MRMS Bibliography
Introduction
MRMS Metabolomics and Imaging Bibliography
The MRMS technology is used in Metabolomics to study metabolites in plants, body fluids as well as in bacteria and yeast. MALDI Imaging is a technology that can be perfectly perform with high mass accuracy using the MRMS system. Imaging can be applied to human and animal tissue samples as well as plant samples. An overview of the literature of both technologies is shown here.
Metabolomics
Metabolomics - Plants and Food
| Title | Authors | Publication | Link |
|---|---|---|---|
| Olive Oil Quality and Authenticity Assessment Aspects Employing FIA-MRMS and LC-Orbitrap MS Metabolomic Approaches | T. Nikou et al. | Frontiers in Public Health 2020, Volume 8, Article 558226 | https://www.frontiersin.org/articles/10.3389/fpubh.2020.558226/full |
| Expanding the Scope of Detectable Microbial Natural Products by Complementary Analytical Methods and Cultivation Systems | C. Bader et al. | J. Nat. Prod. 2021, 84, 2, 268–277 | https://pubs.acs.org/doi/10.1021/acs.jnatprod.0c00942 |
| Chemical Fingerprinting of Conifer Needle Essential Oils and Solvent Extracts by Ultrahigh-Resolution Fourier Transform Ion Cyclotron Resonance Mass Spectrometry | O. O. Mofikoya et al. | ACS Omega 2020 5 (18), 10543-10552 | https://pubs.acs.org/doi/10.1021/acsomega.0c00901 |
| Wine aging: a bottleneck story | T. Karbowiak et al. | npj Science of Food 3, 14 (2019) | https://www.nature.com/articles/s41538-019-0045-9 |
| Wine microbiology is driven by vineyard and winery anthropogenic factors | C. Grangeteau et al. | Microbial Biotechnology (2017) 10(2), 354–370 | https://sfamjournals.onlinelibrary.wiley.com/doi/10.1111/1751-7915.12428 |
| The chemodiversity of wines can reveal a metabologeography expression of cooperage oak wood | R. D. Gougeon et al. | PNAS 2009 106 (23) 9174-9179 | https://www.pnas.org/content/106/23/9174 |
| A grape and wine chemodiversity comparison of different appellations in Burgundy: Vintage vs terroir effects | C. Roullier-Gall et al. | Food Chem. 2014, 152, 100-107 | https://www.sciencedirect.com/science/article/abs/pii/S0308814613016907 |
| A Multilevel Study of Melon Fruit Reticulation Provides Insight into Skin Ligno-Suberization Hallmarks | H. Cohen et. al. | Plant Physiology, 179, 4, 2019, 1486–1501 | https://academic.oup.com/plphys/article/179/4/1486/6116732 |
| Revisiting anabasine biosynthesis in tobacco hairy roots expressing plant lysine decarboxylase gene by using 15N-labeled lysine | S. Bunsupa et al. | Plant Biotechnol. 31(5): 511-518 (2014) | https://www.jstage.jst.go.jp/article/plantbiotechnology/31/5/31_14.1008a/_article |
Metabolomics - Plants
| Title | Authors | Publication | Link |
|---|---|---|---|
| Discrimination of Wine Attributes by Metabolome Analysis | A. Cuadros-Inostroza et al. | Anal. Chem. 2010, 82, 9, 3573–3580 | https://pubs.acs.org/doi/10.1021/ac902678t |
| Unraveling different chemical fingerprints between a champagne wine and its aerosols | G. Liger-Belair et al. | PNAS, 2009, 106, 16545–16549 | https://www.pnas.org/content/106/39/16545 |
| The chemodiversity of wines can reveal a metabologeography expression of cooperage oak wood | R. D. Gougeon et al. | PNAS, 2009, 106, 9174–9179 | https://www.pnas.org/content/106/23/9174 |
| Exploring the chemical space of white wine antioxidant capacity: A combined DPPH, EPR and FT-ICR-MS study | R. Romanet et. al. | Food Chem. 355:129566 (2021) | https://www.sciencedirect.com/science/article/abs/pii/S0308814621005720 |
| Hidden in its color: A molecular-level analysis of the beer’s Maillard reaction network | S. Pieczonka et. al. | Food Chem. 361:130112 (2021) | https://www.sciencedirect.com/science/article/abs/pii/S0308814621011183 |
| On the Trail of the German Purity Law: Distinguishing the Metabolic Signatures of Wheat, Corn and Rice in Beer | S. Pieczonka et. al. | Front. Chem. 9:715372 (2021) | https://www.frontiersin.org/articles/10.3389/fchem.2021.715372/full |
| Decomposing the molecular complexity of brewing | S. Pieczonka et. al. | npj Science of Food (2020) 4, 11 | https://www.nature.com/articles/s41538-020-00070-3 |
| Determination of soyasaponins in Fagioli di Sarconi beans (Phaseolus vulgaris L.) by LC-ESI-FTICR-MS and evaluation of their hypoglycemic activity | G. Bianco et al. | Anal. Bioanal. Chem. 410, 1561–1569 (2018) | https://link.springer.com/article/10.1007/s00216-017-0806-8 |
| In situ localization of micropollutants and associated stress response in Populus nigra leaves | C. Vilette et. al. | Environment International 126 (2019) 523–532 | https://www.sciencedirect.com/science/article/pii/S0160412018324917 |
Metabolomics - Body Fluids
| Title | Authors | Publication | Link |
|---|---|---|---|
| Prenatal and Early Postnatal Cerebral d-Aspartate Depletion Influences l-Amino Acid Pathways, Bioenergetic processes, and Developmental Brain Metabolism | M. Grimaldi et al. | J. Proteome Res. 2021, 20, 1, 727–739 | https://pubs.acs.org/doi/10.1021/acs.jproteome.0c00622 |
| Ultrahigh-Resolution Mass Spectrometry-Based Platform for Plasma Metabolomics Applied to Type 2 Diabetes Research | Y. Zhu et al. | J. Proteome Res. 2021 20, 1, 463-473 | https://pubs.acs.org/doi/10.1021/acs.jproteome.0c00510 |
| Metabolomics Reveals Metabolic Biomarkers of Crohn's Disease | J. Jansson et al. | PLOS ONE 2009, 4, e6386 | https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0006386 |
| The compositional space of exhaled breath condensate and its link to the human breath volatilome | F. Moritz et al. | J. Breath Res. 9 027105 (2015) | https://iopscience.iop.org/article/10.1088/1752-7155/9/2/027105 |
| Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD | T. Lee et al. | Gut 2017;66:863–871 | https://gut.bmj.com/content/66/5/863 |
| Dietary fat and gut microbiota interactions determine diet-induced obesity in mice | R. Kübeck et al. | Mol Metab. 2016 Oct 13;5(12):1162-1174 | https://www.sciencedirect.com/science/article/pii/S2212877816301892 |
