Advance your Biologics Discovery with Cutting-Edge Bruker Technology at PEGS Boston 2026!
Register today to explore Bruker’s unparalleled portfolio of analytical technologies for Biologics development. Our cutting-edge optofluidic and biophysical platforms unlock new possibilities in your discovery workflows. Capabilities range from single B cell and T cell screening to high-throughput epitope binning to kinetic measurements directly on cells.
Accelerate your research with the innovative tools trusted by leading scientists and pharmaceutical innovators around the globe. Find out more below.
Track: Antibodies for Cancer Therapy
From high-throughput screening to kinetics directly on cells: streamlining antibody discovery with biophysical insights
As antibody formats grow more complex, precise biophysical characterization becomes essential. We present a workflow combining high-throughput SPR for epitope binning and interaction screening, switchSENSE® for affinity vs. avidity and ternary complex detection, and single-cell Interaction Cytometry for real-time kinetics on living cells in native context. Together, these tools support informed antibody design and selection.
Rafael Levin
Application Scientist, Bruker Biosensors, Boston, MA, USARafael Levin ("Rafa") is working as Application Scientist at Bruker Biosensors, applying and supporting the molecular interaction technologies Surface Plasmon Resonance (SPR), switchSENSE®, and single-cell Interaction Cytometry (scIC). Rafa brings extensive expertise in the biophysical tool space, having studied diverse protein-protein interactions in human disease and immunology throughout his time in graduate school and industry.
Sven Malik
Business Development Manager, Bruker Biosensors, Hamburg, GermanySven studied Bioprocess Engineering at the Technical University of Dresden, Germany and graduated in 2012. During his diploma studies he investigated the interaction of cytomegalovirus protein pp65 against certain antibodies using Surface Plasmon Resonance. In 2012 he joined Sierra Sensors GmbH to start his role as application specialist. After 6 years he became senior application specialist as Bruker acquired Sierra Sensors GmbH. Currently he is the Business Development Manager for SPR within the Bruker Biosensors Team.
Track: Advancing Multispecific Antibodies and Combination Therapy to the Clinic
Function-First Single-Cell Discovery and Characterization of Bispecific T Cell Engagers
Traditional multispecifics discovery focuses on first identifying monoclonal antibody binders, while pushing functional characterization and engineering into later, more expensive screening.
As therapeutic modalities become more complex and engineering becomes another constraint, the Beacon® optofluidic platform enable researchers to characterize antibodies and bispecifics for function first and expand beyond bulk screening.
We will highlight a recent T cell engager screening case study against functional cytotoxicity and multiple cytokine secretion with single-cell granularity.
Vincent Pai
Director of Product Management, Bruker Cellular Analysis, Emeryville, CA, United States
Vincent Pai joined Bruker Cellular Analysis in 2016 and now leads new product development for antibody discovery applications on the Beacon® optofluidic system as part of the product management team. He has over 12 years of experience in cell biology, nanotechnology, and microfluidics, previously working in a translational microfluidics lab at Massachusetts General Hospital in Boston and earning his master's in Biomedical Sciences at UC San Diego.
Discover the scientific posters showcasing application examples of our technologies:
2BIND
Binding kinetics measured on cells – pain or gain?
BRUKER BIOSENSORS
Integrated biophysical analysis of Fc–FcR binding, affinity, and avidity in antibody therapeutics
BRUKER CELLULAR ANALYSIS
Function-first single-cell discovery and characterization of bispecific T cell engagers
ROUKENBIO
Target density matters - binding kinetics of antibody-based therapeutics are highly influenced by target expression levels
As you are certainly aware, special compliance regulations apply to public officials* and healthcare professionals** with regard to the event we are planning. If you accept our invitation, we will therefore assume that you will observe the compliance regulations that apply to you and that you have the necessary employer approval.
*Government Official means according the Bruker policies any of the following: any officer, employee or representative of a government (national, regional or local) entity, or any public agency, public authority, department or instrumentality thereof, regardless of their rank or title (e.g. a regulatory official or government inspector); any person working for or advising a government-owned or government-controlled enterprise (e.g. a professor at a government-owned university, or a purchaser at a government-owned hospital); any person working for or advising a national or international non-governmental organization (e.g. an employee of the Red Cross or The World Bank); any person performing a public function or providing a public service, even if that person works for a non-governmental institution (e.g. private security personnel working in public functions); any person hired to review or accept bids for a government agency; any person with the responsibility to allocate or expend government funds; any person in a public law function, civil servant, judge or military personnel; any person acting for a political party, including party officials, candidates or individuals holding a position in a political party office; members of royal families; or immediate family members of any of the persons listed above. An immediate family member is a grandparent, parent, spouse, significant other, child, or sibling.
**A Healthcare Professional (HCP) is in accordance with the Bruker policies any physician, dentist, nurse, pharmacist or other individual who may prescribe, administer, purchase, dispense, recommend, or supply medical products or treatments or pharmaceutical products. In many cases, Bruker interacts with HCPs who work for state-owned hospitals (e.g. as medical scientists). These individuals will be classified as both HCPs and Government Officials.
For Research Use Only. Not for use in clinical diagnostic procedures.