166
Multilabel Per-Pixel Quantitation in Mass Spectrometry Imaging F. Dewez et al. Analytical Chemistry 2021, 93, 3, 1393-1400 https://pubs.acs.org/doi/10.1021/acs.analchem.0c03186
Mapping Lipogenic Flux: A Gold LDI–MS Approach for Imaging Neutral Lipid Kinetics D. P. Downes et al. Journal of The American Society for Mass Spectrometry 2020, 31, 12, 2421-2425 https://pubs.acs.org/doi/10.1021/jasms.0c00199
Dynamic Range Expansion by Gas-Phase Ion Fractionation and Enrichment for Imaging Mass Spectrometry B. M. Prentice et al. Analytical Chemistry 2020, 92, 19, 13092-13100 https://pubs.acs.org/doi/10.1021/acs.analchem.0c02121
Multiplexed imaging mass spectrometry of the extracellular matrix using serial enzyme digests from formalin-fixed paraffin-embedded tissue sections C. L. Clift et al. Analytical and Bioanalytical Chemistry 2021, 413, 10, 2709-2719 https://link.springer.com/article/10.1007%2Fs00216-020-03047-z
Discovering New Lipidomic Features Using Cell Type Specific Fluorophore Expression to Provide Spatial and Biological Specificity in a Multimodal Workflow with MALDI Imaging Mass Spectrometry M. A. Jones et al. Analytical Chemistry 2020, 92, 10, 7079-7086 https://pubs.acs.org/doi/10.1021/acs.analchem.0c00446
Uncovering matrix effects on lipid analyses in MALDI imaging mass spectrometry experiments W. J. Perry et al. Journal of Mass Spectrometry 2020, 55, 4, e4491 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.4491
Bringing SEM and MSI Closer Than Ever Before: Visualizing Aspergillus and Pseudomonas Infection in the Rat Lungs T. Juříková et al. Journal of Fungi 2020, 6, 4, 257 https://www.mdpi.com/2309-608X/6/4/257
New Derivatization Reagent for Detection of free Thiol-groups in Metabolites and Proteins in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging A. Fülöp et al. Analytical Chemistry 2020, 92, 9, 6224-6228 https://pubs.acs.org/doi/10.1021/acs.analchem.9b05630
New Enzymatic Approach to Distinguish Fucosylation Isomers of N‑Linked Glycans in Tissues Using MALDI Imaging Mass Spectrometry C. A. West et al. Journal of Proteome Research 2020, 19, 8, 2989-2996 https://pubs.acs.org/doi/10.1021/acs.jproteome.0c00024
Accelerating Fourier Transform-Ion Cyclotron Resonance Mass Spectrometry Imaging Using a Subspace Approach Y. R. Xie et al. Journal of The American Society for Mass Spectrometry 2020, 31, 11, 2338-2347 https://pubs.acs.org/doi/10.1021/jasms.0c00276
De novo discovery of metabolic heterogeneity with immunophenotype-guided imaging mass spectrometry V. M. Prade et al. Molecular Metabolism 2020, 36, 100953 https://www.sciencedirect.com/science/article/pii/S2212877820300259
Metabolomics with 15N Labeling for Characterizing Missing Monoterpene Indole Alkaloids in Plants R. Nakabayashi et al. Analytical Chemistry 2020, 92, 8, 5670-5675 https://pubs.acs.org/doi/10.1021/acs.analchem.9b03860
Combining MALDI mass spectrometry imaging and droplet-base surface sampling analysis for tissue distribution, metabolite profiling, and relative quantification of cyclic peptide melanotan II B. Chen et al. Analytica Chimica Acta 2020, 1125, 279-287 https://www.sciencedirect.com/science/article/abs/pii/S0003267020306024
Cross-validated Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Quantitation Protocol for a Pharmaceutical Drug and Its Drug-Target Effects in the Brain Using Time-of-Flight and Fourier Transform Ion Cyclotron Resonance Analyzers P. Källback et al. Analytical Chemistry 2020, 92, 21, 14676-14684 https://pubs.acs.org/doi/10.1021/acs.analchem.0c03203
Rapid N‑Glycan Profiling of Serum and Plasma by a Novel Slide-Based Imaging Mass Spectrometry Workflow C. R. K. Blaschke et al. Journal of The American Society for Mass Spectrometry 2020, 31, 12, 2511-2520 https://pubs.acs.org/doi/10.1021/jasms.0c00213
Lipid Landscape of the Human Retina and Supporting Tissues Revealed by High-Resolution Imaging Mass Spectrometry D. M. G. Anderson et al. Journal of The American Society for Mass Spectrometry 2020, 31, 12, 2426-2436 https://pubs.acs.org/doi/10.1021/jasms.0c00119
Automating a process convolution approach to account for spatial information in imaging mass spectrometry data C. Miller et al. Spatial Statistics 2020, 36, 100422 https://www.sciencedirect.com/science/article/abs/pii/S2211675320300166
MALDI-MS imaging of lipids in corn using a flexible ultrasonic spraying device as matrix deposition method X. Li et al. International Journal of Mass Spectrometry 2020, 455, 116373 https://www.sciencedirect.com/science/article/abs/pii/S1387380618303816
Structural elucidation of phosphatidylcholines from tissue using electron induced dissociation M. N. Born et al. International Journal of Mass Spectrometry 2020, 452, 116338 https://www.sciencedirect.com/science/article/abs/pii/S1387380619305111
Selective improvement of peptides imaging on tissue by supercritical fluid wash of lipids for matrix-assisted laser desorption/ionization mass spectrometr S. Matsushita et al. Analytical and Bioanalytical Chemistry 2017, 409, 6, 1475–1480 https://link.springer.com/article/10.1007%2Fs00216-016-0119-3
High mass resolution, spatial metabolite mapping enhances the current plant gene and pathway discovery toolbox Y. Dong et al. New Phytologist 2020, 228, 6, 1986-2002 https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.16809