| Insulin Sensitivity Is Reflected by Characteristic Metabolic Fingerprints - A Fourier Transform Mass Spectrometric Non-Targeted Metabolomics Approach | M. Lucio et al. | PLOS ONE 2010, 5(10): e13317 | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013317 |
Metabolomics – Animals, Yeast and Bacteria
| Title | Authors | Publication | Link |
|---|---|---|---|
| Direct injection Fourier transform ion cyclotron resonance mass spectrometric method for high throughput quantification of quinolones in poultry | L. E. Ikkere, et al. | Journal of Pharmaceutical and Biomedical Analysis 188 (2020) 113389 | https://www.sciencedirect.com/science/article/abs/pii/S0731708520312759 |
| Combination of UHPLC-MS/MS-molecular networking approach and FTICR-MS for the metabolic profiling of Saccharomyces cerevisiae | O. Perruchon et al. | Journal of Pharmaceutical and Biomedical Analysis 195 (2021) 113857 | https://www.sciencedirect.com/science/article/abs/pii/S0731708520317441 |
| Exploring yeast interactions through metabolic profiling | C. Roullier-Gall et al. | Sci Rep 10, 6073 (2020) | https://www.nature.com/articles/s41598-020-63182-6 |
| DI-ICR-FT-MS-based high-throughput deep metabotyping: a case study of the Caenorhabditis elegans–Pseudomonas aeruginosa infection model | M. Witting et al. | Analytical and Bioanalytical Chemistry 407, 1059–1073 (2015) | https://link.springer.com/article/10.1007/s00216-014-8331-5 |
| Marine sequestration of carbon in bacterial metabolites | O. J. Lechtenfeld et al. | Nature Communications 6, 6711 (2015) | https://www.nature.com/articles/ncomms7711 |
| Comprehensive Analysis of the Alternaria Mycobolome Using Mass Spectrometry Based Metabolomics | M. Gotthardt et. al. | Mol. Nutr. Food Res. 2020, 64, 1900558 | https://onlinelibrary.wiley.com/doi/10.1002/mnfr.201900558 |
Metabolomics – Methods
| Title | Authors | Publication | Link |
|---|---|---|---|
| 13C Isotope-Labeled Metabolomes Allowing for Improved Compound Annotation and Relative Quantification in Liquid Chromatography-Mass Spectrometry-based Metabolomic Research | P. Giavalisco et. al. | Anal. Chem. 2009, 81, 15, 6546–6551 | https://pubs.acs.org/doi/10.1021/ac900979e |
| High-Resolution Direct Infusion-Based Mass Spectrometry in Combination with Whole 13C Metabolome Isotope Labeling Allows Unambiguous Assignment of Chemical Sum Formulas | P. Giavalisco et. al. | Anal. Chem. 2008, 80, 24, 9417–9425 | https://pubs.acs.org/doi/10.1021/ac8014627 |
| Potential of dynamically harmonized Fourier transform ion cyclotron resonance cell for high-throughput metabolomics fingerprinting: control of data quality | B. Habchi et al. | Analytical and Bioanalytical Chemistry, 410, 483–490 (2018) | https://link.springer.com/article/10.1007%2Fs00216-017-0738-3 |
| Ultrahigh resolution metabolomics for S-containing metabolites | R. Nakabayashi et. al. | Current Opinion in Biotechnology 2017, 43, 8–16 | https://www.sciencedirect.com/science/article/pii/S0958166916301604 |
| An Enhanced Isotopic Fine Structure Method for Exact Mass Analysis in Discovery Metabolomics: FIA-CASI-FTMS | C. J. Thompson et al. | J. Am. Soc. Mass Spectrom. 2020, 31, 10, 2025–2034 | https://pubs.acs.org/doi/10.1021/jasms.0c00047 |
Imaging
Imaging – General Biology
| Title | Authors | Publication | Link |
|---|---|---|---|
| Lipid Dynamics due to Muscle Atrophy Induced by Immobilization | K. Kimura et al. | Journal of Oleo Science 2021, 70, 7, 937-946 | https://www.jstage.jst.go.jp/article/jos/70/7/70_ess21045/_article |
| Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain | T. Vallianatou et al. | ACS Chemical Neuroscience 2021, 12, 10, 1811-1823 | https://pubs.acs.org/doi/10.1021/acschemneuro.1c00103 |
| Ocular phenotypes in a mouse model of impaired glucocerebrosidase activity | M. Weber et al. | Scientific Reports 2021, 11, 1, 6079 | https://www.nature.com/articles/s41598-021-85528-4 |
| GD3 synthase deletion alters retinal structure and impairs visual function in mice | C. A. Abreu et al. | Journal of Neurochemistry 2021, 158, 3, 694-709 | https://onlinelibrary.wiley.com/doi/10.1111/jnc.15443 |
| Brain glycogen serves as a critical glucosamine cache required for protein glycosylation | R. C. Sun et al. | Cell Metabolism 2021, 33, 7, 1404-1417.e9 | https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00220-5 |
| Multimodal Imaging Mass Spectrometry of Murine Gastrointestinal Tract with Retained Luminal Content Shows Molecular Localization Patterns | E. R. Guiberson et al. | bioRxiv 2021, preprint | https://www.biorxiv.org/content/10.1101/2021.10.03.462819v1 |
| Chelator sensing and lipopeptide interplay mediates molecular interspecies interactions between soil bacilli and pseudomonads | S. Andric et al. | bioRxiv 2021, pre-print | https://www.biorxiv.org/content/10.1101/2021.02.22.432387v2 |
| Mass spectrometry imaging reveals glycine distribution in the developing and adult mouse brain | F. Eto et al. | Journal of Chemical Neuroanatomy 2020, 110, 101869 | https://www.sciencedirect.com/science/article/abs/pii/S0891061820301381 |
| In situ metabolite and lipid analysis of GluN2D−/− and wild-type mice after ischemic stroke using MALDI MSI | W. T. Andrews et al. | Analytical and Bioanalytical Chemistry 2020, 412, 24, 6275-6285 | https://link.springer.com/article/10.1007%2Fs00216-020-02477-z |
| In situ detection and imaging of lysophospholipids in zebrafish using matrix‐assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry | K. He et al. | Journal of Mass Spectrometry 2021, 56, 4, e4637 | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.4637 |
| Spatial Localization of Vitamin D Metabolites in Mouse Kidney by Mass Spectrometry Imaging | K. W. Smith et al. | ACS Omega 2020, 5, 22, 13430-13437 | https://pubs.acs.org/doi/10.1021/acsomega.0c01697 |
| Mass spectrometry imaging reveals differential localization of natural sunscreens in the mantle of the giant clam Tridacna crocea | M. Goto-Inoue et al. | Scientific Reports 2020, 10, 1, 656 | https://www.nature.com/articles/s41598-019-57296-9 |
| Localization of the lens intermediate filament switch by imaging mass spectrometry | Z. Wang et al. | Experimental Eye Research 2020, 198, 108134 | https://www.sciencedirect.com/science/article/abs/pii/S0014483520303924 |
| Region-specific effects of Scrapper on the abundance of glutamate and gamma-aminobutyric acid in the mouse brain | F. Eto et al. | Scientific Reports 2020, 10, 1, 7435 | https://www.nature.com/articles/s41598-020-64277-w |
| Mapping glucose metabolites in the normal bovine lens: Evaluation and optimisation of a matrix‐assisted laser desorption/ionisation imaging mass spectrometry method | A. Zahraei et al. | Journal of Mass Spectrometry 2021, 56, 4, e4666 | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.4666 |
| Spatial segmentation and metabolite annotation involved in sperm maturation in the rat epididymis by MALDI Imaging mass spectrometry | M. Lagarrigue et al. | Journal of Mass Spectrometry 2020, 55, 12, e4633 | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jms.4633 |
| Imaging mass spectrometry to visualise increased acetylcholine in lungs of asthma model mice | T. Matsuda et al. | Analytical and Bioanalytical Chemistry 2020, 412, 18, 4327-4341 | https://link.springer.com/article/10.1007%2Fs00216-020-02670-0 |
| A micrometer‐scale snapshot on phototroph spatial distributions: mass spectrometry imaging of microbial mats in Octopus Spring, Yellowstone National Park | L. Wörmer et al. | Geobiology 2020, 18, 6, 742-759 | https://onlinelibrary.wiley.com/doi/10.1111/gbi.12411 |
| PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle | H. Yoon et al. | Cell Metabolism 2020, 32, 2, 215-228.e7 | https://www.cell.com/cell-metabolism/fulltext/S1550-4131(20)30318-1 |
| A Global Cndp1-Knock-Out Selectively Increases Renal Carnosine and Anserine Concentrations in an Age- and Gender-Specific Manner in Mice | T. Weigand et al. | International Journal of Molecular Sciences 2020, 21, 14, 4887 | https://www.mdpi.com/1422-0067/21/14/4887 |
| Nonclinical applications of quantitative whole-body autoradiography, and imaging mass spectrometry in drug discovery and development | E. G. Solon et al. | Progress in Biomedical Optics and Imaging 2020, Vol. 11219, 1121903-1121903-13 | https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11219/2551441/Nonclinical-applications-of-quantitative-whole-body-autoradiography-and-imaging-mass/10.1117/12.2551441.short |
| Epilipidomics of Senescent Dermal Fibroblasts Identify Lysophosphatidylcholines as Pleiotropic Senescence-Associated Secretory Phenotype (SASP) Factors | M. Narzt et al. | Journal of Investigative Dermatology 2020, 141, 4, 993-1006.e15 | https://www.jidonline.org/article/S0022-202X(20)32367-8/fulltext |
| Mass spectrometry imaging of blast overpressure induced modulation of GABA/glutamate levels in the central auditory neuraxis of Chinchilla | K. Zemaitis et al. | Experimental and Molecular Pathology 2021, 119, 104605 | https://www.sciencedirect.com/science/article/abs/pii/S0014480021000046 |
Imaging – Plant Biology
| Title | Authors | Publication | Link |
|---|---|---|---|
| Unveiling spatial metabolome of Paeonia suffruticosa and Paeonia lactiflora roots using MALDI MS imaging | B. Li et al. | New Phytologist 2021, 231, 2, 892-902 | https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.17393 |
| Analysis of Erythroxylum coca Leaves by Imaging Mass Spectrometry (MALDI–FT–ICR IMS) | N. A. dos Santos et al. | Journal of The American Society for Mass Spectrometry 2021, 32, 4, 946-955 | https://pubs.acs.org/doi/10.1021/jasms.0c00449 |
| Sclareol and linalyl acetate are produced by glandular trichomes through the MEP pathway | C. Chalvin et al. | Horticulture Research 2021, 8, 1, 206 | https://www.nature.com/articles/s41438-021-00640-w |
| High spatial resolution imaging of the dynamics of cuticular lipid deposition during Arabidopsis flower development | L. E. Alexander | Plant Direct 2021, 5, 4, e00322 | https://onlinelibrary.wiley.com/doi/10.1002/pld3.322 |
| The metabolic environment of the developing embryo: A multidisciplinary approach on oilseed rapeseed | H. Rolletschek et al. | Journal of Plant Physiology 2021, 265, 153505 | https://www.sciencedirect.com/science/article/pii/S0176161721001449 |
| The GORKY glycoalkaloid transporter is indispensable for preventing tomato bitterness | Y. Kazachkova et al. | Nature Plants 2021, 7, 4, 468-480 | https://www.nature.com/articles/s41477-021-00865-6 |
| Spatial metabolomics using imaging mass spectrometry to identify the localization of asparaptine A in Asparagus officinalis | R. Nakabayashi et al. | Plant Biotechnology 2021, 38, 3, 311-315 | https://www.jstage.jst.go.jp/article/plantbiotechnology/38/3/38_21.0504b/_article |
| A multimodal metabolomics approach using imaging mass spectrometry and liquid chromatography-tandem mass spectrometry for spatially characterizing monoterpene indole alkaloids secreted from roots | R. Nakabayashi et al. | Plant Biotechnology 2021, 38, 3, 305-310 | https://www.jstage.jst.go.jp/article/plantbiotechnology/38/3/38_21.0504a/_article |
| Preserved and variable spatial‐chemical changes of lipids across tomato leaves in response to central vein wounding reveals potential origin of linolenic acid in signal transduction cascade | D. Veličković, et al. | Plant-Environment Interactions 2021, 2, 1, 28-35 | https://onlinelibrary.wiley.com/doi/10.1002/pei3.10038 |
| Maize Zmcyp710a8 Mutant as a Tool to Decipher the Function of Stigmasterol in Plant Metabolism | S. I. Aboobucker et al. | Frontiers in Plant Science 2021, 12, 732216 | https://www.frontiersin.org/articles/10.3389/fpls.2021.732216/full |