Imaging – Pharmacology/Toxicology

Title Authors Publication Link
Quantitative Mass Spectrometry Imaging to Study Drug Distribution in the Intestine Following Oral Dosing L. R. S. Huizing et al. Analytical Chemistry 2021, 93, 4, 2144-2151 https://pubs.acs.org/doi/10.1021/acs.analchem.0c03956
An optimized method for the detection and spatial distribution of aminoglycoside and vancomycin antibiotics in tissue sections by mass spectrometry imaging N. Wang et al. Journal of Mass Spectrometry 2021, 56, 3, e4708 https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.4708
Distribution of perfluorooctane sulfonate in mice and its effect on liver lipidomic X. Li et al. Talanta 2021, 226, 122150 https://www.sciencedirect.com/science/article/abs/pii/S0039914021000710
An orthogonal methods assessment of topical drug concentrations in skin and the impact for risk assessment in the viable epidermis B. D. Hollingshead et al. Regulatory Toxicology and Pharmacology, 123, 2021, 104934 https://www.sciencedirect.com/science/article/abs/pii/S027323002100074X
Multiorgan Crystal Deposition of an Amphoteric Drug in Rats Due to Lysosomal Accumulation and Conversion to a Poorly Soluble Hydrochloride Salt B. Lenz et al. Toxicological Sciences, 180(2), 2021, 383-394 https://academic.oup.com/toxsci/article/180/2/383/6102740
Study of the Distribution of Acetaminophen and Its Metabolites in Rats, from the Whole-Body to Isolated Organ Levels, by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging after On-Tissue Chemical Derivatization M. Merdas et al. Analytical Chemistry 2021, 93, 39, 13242-13250 https://pubs.acs.org/doi/10.1021/acs.analchem.1c02487
Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood–brain barrier D. Luptáková et al. Molecular Psychiatry 2021, 1-14 https://www.nature.com/articles/s41380-021-01267-y
Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat J. A. Werner et al. Toxicology and Applied Pharmacology 2021, 423, 115578 https://www.sciencedirect.com/science/article/pii/S0041008X2100185X
Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats F. Romero-Palomo et al. Toxicologic Pathology 2021, 49, 6, 1174-1192 https://journals.sagepub.com/doi/10.1177/01926233211011615
Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues A. Balla et al. Pharmaceutics 2021, 13, 5, 658 https://www.mdpi.com/1999-4923/13/5/658
Lesion Penetration and Activity Limit the Utility of Second-Line Injectable Agents in Pulmonary Tuberculosis J. P. Ernest et al. Antimicrobial Agents and Chemotherapy 2021, 65, 10, e00506-21 https://journals.asm.org/doi/10.1128/AAC.00506-21
Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis K. Becker et al. EBioMedicine 2021, 73, 103652 https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00446-1/fulltext
Mass spectrometry imaging reveals lipid upregulation and bile acid changes indicating amitriptyline induced steatosis in a rat model J. M. Kampa et al. Toxicology Letters 2020, 325, 43-50 https://www.sciencedirect.com/science/article/abs/pii/S0378427420300564
Brain distribution of geissoschizine methyl ether in rats using mass spectrometry imaging analysis T. Matsumoto et al. Scientific Reports 2020, 10, 1, 7293 https://www.nature.com/articles/s41598-020-63474-x
Drug Administration Routes Impact the Metabolism of a Synthetic Cannabinoid in the Zebrafish Larvae Model Y. M. Park et al. Molecules 2020, 25, 19, 4474 https://www.mdpi.com/1420-3049/25/19/4474

Imaging – Protocols

Title Authors Publication Link
In Situ Localization of Plant Lipid Metabolites by Matrix-Assisted Laser Desorption/Ionization Mass SpectrometrySpectrometry Imaging (MALDI-MSI) D. Sturtevant et al. Methods in Molecular Biology 2021, Vol. 2295, 417-438 https://link.springer.com/protocol/10.1007%2F978-1-0716-1362-7_24
Multiplexed Imaging Mass Spectrometry of Histological Staining, N-Glycan and Extracellular Matrix from One Tissue Section: A Tool for Fibrosis Research C. L. Clift et al. Methods in Molecular Biology 2021, Vol. 2350, 313-329 https://link.springer.com/protocol/10.1007%2F978-1-0716-1593-5_20
Spatial visualization of comprehensive brain neurotransmitter systems and neuroactive substances by selective in situ chemical derivatization mass spectrometry imaging R. Shariatgorji et al. Nature Protocols 2021, 16, 7, 3298-3321 https://www.nature.com/articles/s41596-021-00538-w
Investigation of Xenobiotics Metabolism In Salix alba Leaves via Mass Spectrometry Imaging. C. Villette et al. Journal of Visualized Experiments 2020, 160, e61011 https://www.jove.com/de/t/61011/investigation-xenobiotics-metabolism-salix-alba-leaves-via-mass

 

For Research Use Only. Not for use in clinical diagnostic procedures.