| Localization of mercury and gold in cassava (Manihot esculenta Crantz) | H. J. P. Alcantara et al. | Environmental Science and Pollution Research 2020, 27, 15, 18498-18509 | https://link.springer.com/article/10.1007%2Fs11356-020-08285-3 |
| Unique and highly specific cyanogenic glycoside localisation in stigmatic cells and pollen in the genus Lomatia (Proteaceae) | E. Ritmejerytė et al. | Annals of Botany 2020, 126, 3, 387-400 | https://academic.oup.com/aob/article/126/3/387/5802779 |
| An approach for broad molecular imaging of the root-soil interface via indirect matrix-assisted laser desorption/ionization mass spectrometry | D. Veličković et al. | Soil Biology and Biochemistry 2020, 146, 107804 | https://www.sciencedirect.com/science/article/abs/pii/S0038071720301012 |
| Chemical characterization, antioxidant and antimicrobial activities of açaí seed (Euterpe oleracea Mart.) extracts containing A- and B-type procyanidins | G. R. Martins et al. | LWT 2020, 132, 109830 | https://www.sciencedirect.com/science/article/abs/pii/S0023643820308197 |
| Differential distribution of characteristic constituents in root, stem and leaf tissues of Salvia miltiorrhiza using MALDI mass spectrometry imaging | S. Li et al. | Fitoterapia 2020, 146, 104679 | https://www.sciencedirect.com/science/article/abs/pii/S0367326X20302616 |
| Rhizosphere microbiome mediates systemic root metabolite exudation by root-to-root signaling | E. Korenblum et al. | Proceedings of the National Academy of Sciences of the United States of America 2020, 117, 7, 3874-3883 | https://www.pnas.org/content/117/7/3874 |
| Metabolomics should be deployed in the identification and characterization of gene‐edited crops | P. D. Fraser et al. | The Plant Journal 2020, 102, 5, 897-902 | https://onlinelibrary.wiley.com/doi/10.1111/tpj.14679 |
Imaging – Other Applications
| Title | Authors | Publication | Link |
|---|---|---|---|
| Secret messaging with endogenous chemistry | E. Kennedy et al. | Scientific Reports 2021, 11, 1, 13960 | https://www.nature.com/articles/s41598-021-92987-2 |
| Mechanistic Insights Into Molecular Proxies Through Comparison of Subannually Resolved Sedimentary Records With Instrumental Water Column Data in the Santa Barbara Basin, Southern California | S. Alfken et al. | Paleoceanography and Paleoclimatology 2020, 35, 10, e2020PA004076 | https://agupubs.onlinelibrary.wiley.com/doi/10.1029/2020PA004076 |
| An annually resolved record of Western European vegetation response to Younger Dryas cooling | I. Obreht et al. | Quaternary Science Reviews 2020, 231, 106198 | https://www.sciencedirect.com/science/article/pii/S0277379119311485 |
| Moxidectin toxicity to zebrafish embryos: Bioaccumulation and biomarker responses | M. S. Muniz et al. | Environmental Pollution 2021, 283, 117096 | https://www.sciencedirect.com/science/article/abs/pii/S0269749121006783 |
Imaging – Clinical, Other Applications
| Title | Authors | Publication | Link |
|---|---|---|---|
| MALDI Mass Spectrometry Imaging in a Primary Demyelination Model of Murine Spinal Cord | E. R. Sekera et al. | Journal of The American Society for Mass Spectrometry 2020, 31, 12, 2462-2468 | https://pubs.acs.org/doi/10.1021/jasms.0c00187 |
| Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice | A. Aliluev et al. | Nature Metabolism 2021, 3, 9, 1202-1216 | https://www.nature.com/articles/s42255-021-00458-9 |
| Targeted Expression of TGFBIp Peptides in Mouse and Human Tissue by MALDI-Mass Spectrometry Imaging | V. Anandalakshmi et al. | Separations 2021, 8, 7, 97 | https://www.mdpi.com/2297-8739/8/7/97 |
| Identification of a distinct lipidomic profile in the osteoarthritic synovial membrane by mass spectrometry imaging | B. Rocha et al. | Osteoarthritis and Cartilage 2021, 29, 5, 750-761 | https://www.oarsijournal.com/article/S1063-4584(21)00038-8/fulltext |
| Muscle metabolic remodelling patterns in Duchenne muscular dystrophy revealed by ultra-high-resolution mass spectrometry imaging | I. Dabaj et al. | Scientific Reports 2021, 11, 1, 1906 | https://www.nature.com/articles/s41598-021-81090-1 |
| Integrative Metabolic Pathway Analysis Reveals Novel Therapeutic Targets in Osteoarthritis | B. Rocha et al. | Molecular & Cellular Proteomics 2020, 19, 4, 574-588 | https://www.mcponline.org/article/S1535-9476(20)35018-0/fulltext |
| Maternal obesity alters placental lysophosphatidylcholines, lipid storage, and the expression of genes associated with lipid metabolism | K. L. Bidne et al. | Biology of Reproduction 2021, 104, 1, 197-210 | https://academic.oup.com/biolreprod/article/104/1/197/5922235 |
Imaging – Clinical, Cancer
| Title | Authors | Publication | Link |
|---|---|---|---|
| Reproducible Lipid Alterations in Patient-Derived Breast Cancer Xenograft FFPE Tissue Identified with MALDI MSI for Pre-Clinical and Clinical Application | V. Denti et al. | Metabolites 2021, 11, 9, 577 | https://www.mdpi.com/2218-1989/11/9/577 |
| Mass spectrometry imaging of L-[ring-13C6]-labeled phenylalanine and tyrosine kinetics in non-small cell lung carcinoma | J. Cao et al. | Cancer & Metabolism 2021, 9, 1, 26 | https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00262-9 |
| Metabolic tumor constitution is superior to tumor regression grading for evaluating response to neoadjuvant therapy of esophageal adenocarcinoma patients | A. Buck et al. | The Journal of Pathology, in print | https://onlinelibrary.wiley.com/doi/10.1002/path.5828 |
| N-Glycosylation Patterns Correlate with Hepatocellular Carcinoma Genetic Subtypes | A. DelaCourt et al. | Molecular Cancer Research 2021, 19, 1868-77 | https://mcr.aacrjournals.org/content/19/11/1868 |
| Metabolomic therapy response prediction in pretherapeutic tissue biopsies for trastuzumab in patients with HER2‐positive advanced gastric cancer | T. Kunzke et al. | Clinical and Translational Medicine 2021, 11, 9, e547 | https://onlinelibrary.wiley.com/doi/10.1002/ctm2.547 |
| Patterns of carbon-bound exogenous compounds in lung cancer patients and association with disease pathophysiology | T. Kunzke et al. | Cancer Research 2021, in print | https://cancerres.aacrjournals.org/content/81/23/5862 |
| Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence | G. Luis et al. | Redox Biology 2021, 43, 102006 | https://www.sciencedirect.com/science/article/pii/S2213231721001646 |
| Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma | V. Panitz et al. | Theranostics 2021, 11, 19, 2021, 9217-9233 | https://www.thno.org/v11p9217.htm |
| A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma | J. Choi et al. | Nature Metabolism 2021, 3, 2, 182-195 | https://www.nature.com/articles/s42255-021-00350-6 |
| Imaging Mass Spectrometry and Lectin Analysis of N-Linked Glycans in Carbohydrate Antigen–Defined Pancreatic Cancer Tissues | C. T. McDowell et al. | Molecular & Cell Proteomics 2021, 20, 100012 | https://www.mcponline.org/article/S1535-9476(20)35126-4/fulltext |
| Spatiotemporal heterogeneity of glioblastoma is dictated by microenvironmental interference | V. M. Ravi et al. | bioRxiv 2021, pre-print | https://www.biorxiv.org/content/10.1101/2021.02.16.431475v1 |
| Slow TCA flux implies low ATP production in tumors | C. R. Bartman et al. | bioRxiv 2021, pre-print | https://www.biorxiv.org/content/10.1101/2021.10.04.463108v1 |
| Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas | M. Friedrich et al. | Nature Cancer 2021, 2, 7, 723-740 | https://www.nature.com/articles/s43018-021-00201-z |
| Glioblastoma multiforme: Metabolic differences to peritumoral tissue and IDH‐mutated gliomas revealed by mass spectrometry imaging | J. M. Kampa et al. | Neuropathology 2020, 40, 6, 546-558 | https://onlinelibrary.wiley.com/doi/10.1111/neup.12671 |
| Defining the human kidney N-glycome in normal and cancer tissues using MALDI imaging mass spectrometry | R. R. Drake et al. | Journal of Mass Spectrometry 2020, 55, e4490 | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.4490 |
| Extracellular matrix alterations in low‐grade lung adenocarcinoma compared with normal lung tissue by imaging mass spectrometry | P. M. Angel et al. | Journal of Mass Spectrometry 2020, 55, 4, e4450 | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.4450 |
| MALDI-MSI spatially maps N-glycan alterations to histologically distinct pulmonary pathologies following irradiation | C. L. Carter et al. | Scientific Reports 2020, 10, Article number: 11559 | https://www.nature.com/articles/s41598-020-68508-y |
| Zonal regulation of collagen‐type proteins and posttranslational modifications in prostatic benign and cancer tissues by imaging mass spectrometry | P. M. Angel et al. | The Prostate 2020, 80, 13, 1071-1086 | https://onlinelibrary.wiley.com/doi/10.1002/pros.24031 |
| Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells | T. Manzo et al. | Journal of Experimental Medicine 2020, 217, 8, e20191920 | https://rupress.org/jem/article/217/8/e20191920/151833/Accumulation-of-long-chain-fatty-acids-in-the |
| Native glycan fragments detected by MALDI-FT-ICR mass spectrometry imaging impact gastric cancer biology and patient outcome | T. Kunzke. et al. | Oncotarget 2017, 8, 68012-68025 | https://www.oncotarget.com/article/19137/text/ |
| Evaluation of Therapeutic Collagen-Based Biomaterials in the Infarcted Mouse Heart by Extracellular Matrix Targeted MALDI Imaging Mass Spectrometry | C. L. Clift et al. | Journal of The American Society for Mass Spectrometry 2021, 32, 12, 2746–2754 | https://pubs.acs.org/doi/10.1021/jasms.1c00189 |
| Lipid signature of advanced human carotid atherosclerosis assessed by mass spectrometry imaging | A. M. Moerman et al. | The Journal of Lipid Research 2021, 62, 100020 | https://www.jlr.org/article/S0022-2275(20)43743-5/fulltext |
| Spatial N-glycomics of the human aortic valve in development and pediatric endstage congenital aortic valve stenosis | P. M. Angel et al. | Journal of Molecular and Cellular Cardiology 2021, 154, 6-20 | https://www.jmcc-online.com/article/S0022-2828(21)00018-3/fulltext |
| Imaging Mass Spectrometry Reveals the Changes in the Taurine Conjugates of Dihydroxycholanoic Acid During Hepatic Warm Ischemia and Reperfusion in a Rat Model | K. Shibata et al. | Transplantation Proceedings 2020, 52, 6, 1880-1883 | https://www.sciencedirect.com/science/article/abs/pii/S0041134519317397 |
| Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering | C. Härdtner et al. | Basic Research in Cardiology 2020, 115, 6, 78 | https://link.springer.com/article/10.1007%2Fs00395-020-00838-4 |
| A lipid atlas of human carotid atherosclerosis | A. M. Moerman et al. | bioRxiv 2020, pre-print | https://www.biorxiv.org/content/10.1101/2020.03.09.976043v1 |
Imaging – Clinical, Cardiovascular
| Title | Authors | Publication | Link |
|---|---|---|---|
| Evaluation of Therapeutic Collagen-Based Biomaterials in the Infarcted Mouse Heart by Extracellular Matrix Targeted MALDI Imaging Mass Spectrometry | C. L. Clift et al. | Journal of The American Society for Mass Spectrometry 2021, 32, 12, 2746–2754 | https://pubs.acs.org/doi/10.1021/jasms.1c00189 |
| Lipid signature of advanced human carotid atherosclerosis assessed by mass spectrometry imaging | A. M. Moerman et al. | The Journal of Lipid Research 2021, 62, 100020 | https://www.jlr.org/article/S0022-2275(20)43743-5/fulltext |
| Spatial N-glycomics of the human aortic valve in development and pediatric endstage congenital aortic valve stenosis | P. M. Angel et al. | Journal of Molecular and Cellular Cardiology 2021, 154, 6-20 | https://www.jmcc-online.com/article/S0022-2828(21)00018-3/fulltext |
| Imaging Mass Spectrometry Reveals the Changes in the Taurine Conjugates of Dihydroxycholanoic Acid During Hepatic Warm Ischemia and Reperfusion in a Rat Model | K. Shibata et al. | Transplantation Proceedings 2020, 52, 6, 1880-1883 | https://www.sciencedirect.com/science/article/abs/pii/S0041134519317397 |
| Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering | C. Härdtner et al. | Basic Research in Cardiology 2020, 115, 6, 78 | https://link.springer.com/article/10.1007%2Fs00395-020-00838-4 |
| A lipid atlas of human carotid atherosclerosis | A. M. Moerman et al. | bioRxiv 2020, pre-print | https://www.biorxiv.org/content/10.1101/2020.03.09.976043v1 |
Imaging – Clinical, Neurology
| Title | Authors | Publication | Link |
|---|---|---|---|
| Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy | H. Hulme et al. | Neurobiology of Disease 2020, 137, 104738 | https://www.sciencedirect.com/science/article/pii/S0969996120300139 |
| Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA–induced dyskinesia | E. Fridjonsdottir et al. | Science Advances 2021, 7, 2, eabe5948 | https://www.science.org/doi/10.1126/sciadv.abe5948 |
| An imaging mass spectrometry atlas of lipids in the human neurologically normal and Huntington’s disease caudate nucleus | M. Hunter et al. | Journal of Neurochemistry 2021, 157, 6, 2158-2172 | https://onlinelibrary.wiley.com/doi/10.1111/jnc.15325 |
| Metabolomic analysis and mass spectrometry imaging after neonatal stroke and cell therapies in mouse brains | E. Tanaka et al. | Scientific Reports 2020, 10, 1, 21881 | https://www.nature.com/articles/s41598-020-78930-x |
| µ Opioid Receptor Agonism for L-DOPA-Induced Dyskinesia in Parkinson's Disease | E. Bezard et al. | Journal of Neuroscience 2020, 40, 35, 6812-6819 | https://www.jneurosci.org/content/40/35/6812 |
Imaging – Clinical, Pathogen
| Title | Authors | Publication | Link |
|---|---|---|---|
| Clostridioides difficile infection induces a rapid influx of bile acids into the gut during colonization of the host | A. G. Wexler et al. | Cell Reports 2021, 36, 10, 109683 | https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01130-X |
| In Vitro Miniaturized Tuberculosis Spheroid Model | S. Mukundan et al. | Biomedicines 2021, 9, 9, 1209 | https://www.mdpi.com/2227-9059/9/9/1209 |
| Identification of Metabolically Quiescent Leishmania mexicana Parasites in Peripheral and Cured Dermal Granulomas Using Stable Isotope Tracing Imaging Mass Spectrometry | J. Kloehn et al. | mBio 2021, 12, 2, e00129-21 | https://journals.asm.org/doi/10.1128/mBio.00129-21 |
| The ascorbate-deficient guinea pig model of shigellosis allows the study of the entire Shigella life cycle | A. C. André et al. | bioRxiv 2020, pre-print | https://www.biorxiv.org/content/10.1101/2020.08.28.270074v1 |
Imaging – Method Development
| Title | Authors | Publication | Link |
|---|---|---|---|
| Streamlined Multimodal DESI and MALDI Mass Spectrometry Imaging on a Singular Dual-Source FT-ICR Mass Spectrometer | K. J. Zemaitis et al. | Metabolites 2021, 11, 4, 253 | https://www.mdpi.com/2218-1989/11/4/253 |
| α‑Cyano-4-hydroxycinnamic Acid and Tri-Potassium Citrate Salt Pre-Coated Silicon Nanopost Array Provides Enhanced Lipid Detection for High Spatial Resolution MALDI Imaging Mass Spectrometry | M. Dufresne et al. | Analytical Chemistry 2021, 93, 36, 12243-12249 | https://pubs.acs.org/doi/10.1021/acs.analchem.1c01560 |
| Automated annotation and visualisation of high-resolution spatial proteomic mass spectrometry imaging data using HIT-MAP | G. Guo et al. | Nature Communications 2021, 12, 1, 3241 | https://www.nature.com/articles/s41467-021-23461-w |
| Molecular Mapping of Neutral Lipids Using Silicon Nanopost Arrays and TIMS Imaging Mass Spectrometry | J. A. Fincher, et al. | Journal of The American Society for Mass Spectrometry 2021, 32, 10, 2519-2527 | https://pubs.acs.org/doi/10.1021/jasms.1c00159 |
| Adaptive Pixel Mass Recalibration for Mass Spectrometry Imaging Based on Locally Endogenous Biological Signals | R. La Rocca, et al. | Analytical Chemistry 2021, 93, 8, 4066-4074 | https://pubs.acs.org/doi/10.1021/acs.analchem.0c05071 |
| Determination of Abundant Metabolite Matrix Adducts Illuminates the Dark Metabolome of MALDI-Mass Spectrometry Imaging Datasets | M. Janda et al. | Analytical Chemistry 2021, 93, 24, 8399-8407 | https://pubs.acs.org/doi/10.1021/acs.analchem.0c04720 |
| Electroblotting through Enzymatic Membranes to Enhance Molecular Tissue Imaging | W. T. Andrews et al. | Journal of The American Society for Mass Spectrometry 2021, 32, 7, 1689-1699 | https://pubs.acs.org/doi/10.1021/jasms.1c00046 |
| Rapid Automated Annotation and Analysis of N‑Glycan Mass Spectrometry Imaging Data Sets Using NGlycDB in METASPACE | D. Veličković et al. | Analytical Chemistry 2021, 93, 40, 13421-13425 | https://pubs.acs.org/doi/10.1021/acs.analchem.1c02347 |
| Desorption ionization using through‐hole alumina membrane offers higher reproducibility than 2,5‐dihydroxybenzoic acid, a widely used matrix in Fourier transform ion cyclotron resonance mass spectrometry imaging analysis | Md. Mahmudul Hasan et al. | Rapid Communications in Mass Spectrometry 2021, 35, 10, e9076 | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/rcm.9076 |
| On-Slide Heat Sterilization Enables Mass Spectrometry Imaging of Tissue Infected with High-Threat Pathogens Outside of Biocontainment: A Study Directed at Mycobacterium tuberculosis | N. Wang et al. | Journal of The American Society for Mass Spectrometry 2021, 32, 2664−2674 | https://pubs.acs.org/doi/10.1021/jasms.1c00205 |
| Spatial Probabilistic Mapping of Metabolite Ensembles in Mass Spectrometry Imaging | D. A. Sammour et al. | bioRxiv 2021, preprint | https://www.biorxiv.org/content/10.1101/2021.10.27.466114v1 |
| massNet: integrated processing and classification of spatially resolved mass spectrometry data using deep learning for rapid tumor delineation | W. M. Abdelmoula et al. | bioRxiv 2021, pre-print | https://www.biorxiv.org/content/10.1101/2021.05.06.442938v1 |
| High Spatial Resolution MALDI Imaging Mass Spectrometry of Fresh-Frozen Bone | C. J. Good et al. | bioRxiv 2021, pre-print | https://www.biorxiv.org/content/10.1101/2021.10.01.462831v2 |
| Tissue fixation effects on human retinal lipid analysis by MALDI imaging and LC-MS/MS technologies | A. Kotnala et al. | bioRxiv 2021, pre-print | https://www.biorxiv.org/content/10.1101/2021.04.29.442044v2 |
| Spatially aware clustering of ion images in mass spectrometry imaging data using deep learning | W. Zhang et al. | Analytical and Bioanalytical Chemistry 2021, 413,10, 2803-2819 | https://link.springer.com/article/10.1007%2Fs00216-021-03179-w |
| Dual-polarity SALDI FT-ICR MS imaging and Kendrick mass defect data filtering for lipid analysis | W. H. Müller et al. | Analytical and Bioanalytical Chemistry 2021, 413, 10, 2821-2830 | https://link.springer.com/article/10.1007%2Fs00216-020-03020-w |
| Identification of Phosphatidylcholine Isomers in Imaging Mass Spectrometry Using Gas-Phase Charge Inversion Ion/Ion Reactions | J. T. Specker et al. | Analytical Chemistry 2020, 92, 19, 13192-13201 | https://pubs.acs.org/doi/10.1021/acs.analchem.0c02350 |
| Bromopyrylium Derivatization Facilitates Identification by Mass Spectrometry Imaging of Monoamine Neurotransmitters and Small Molecule Neuroactive Compounds | R. Shariatgorji et al. | Journal of The American Society for Mass Spectrometry 2020, 31, 12, 2553-2557 | https://pubs.acs.org/doi/10.1021/jasms.0c00166 |
| Multilabel Per-Pixel Quantitation in Mass Spectrometry Imaging | F. Dewez et al. | Analytical Chemistry 2021, 93, 3, 1393-1400 | https://pubs.acs.org/doi/10.1021/acs.analchem.0c03186 |
| Mapping Lipogenic Flux: A Gold LDI–MS Approach for Imaging Neutral Lipid Kinetics | D. P. Downes et al. | Journal of The American Society for Mass Spectrometry 2020, 31, 12, 2421-2425 | https://pubs.acs.org/doi/10.1021/jasms.0c00199 |
| Dynamic Range Expansion by Gas-Phase Ion Fractionation and Enrichment for Imaging Mass Spectrometry | B. M. Prentice et al. | Analytical Chemistry 2020, 92, 19, 13092-13100 | https://pubs.acs.org/doi/10.1021/acs.analchem.0c02121 |
| Multiplexed imaging mass spectrometry of the extracellular matrix using serial enzyme digests from formalin-fixed paraffin-embedded tissue sections | C. L. Clift et al. | Analytical and Bioanalytical Chemistry 2021, 413, 10, 2709-2719 | https://link.springer.com/article/10.1007%2Fs00216-020-03047-z |
| Discovering New Lipidomic Features Using Cell Type Specific Fluorophore Expression to Provide Spatial and Biological Specificity in a Multimodal Workflow with MALDI Imaging Mass Spectrometry | M. A. Jones et al. | Analytical Chemistry 2020, 92, 10, 7079-7086 | https://pubs.acs.org/doi/10.1021/acs.analchem.0c00446 |
| Uncovering matrix effects on lipid analyses in MALDI imaging mass spectrometry experiments | W. J. Perry et al. | Journal of Mass Spectrometry 2020, 55, 4, e4491 | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.4491 |
| Bringing SEM and MSI Closer Than Ever Before: Visualizing Aspergillus and Pseudomonas Infection in the Rat Lungs | T. Juříková et al. | Journal of Fungi 2020, 6, 4, 257 | https://www.mdpi.com/2309-608X/6/4/257 |
| New Derivatization Reagent for Detection of free Thiol-groups in Metabolites and Proteins in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging | A. Fülöp et al. | Analytical Chemistry 2020, 92, 9, 6224-6228 | https://pubs.acs.org/doi/10.1021/acs.analchem.9b05630 |
| New Enzymatic Approach to Distinguish Fucosylation Isomers of N‑Linked Glycans in Tissues Using MALDI Imaging Mass Spectrometry | C. A. West et al. | Journal of Proteome Research 2020, 19, 8, 2989-2996 | https://pubs.acs.org/doi/10.1021/acs.jproteome.0c00024 |
| Accelerating Fourier Transform-Ion Cyclotron Resonance Mass Spectrometry Imaging Using a Subspace Approach | Y. R. Xie et al. | Journal of The American Society for Mass Spectrometry 2020, 31, 11, 2338-2347 | https://pubs.acs.org/doi/10.1021/jasms.0c00276 |
| De novo discovery of metabolic heterogeneity with immunophenotype-guided imaging mass spectrometry | V. M. Prade et al. | Molecular Metabolism 2020, 36, 100953 | https://www.sciencedirect.com/science/article/pii/S2212877820300259 |
| Metabolomics with 15N Labeling for Characterizing Missing Monoterpene Indole Alkaloids in Plants | R. Nakabayashi et al. | Analytical Chemistry 2020, 92, 8, 5670-5675 | https://pubs.acs.org/doi/10.1021/acs.analchem.9b03860 |
| Combining MALDI mass spectrometry imaging and droplet-base surface sampling analysis for tissue distribution, metabolite profiling, and relative quantification of cyclic peptide melanotan II | B. Chen et al. | Analytica Chimica Acta 2020, 1125, 279-287 | https://www.sciencedirect.com/science/article/abs/pii/S0003267020306024 |
| Cross-validated Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Quantitation Protocol for a Pharmaceutical Drug and Its Drug-Target Effects in the Brain Using Time-of-Flight and Fourier Transform Ion Cyclotron Resonance Analyzers | P. Källback et al. | Analytical Chemistry 2020, 92, 21, 14676-14684 | https://pubs.acs.org/doi/10.1021/acs.analchem.0c03203 |
| Rapid N‑Glycan Profiling of Serum and Plasma by a Novel Slide-Based Imaging Mass Spectrometry Workflow | C. R. K. Blaschke et al. | Journal of The American Society for Mass Spectrometry 2020, 31, 12, 2511-2520 | https://pubs.acs.org/doi/10.1021/jasms.0c00213 |
| Lipid Landscape of the Human Retina and Supporting Tissues Revealed by High-Resolution Imaging Mass Spectrometry | D. M. G. Anderson et al. | Journal of The American Society for Mass Spectrometry 2020, 31, 12, 2426-2436 | https://pubs.acs.org/doi/10.1021/jasms.0c00119 |
| Automating a process convolution approach to account for spatial information in imaging mass spectrometry data | C. Miller et al. | Spatial Statistics 2020, 36, 100422 | https://www.sciencedirect.com/science/article/abs/pii/S2211675320300166 |
| MALDI-MS imaging of lipids in corn using a flexible ultrasonic spraying device as matrix deposition method | X. Li et al. | International Journal of Mass Spectrometry 2020, 455, 116373 | https://www.sciencedirect.com/science/article/abs/pii/S1387380618303816 |
| Structural elucidation of phosphatidylcholines from tissue using electron induced dissociation | M. N. Born et al. | International Journal of Mass Spectrometry 2020, 452, 116338 | https://www.sciencedirect.com/science/article/abs/pii/S1387380619305111 |
| Selective improvement of peptides imaging on tissue by supercritical fluid wash of lipids for matrix-assisted laser desorption/ionization mass spectrometr | S. Matsushita et al. | Analytical and Bioanalytical Chemistry 2017, 409, 6, 1475–1480 | https://link.springer.com/article/10.1007%2Fs00216-016-0119-3 |
| High mass resolution, spatial metabolite mapping enhances the current plant gene and pathway discovery toolbox | Y. Dong et al. | New Phytologist 2020, 228, 6, 1986-2002 | https://nph.onlinelibrary.wiley.com/doi/10.1111/nph.16809 |
Imaging – Pharmacology/Toxicology
| Title | Authors | Publication | Link |
|---|---|---|---|
| Quantitative Mass Spectrometry Imaging to Study Drug Distribution in the Intestine Following Oral Dosing | L. R. S. Huizing et al. | Analytical Chemistry 2021, 93, 4, 2144-2151 | https://pubs.acs.org/doi/10.1021/acs.analchem.0c03956 |
| An optimized method for the detection and spatial distribution of aminoglycoside and vancomycin antibiotics in tissue sections by mass spectrometry imaging | N. Wang et al. | Journal of Mass Spectrometry 2021, 56, 3, e4708 | https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.4708 |
| Distribution of perfluorooctane sulfonate in mice and its effect on liver lipidomic | X. Li et al. | Talanta 2021, 226, 122150 | https://www.sciencedirect.com/science/article/abs/pii/S0039914021000710 |
| An orthogonal methods assessment of topical drug concentrations in skin and the impact for risk assessment in the viable epidermis | B. D. Hollingshead et al. | Regulatory Toxicology and Pharmacology, 123, 2021, 104934 | https://www.sciencedirect.com/science/article/abs/pii/S027323002100074X |
| Multiorgan Crystal Deposition of an Amphoteric Drug in Rats Due to Lysosomal Accumulation and Conversion to a Poorly Soluble Hydrochloride Salt | B. Lenz et al. | Toxicological Sciences, 180(2), 2021, 383-394 | https://academic.oup.com/toxsci/article/180/2/383/6102740 |
| Study of the Distribution of Acetaminophen and Its Metabolites in Rats, from the Whole-Body to Isolated Organ Levels, by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging after On-Tissue Chemical Derivatization | M. Merdas et al. | Analytical Chemistry 2021, 93, 39, 13242-13250 | https://pubs.acs.org/doi/10.1021/acs.analchem.1c02487 |
| Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood–brain barrier | D. Luptáková et al. | Molecular Psychiatry 2021, 1-14 | https://www.nature.com/articles/s41380-021-01267-y |
| Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat | J. A. Werner et al. | Toxicology and Applied Pharmacology 2021, 423, 115578 | https://www.sciencedirect.com/science/article/pii/S0041008X2100185X |
| Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats | F. Romero-Palomo et al. | Toxicologic Pathology 2021, 49, 6, 1174-1192 | https://journals.sagepub.com/doi/10.1177/01926233211011615 |
| Partitioning and Spatial Distribution of Drugs in Ocular Surface Tissues | A. Balla et al. | Pharmaceutics 2021, 13, 5, 658 | https://www.mdpi.com/1999-4923/13/5/658 |
| Lesion Penetration and Activity Limit the Utility of Second-Line Injectable Agents in Pulmonary Tuberculosis | J. P. Ernest et al. | Antimicrobial Agents and Chemotherapy 2021, 65, 10, e00506-21 | https://journals.asm.org/doi/10.1128/AAC.00506-21 |
| Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis | K. Becker et al. | EBioMedicine 2021, 73, 103652 | https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00446-1/fulltext |
| Mass spectrometry imaging reveals lipid upregulation and bile acid changes indicating amitriptyline induced steatosis in a rat model | J. M. Kampa et al. | Toxicology Letters 2020, 325, 43-50 | https://www.sciencedirect.com/science/article/abs/pii/S0378427420300564 |
| Brain distribution of geissoschizine methyl ether in rats using mass spectrometry imaging analysis | T. Matsumoto et al. | Scientific Reports 2020, 10, 1, 7293 | https://www.nature.com/articles/s41598-020-63474-x |
| Drug Administration Routes Impact the Metabolism of a Synthetic Cannabinoid in the Zebrafish Larvae Model | Y. M. Park et al. | Molecules 2020, 25, 19, 4474 | https://www.mdpi.com/1420-3049/25/19/4474 |
Imaging – Protocols
| Title | Authors | Publication | Link |
|---|---|---|---|
| In Situ Localization of Plant Lipid Metabolites by Matrix-Assisted Laser Desorption/Ionization Mass SpectrometrySpectrometry Imaging (MALDI-MSI) | D. Sturtevant et al. | Methods in Molecular Biology 2021, Vol. 2295, 417-438 | https://link.springer.com/protocol/10.1007%2F978-1-0716-1362-7_24 |
| Multiplexed Imaging Mass Spectrometry of Histological Staining, N-Glycan and Extracellular Matrix from One Tissue Section: A Tool for Fibrosis Research | C. L. Clift et al. | Methods in Molecular Biology 2021, Vol. 2350, 313-329 | https://link.springer.com/protocol/10.1007%2F978-1-0716-1593-5_20 |
| Spatial visualization of comprehensive brain neurotransmitter systems and neuroactive substances by selective in situ chemical derivatization mass spectrometry imaging | R. Shariatgorji et al. | Nature Protocols 2021, 16, 7, 3298-3321 | https://www.nature.com/articles/s41596-021-00538-w |
| Investigation of Xenobiotics Metabolism In Salix alba Leaves via Mass Spectrometry Imaging. | C. Villette et al. | Journal of Visualized Experiments 2020, 160, e61011 | https://www.jove.com/de/t/61011/investigation-xenobiotics-metabolism-salix-alba-leaves-via-mass |
For Research Use Only. Not for use in clinical diagnostic procedures.